Clinical trials
Resistance clinical trials
Below are recruiting resistance clinical trials, each written for real people, not researchers. We’re tracking 1,200 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07384897Recruiting
Immune cells in lung cancer and chronic lung disease
This study looks at how immune cells work in lung cancer and chronic lung diseases. It aims to find better ways to treat these conditions by studying immune cells from blood, bone marrow, or lung samples.
BrusselsAges Up to 80 years - NCT01994057Recruiting
Looking back at EGFR-targeted pills for lung cancer
This study looks back at how people with non-small cell lung cancer (NSCLC) were treated with EGFR-targeted medicines (gefitinib, erlotinib, and osimertinib). It may help doctors understand which patients benefit most and what side effects to expect.
Guangzhou, GuangdongAges 18–85 - NCT01580982Recruiting
Analyze tumor genetic changes to understand lung cancer resistance
This study looks at lung cancer tumor tissue to find genetic “on/off” changes and why treatments may stop working. It may help your care team choose better next tests or treatments based on what the tumor is doing.
Aurora, ColoradoAges 18–85 - NCT00001987Recruiting
Understanding genetics of insulin resistance and diabetes
This research study looks at the genes and immune system factors that cause severe insulin resistance—a condition where the body doesn't respond well to insulin. Researchers want to understand why some people develop this problem and study family members and healthy volunteers to learn more.
Bethesda, MarylandAges 6 months–120 years - NCT01224886Recruiting
Study of age-related insulin resistance and exercise
This study looks at how age affects the way your body uses insulin (a hormone that helps move sugar into cells), and how lifestyle or exercise may change that. It may help you understand insulin resistance and whether changes in activity could improve blood sugar control.
BernAges 60–80 - NCT01746836RecruitingPhase 2
Ponatinib for CML that didn’t respond to prior pills
This trial studies ponatinib as a second treatment for chronic myeloid leukemia (CML) when it didn’t fully respond or couldn’t be tolerated with at least one prior CML pill. It aims to see whether ponatinib can better control leukemia levels after earlier treatments.
Houston, TexasAges 18 years+ - NCT01210274Recruiting
Study how people resist azacitidine in blood cancers
This study looks at why some people with higher-risk blood cancers (MDS/AML-MD) do not respond as well to azacitidine. The goal is to learn the causes of resistance so future treatments may work better.
AntibesAges 18 years+ - NCT01143480Recruiting
Testing how the body responds to endotoxin
This study checks how your immune system (your body’s defense system) reacts to a controlled substance that triggers inflammation. It may help researchers understand why some people have stronger or weaker inflammatory responses.
Research Triangle Park, North CarolinaAges 18–100 - NCT02208141Recruiting
Child body growth study with planned surgery
This study follows children’s body growth and fat (adipose) tissue as part of a planned surgical procedure. It aims to improve understanding of how fat tissue develops in childhood and what factors may affect health later.
Leipzig, SaxonyAges Any age - NCT02122562RecruitingPhase 2
Ketamine treatment for depression that hasn’t responded to care
This Phase 2 study tests ketamine for people with major depression that hasn’t improved after at least one antidepressant. It aims to see whether ketamine can reduce depression symptoms during a current depressive episode.
Iowa City, IowaAges 18–55 - NCT02844049Recruiting
Quality-of-life study for treatment-resistant OCD with DBS
This study looks at whether deep brain stimulation (DBS) helps people with long-term, treatment-resistant obsessive-compulsive disorder (OCD), and how it affects quality of life. It involves careful screening because it’s meant for OCD that has not responded to several medication and therapy attempts.
CréteilAges 18–69 - NCT02861781Recruiting
Collecting body tissue samples during bariatric surgery
This study collects small tissue samples during planned weight-loss surgery to better understand metabolism and how insulin works in people with and without type 2 diabetes. You may help researchers by allowing their team to take these samples while you are already having surgery.
MontpellierAges 18–65 - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT02646475RecruitingPhase 1
Study angiotensin medicine to improve metabolism in obesity
This Phase 1 study tests how a medication that affects the body’s angiotensin system (angiotensin-(1-7)) changes metabolism in adults with obesity, insulin resistance, and high blood pressure. It may help researchers understand whether this approach can improve blood sugar/insulin function and related body changes.
Nashville, TennesseeAges 18–60 - NCT03320304Recruiting
VNS for long-term depression that hasn’t improved with treatment
This trial studies how well and how efficiently VNS therapy works for people with long-lasting or repeated major depression that hasn’t responded to enough antidepressant treatments. It may help patients who are already receiving depression treatment but are still struggling.
ViennaAges 18 years+ - NCT02947503RecruitingPhase 3
Metformin for gestational diabetes in pregnancy outcomes
This study tests whether taking metformin during pregnancy improves outcomes for people with gestational diabetes. It may help with pregnancy health and baby outcomes compared with the study’s other diabetes care plan.
GroningenAges 18–45 - NCT07599072Recruiting
Blood Sugar Monitoring Study for Prediabetes
This study tracks how blood sugar levels change in people with prediabetes (higher-than-normal blood sugar but not yet diabetes). Researchers will use a small sensor to monitor your blood sugar and help understand what affects it, which could help prevent or delay type 2 diabetes.
KyivAges 18 years+ - NCT01933620Enrolling by invitation
NIH study of the microbiome using stored body samples
This study looks at the community of microbes in the body (your “microbiome”) using samples like stool, urine, and possibly tissue. It may help researchers understand how these microbes relate to health in hospital patients.
Bethesda, MarylandAges 2–120 - NCT07399327Recruiting
SEEG thermocoagulation for hard-to-treat epilepsy
This study is looking at how well a procedure called SEEG thermocoagulation (a way to stop seizures by heating a small area of brain tissue) works for people with epilepsy that doesn't improve with medication. By joining, you will help doctors understand why this treatment works for some people and not others.
MarseilleAges 12 years+ - NCT07400367Recruiting
Probiotics and lifestyle changes for fatty liver disease
This trial tests whether taking probiotics plus making lifestyle changes can improve fatty liver and metabolic health. You may qualify if you have liver fat and at least one sign of metabolic problems like high blood sugar or high blood pressure.
New Taipei CityAges 18–80 - NCT07403786Recruiting
Testing a new way to find blockages in the urethra
This study is testing a new ultrasound measurement called the Urethral Resistive Index (URI) to see if it can accurately diagnose urethral stricture (a narrowing in the tube that carries urine out of the body). The goal is to find a less invasive way to diagnose blockages without needing a scope.
Ankara, UniversitelerAges 18–80 - NCT07408063RecruitingPhase 2
Study of new drug for advanced head and neck cancer
This trial tests a new drug (GSK5764227) for head and neck cancer that has spread or come back. It looks at your tumor's biomarkers to understand why some people respond to treatment. You may need to have had certain prior treatments depending on which group you join.
Toronto, OntarioAges 18 years+ - NCT07415720Recruiting
Artichoke and Mediterranean diet to prevent type 2 diabetes
This study tests whether a special extract from artichoke by-products, combined with a Mediterranean diet, can help prevent type 2 diabetes in people who are at risk. It aims to improve how your body handles sugar and insulin.
Pamplona, NavarreAges 18–75 - NCT07424352Recruiting
Rotational exercise for knee osteoarthritis
This study tests a special rotational exercise device to see if it can improve knee function and reduce pain in people with knee osteoarthritis. It involves supervised sessions at the university and may help you move better without surgery.
Aurora, ColoradoAges 40–70
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Common questions
- Are there clinical trials for resistance?
- Yes. Clin2 currently lists 1,200 recruiting resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.