Clinical trials
Resistance clinical trials
Below are recruiting resistance clinical trials, each written for real people, not researchers. We’re tracking 1,210 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06717243Recruiting
Study on gene markers in lung cancer for treatment resistance
This study looks at genetic markers in two types of lung cancer (small cell and large cell neuroendocrine) to understand why some tumors stop responding to a standard treatment that combines chemotherapy with immunotherapy. If you have one of these cancers and are about to start this treatment, you may be able to join.
New York, New YorkAges 18–85 - NCT06719791RecruitingEarly Phase 1
Sirolimus for hard-to-treat focal epilepsy
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
BeijingAges 18–60 - NCT06723886Recruiting
Can olive pomace oil help control blood sugar?
This study tests whether olive pomace oil, a type of olive oil, can lower blood sugar in people with prediabetes or diabetes. It may be an option if you have high blood sugar and are not taking other medications or supplements.
Madrid, MadridAges 20–70 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06729203Recruiting
Ultrasound for belly fat and insulin resistance in women
This trial tests if ultrasound cavitation—a non-invasive treatment that uses sound waves to break down fat—can help lower insulin resistance in women with central obesity (fat around the belly). It's a possible option if you have insulin resistance and are not taking diabetes medication.
Giza, Giza GovernorateAges 25–40 - NCT06732141Recruiting
Phone program for asthma anxiety and medication adherence
This study tests a telephone-based program to help people with asthma who feel anxious about using their daily inhaled steroid medication. It aims to reduce anxiety and improve how well you stick to your treatment plan.
HarbinAges 18–80 - NCT06733987Recruiting
Pembrolizumab and immune aging in relapsed Hodgkin lymphoma
This study looks at how a type of immune cell aging (called 'immunological senescence') might affect how well the drug pembrolizumab works in people whose Hodgkin lymphoma has come back or not responded to treatment.
BolognaAges 18 years+ - NCT06735651Recruiting
Wild blueberries for gut, brain, and heart health in prediabetes
This study looks at whether eating wild blueberries can improve your gut health, brain function, and heart health if you have prediabetes. It may help lower your blood sugar and reduce your risk for diabetes and heart disease.
Atlanta, GeorgiaAges 20–65 - NCT06738771Recruiting
Antibiotic treatment for tough Pseudomonas infections
This study tests a specific antibiotic plan for adults with a hard-to-treat Pseudomonas infection that needs IV medicine. It aims to find the best way to treat these serious infections.
AmiensAges 18 years+ - NCT06740916RecruitingPhase 3
Aspirin once vs. twice daily for high-risk MPN patients
This trial tests whether taking aspirin once or twice daily better prevents blood clots in high-risk patients with myeloproliferative neoplasms (MPNs) who don't respond fully to aspirin. It's for people whose blood tests show aspirin resistance.
Bangkok Noi, BangkokAges 18 years+ - NCT06748209RecruitingPhase 4
Mobile TMS for treatment-resistant depression
This trial tests if delivering transcranial magnetic stimulation (TMS) through a mobile unit can help people with depression that hasn't improved with other treatments.
Charleston, South CarolinaAges 22–80 - NCT06757712Recruiting
Resistance training for quality of life in women with hypothyroidism
This trial tests if a special resistance-training schedule can improve quality of life in women with well-controlled hypothyroidism who are also overweight. You will follow a periodized (changing intensity) exercise plan and see how it affects your daily energy and well-being.
SuezAges 35–45 - NCT06768827Recruiting
Obesity mechanisms study for teens
This study looks at how bodies process food to understand obesity in teenagers. It may help find new ways to prevent or treat obesity.
New Haven, ConnecticutAges 15–22 - NCT06773949Recruiting
Exercise before rTMS for hard-to-treat depression
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
Ottawa, OntarioAges 18–75 - NCT06775678RecruitingPhase 2
Spatial fragmentation plus low-dose radiation for resistant lung cancer
This study tests whether combining a special type of radiation (spatial fragmentation) with low-dose radiation can help people whose lung cancer stopped responding to immunotherapy and chemotherapy. If you are eligible, you may receive a new treatment approach to try to shrink the tumors.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06779864Recruiting
Hepatitis B virus genetics and drug resistance study
This study looks at how hepatitis B virus changes in your body, including mutations and drug resistance, using your blood or liver tissue samples. Understanding these changes could help improve treatment for hepatitis B.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06782867Recruiting
Brain implant study for treatment-resistant OCD
This trial tests whether a brain implant, called responsive neurostimulation (RNS), can help people with obsessive-compulsive disorder (OCD) that has not improved with standard treatments. It is designed for adults who have tried multiple medications and therapy without success.
BeijingAges 18–65 - NCT06784193RecruitingPhase 1
Study of OP-3136 for advanced solid tumors
This trial tests a new drug, OP-3136, alone or with other drugs, for people with advanced breast cancer, prostate cancer, or lung cancer that has stopped responding to other treatments. It aims to see if OP-3136 is safe and effective.
Sarasota, FloridaAges 18 years+ - NCT06784388RecruitingEarly Phase 1
Deep brain stimulation for tough-to-treat depression
This early trial tests a personalized deep brain stimulation (DBS) approach for people with major depression that hasn't improved with at least two different antidepressants. DBS uses small electrodes placed in the brain to adjust mood-related circuits.
Hangzhou, ZhejiangAges 18–70 - NCT06785636RecruitingPhase 1/Phase 2
New drug combination for advanced prostate cancer
This study tests a new drug (pocenbrodib) alone or combined with another hormone therapy (darolutamide) for men with advanced prostate cancer that has spread. It is for those who have already tried Pluvicto and one other hormone therapy, but not yet chemotherapy.
Fountain Valley, CaliforniaAges 18 years+ - NCT06791941Recruiting
Studying therapy resistance in recurrent head and neck cancer
This study looks at why some head and neck cancers come back after treatment. It will test tumor tissue from people having surgery to see if certain proteins (mutant p53 and YAP) are linked to treatment resistance. Your participation could help researchers understand how to better treat these cancers in the future.
Roma, RomeAges 18 years+ - NCT06792799RecruitingEarly Phase 1
CAR-NK cells for B-cell autoimmune diseases
This early phase trial tests a new treatment made from immune cells (CAR-NK cells) that target and destroy overactive B cells. It may help people with lupus, certain kidney diseases, or nephrotic syndrome that hasn't responded to standard therapies.
Hangzhou, ZhejiangAges 3 years+ - NCT06794606Recruiting
Study for drug-resistant focal epilepsy
This trial looks at ways to diagnose and treat focal epilepsy that isn't controlled by medications. It includes patients with or without a visible brain lesion on imaging.
MilanAges 18 years+ - NCT06799481Recruiting
Home-based exercise to help brain tumor survivors with thinking and memory
This study tests whether a virtual home-based exercise program can improve thinking and memory problems caused by brain tumor treatment in teens and young adults. It also looks at how exercise affects gut health.
Atlanta, GeorgiaAges 15–39
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Common questions
- Are there clinical trials for resistance?
- Yes. Clin2 currently lists 1,210 recruiting resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.