Clinical trials
Severe Aortic Stenosis clinical trials
Below are recruiting severe aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 141 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07335900Recruiting
Studying heart healing after TAVI with FAPI-PET scan
This study uses a special type of PET scan (FAPI-PET) to see how the heart heals after a less invasive valve replacement procedure called TAVI. It aims to help doctors better understand the changes in heart tissue after treatment for aortic stenosis.
ShanghaiAges 18 years+ - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT07193888Recruiting
Navitor valve study for aortic stenosis
This study is testing the Navitor valve, a device to replace a narrowed aortic heart valve without open-heart surgery. It will track how well the valve works in people who are already good candidates for this procedure.
FukuokaAges 18–100 - NCT07145463Recruiting
New delivery system for severe aortic stenosis treatment
This trial tests a new delivery system (VitaFlow Liberty Flex) for placing a replacement aortic valve in people with severe aortic stenosis. It is designed for patients whose heart anatomy (a steep angle between the heart and aorta) makes the procedure more challenging.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07144189Recruiting
AI helps diagnose low-gradient aortic stenosis
This trial is testing whether an artificial intelligence (AI) program can better identify low-gradient aortic stenosis, a type of heart valve narrowing, by looking at your echocardiogram (heart ultrasound). It aims to help doctors diagnose this condition more accurately without any extra procedures.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07097740Recruiting
Study of a new polymer heart valve for mitral or aortic replacement
This study tests a new type of prosthetic heart valve made from a special polymer material. It is for adults who need surgical replacement of either the mitral or aortic valve.
Shanghai, Shanghai MunicipalityAges 50 years+ - NCT06898086Enrolling by invitation
TAVI with or without heart artery check for severe aortic stenosis
This trial compares two approaches for replacing a tight aortic heart valve (TAVI) through a leg artery: doing it with or without a routine check of your heart's arteries (coronary angiogram). If you have severe aortic stenosis and are scheduled for TAVI, this study helps find out whether skipping the artery check is safe and effective.
GrazAges 18 years+ - NCT06859255Recruiting
Comparing heart valves for small aortic openings
This trial compares different types of heart valves (surgical and less-invasive) used in people with a small heart valve opening. It aims to see which valves work best, and will follow up with patients who already had the procedure.
Bari, ApuliaAges Any age - NCT06816485Recruiting
New balloon safety in TAVI for severe aortic stenosis
This trial studies a new balloon used during a TAVI procedure to replace your aortic valve without open-heart surgery. It aims to see if the balloon is safe and works well for people with severe aortic stenosis.
BarcelonaAges 18 years+ - NCT06679517Enrolling by invitation
Long-term follow-up for severe aortic stenosis patients considered for TAVI
This study follows patients with severe aortic stenosis (a heart valve condition) who are being evaluated for a keyhole procedure called TAVI. It aims to understand their long-term outcomes after the standard evaluation process.
FerraraAges 18 years+ - NCT06638268Recruiting
TAVI for severe aortic stenosis in cardiogenic shock
This study tests whether a procedure called TAVI (a valve replacement done through a tube in the leg) can help people with severe aortic stenosis who are in cardiogenic shock, a dangerous condition where the heart can't pump enough blood. The goal is to see if urgent valve replacement improves survival.
Copenhagen OAges Any age - NCT06597188Enrolling by invitation
TAVR vs. Surgery for severe bicuspid aortic valve stenosis
This trial compares a less invasive valve replacement (TAVR) with traditional open-heart surgery for people with a specific type of severe aortic valve narrowing (bicuspid valve). It aims to see which approach works better for those at intermediate or low surgical risk.
Chengdu, SichuanAges 18–75 - NCT06596460Recruiting
Imaging study after TAVI valve replacement
This study collects extra imaging data from 40 people who are already scheduled for a routine TAVI procedure to replace a narrowed aortic heart valve. The goal is to better understand the valve's structure and function using scans.
London, EnglandAges 18 years+ - NCT06589063Recruiting
TAVR for severe low flow, low gradient aortic stenosis
This study tests whether TAVR (a minimally invasive valve replacement) helps people with a specific type of severe aortic stenosis where the heart doesn't pump as strongly. It aims to see if the procedure improves symptoms and outcomes.
SalernoAges 18 years+ - NCT06171737Enrolling by invitation
Shared decision-making for severe aortic stenosis
This study tests a way to help people with severe aortic stenosis make informed choices about treatment. It may help you talk with your heart team about options like valve replacement.
San Francisco, CaliforniaAges 65–85 - NCT06168370Recruiting
Personalized blood thinners after TAVI vs. standard care
This trial tests whether a personalized plan for blood thinners after TAVI can reduce the risk of stroke or bleeding better than the current standard of one daily blood thinner. If you've had a successful TAVI and don't need specific other blood thinners, you might be able to join.
NieuwegeinAges 18–110 - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT04889872Recruiting
Watchful waiting or TAVR for moderate aortic valve narrowing
This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
Huntsville, AlabamaAges 65 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT04204915Recruiting
Early valve replacement for severe but symptom-free aortic narrowing
This study looks at whether replacing a narrowed heart valve early helps people who have severe aortic stenosis but no symptoms. You would be randomly assigned to early valve replacement or careful waiting with regular check-ups.
Garran, Australian Capital TerritoryAges 18 years+ - NCT04968509RecruitingPhase 3
PCSK9 shots for calcified aortic valve narrowing
This study tests whether adding PCSK9 inhibitor injections (to statin treatment) can slow or improve calcific aortic valve stenosis, a condition where the heart’s aortic valve becomes stiff and narrowed. It’s aimed at adults with mild-to-moderate disease or certain people with severe disease but no symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+
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Common questions
- Are there clinical trials for severe aortic stenosis?
- Yes. Clin2 currently lists 141 recruiting severe aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.