Clinical trials
Rectal Cancer Patients clinical trials
Below are recruiting rectal cancer patients clinical trials, each written for real people, not researchers. We’re tracking 360 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04098471Recruiting
Comparing two rectal cancer surgeries for T2 tumors
This trial compares two different surgery approaches for early-stage rectal cancer (T2N0M0) that is close to the anus. It tests whether a less invasive local removal followed by radiation works as well as more extensive surgery (total mesorectal excision).
Nanjing, JiangsuAges 18–75 - NCT04075305Recruiting
Study measuring radiation treatment outcomes with an MR-Linac
This study follows what happens when radiation treatment is guided using an MR-Linac (a special machine that combines MRI imaging with radiation). It may help improve how radiation therapy is planned and assessed, especially for people who can safely have MRI scans.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT03874559Recruiting
Testing exosomes during treatment for rectal cancer
This trial studies “exosomes” (tiny cell signals being researched as a possible way to affect cancer treatment) in people with rectal cancer. You would receive standard chemotherapy plus radiation before planned surgery, and the trial looks at outcomes related to that treatment.
Kansas City, KansasAges 18 years+ - NCT03853733Recruiting
Shorter radiation plan for non-surgery rectal cancer
This trial looks at a shorter radiation schedule for people with advanced rectal (or nearby sigmoid) cancer who cannot have surgery. The goal is to control the cancer while keeping treatment simpler, especially for those who cannot safely undergo an operation.
Terrassa, CataloniaAges 18 years+ - NCT03594630RecruitingEarly Phase 1
Watchful waiting then chemotherapy before surgery for rectal cancer
This trial studies whether a period of active surveillance (watching closely) and chemotherapy before surgery can improve outcomes for people with stage II–III rectal cancer. You would also receive standard chemo-radiation if you qualify, then proceed to surgery.
Houston, TexasAges 18 years+ - NCT03516708RecruitingPhase 1/Phase 2
Epacadostat with pre-op radiation for locally advanced rectal cancer
This trial studies whether adding epacadostat (a cancer drug) to standard pre-operative chemoradiation can improve outcomes for people with locally advanced rectal cancer. It’s designed to see if the added treatment is safe and potentially more effective before surgery.
Orange, CaliforniaAges 18 years+ - NCT03190941RecruitingPhase 1/Phase 2
T-cell therapy for HLA-A11:01 and KRAS G12V tumors
This trial tests a custom immune-cell treatment made from your blood that targets the KRAS G12V change in certain cancers. It is for people with advanced cancer who have already tried standard treatments, and it may help your immune system recognize and attack tumor cells.
Bethesda, MarylandAges 18–72 - NCT03051464RecruitingPhase 2/Phase 3
Testing two ways to boost radiation to prevent rectal surgery
This study looks at whether two different added “boosts” of radiation can work as well for rectal cancer patients, aiming to avoid or reduce the need for rectal cancer surgery. You would receive a specific combination of radiation (including brachytherapy) and chemotherapy, and your tumor’s location and size will determine if you can take part.
Dallas, TexasAges 18–80 - NCT02107105Recruiting
Study how surgery affects life quality in rectal cancer
This trial studies how surgical treatment for rectal cancer affects patients’ quality of life and other day-to-day impacts. It may help doctors understand what to expect after surgery and how to better support patients.
Houston, TexasAges 18 years+ - NCT03280511RecruitingPhase 2
After surgery chemo sprayed into the abdomen for high-risk colon cancer
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
OdenseAges 18 years+ - NCT05972655RecruitingPhase 2
Testing shorter rectal radiation with chemotherapy plus immunotherapy
This Phase 2 study tests whether a shorter course of radiation, combined with chemotherapy (CAPOX) and an immunotherapy drug (tislelizumab), can control middle and low rectal cancer. It may also help people who strongly want to keep their anus, if the cancer and overall health fit the study rules.
Hanzhou, ZhejiangAges 18–75 - NCT07281157RecruitingPhase 2
Liposomal irinotecan, capecitabine and enlonstobart with short radiation for rectal cancer
This trial tests a combination of short-course radiation, two chemotherapy drugs (liposomal irinotecan and capecitabine), and an immunotherapy drug (Enlonstobart) for people with locally advanced rectal cancer. The goal is to see if this approach can shrink the tumor before surgery.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07098182Recruiting
Preserving blood supply during colon or rectal surgery
This trial tests a technique during colon or rectal surgery to preserve a specific blood vessel (the left colic artery) that helps keep the remaining colon healthy. It is for people with left colon, rectal, or ovarian cancer who are scheduled for surgery.
Montpellier, HeraultAges 18 years+ - NCT06904365Recruiting
Ovarian-sparing radiation for young women
This study tests a way to give radiation therapy that avoids the ovaries as much as possible, to help preserve fertility and hormone function in young women.
St Louis, MissouriAges 18–50 - NCT05732389RecruitingPhase 2
Immunotherapy for early rectal cancer with dMMR or MSI
This trial studies whether immunotherapy (nivolumab plus ipilimumab) can help people with early-stage rectal cancer that has dMMR or MSI changes. It’s meant for patients who have not yet had chemotherapy, radiation, or immunotherapy for colorectal cancer.
AalborgAges 18 years+ - NCT06563388RecruitingPhase 3
SABR for limited metastatic cancer (ID-COMET trial)
This study tests a precise radiation technique called SABR to treat cancer that has spread to a few spots. It aims to see if this approach can help control the cancer better than usual treatment, especially for lung, prostate, colorectal, or other solid tumors with limited spread.
Buffalo, New YorkAges 1 year+ - NCT06380101Recruiting
Special diet with standard therapy for rectal cancer
This trial tests a special medical food that limits certain amino acids (building blocks of protein) during standard treatment for rectal cancer. The goal is to see if this diet helps the treatment work better while reducing side effects.
Tampa, FloridaAges 18–100 - NCT04525989Recruiting
Short-course proton vs photon radiation before rectal surgery
This study compares two types of pre-surgery radiation—protons versus standard photons—in people with high-risk rectal cancer. The goal is to shrink and control the tumor while safely getting you ready for surgery, and to see which approach works better.
Stockholm, SolnaAges 18 years+ - NCT07786493Recruiting
3D-printed internal radiation for rectal cancer
This study tests a new way to deliver internal radiation therapy (brachytherapy) to rectal cancer using a 3D-printed guide. It may help people who cannot have or do not want surgery, with the goal of preserving the rectum.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06576986Recruiting
Can a supplement prevent mouth sores during chemo?
This trial tests whether a special supplement (synbiotic) can prevent mouth sores caused by chemotherapy in people with colorectal cancer. It's for those starting treatment who live in or near Belo Horizonte, Brazil.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07469709Recruiting
Cancer risk study using genetics and monitoring
This study looks at genetic and other factors in people with certain cancers to better understand personal cancer risks and improve monitoring. It may help find ways to detect changes earlier.
Candiolo, TurinAges 18 years+ - NCT07145255RecruitingPhase 1/Phase 2
Study of MBRC-201 for advanced solid tumors
This trial tests a new drug, MBRC-201, for people with advanced solid tumors that have not responded to standard treatments. The goal is to find the best dose and see if it helps shrink tumors or slow their growth.
San Francisco, CaliforniaAges 18 years+ - NCT03064646Recruiting
Preserving tissue in near-complete rectal cancer response
This trial studies whether it’s safe to preserve the rectum (instead of removing it right away) for people with locally advanced rectal cancer who respond very well after pre-treatment radiation and/or chemotherapy. It may help some patients avoid major surgery, but eligibility depends on response seen on exam, scope, and MRI, and on having no spread to distant organs.
Elche, AlicanteAges 18 years+ - NCT03466424Recruiting
Short radiation then chemotherapy for locally advanced rectal cancer
This trial tests a short course of radiation given before chemotherapy for people with locally advanced rectal cancer (cancer that has grown into nearby tissue and/or nearby lymph nodes but can still be removed). It may help shrink the tumor and make treatment more effective while assessing how well this approach works.
Fuzhou, FujianAges 18–70
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Common questions
- Are there clinical trials for rectal cancer patients?
- Yes. Clin2 currently lists 360 recruiting rectal cancer patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.