Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 270 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07466589Recruiting
Electric stimulation for dizziness after concussion
This trial tests if a portable electric stimulation device can help improve balance and reduce dizziness in people recovering from a concussion. If you have had ongoing imbalance for at least 4-6 weeks, this study may help you feel steadier.
Ann Arbor, MichiganAges 18–55 - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07624825Recruiting
Emotional Awareness Therapy After Brain Injury
This study tests whether a therapy focused on recognizing and understanding emotions can help people recover better after a moderate or severe traumatic brain injury (TBI). You'll participate if you're at least 6 months past your injury and struggle to identify or describe your feelings.
Edison, New JerseyAges 18 years+ - NCT07065916Enrolling by invitation
Arm More + Camp: Helping kids with arm weakness
This trial tests a program called 'Arm More + Camp' to help kids and teens with arm weakness due to cerebral palsy or a brain injury improve their movement. It’s a group camp-style study that fits into the school year.
Calgary, AlbertaAges 5–17 - NCT06973018Enrolling by invitation
Online cognitive rehab for mild memory problems
This trial tests an online program to help people with mild to moderate cognitive problems after a brain injury or nervous system disease improve their thinking skills. It is for Swedish speakers with internet access.
Stockholm, Stockholm CountyAges 18 years+ - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT04043442Enrolling by invitationPhase 2
Brain stimulation study for alcohol use with mild brain injury
This trial tests a type of brain stimulation to help with day-to-day functioning in people who have alcohol use disorder and a history of mild traumatic brain injury. It also uses brain and symptom testing to see who may benefit most and why.
Hines, IllinoisAges 22–65 - NCT05213169RecruitingPhase 2/Phase 3
Apomorphine for severe unresponsive brain injuries
This trial tests whether apomorphine can improve care or outcomes for people in an unresponsive wakefulness or minimally conscious state after a brain injury. It is designed for patients who are medically stable and not currently on certain brain- or heart- affecting medicines.
Liège, LiegeAges 18–80 - NCT06906432Recruiting
Brain-Heart Injury After Brain Bleed Study
This study looks at how a brain bleed can affect the heart. Researchers hope to understand the link between brain and heart injury to help improve care for people who have had a brain bleed.
Beijing, Beijing MunicipalityAges 18–80 - NCT07106060Recruiting
Brain imaging of motor imagery effects in spinal cord injury
This study uses a special camera to see how imagining movement (motor imagery) affects brain activity in people with spinal cord injury. It aims to help understand how the brain recovers after injury.
Shenyang, LiaoningAges 18–75 - NCT07225582Recruiting
Best sensory feedback for hand function after spinal injury
This study is for people who have already received the ReHAB system in a previous trial. It aims to find the best ways to use sensory feedback from the device to help with hand and arm function after tetraplegia.
Cleveland, OhioAges 22–65 - NCT07357428Recruiting
Brain-computer implant study for severe paralysis or speech loss
This study tests a brain-computer implant that might help people with severe paralysis or speech loss control a computer with their thoughts. It is for people who have trouble moving and speaking due to a progressive disease or injury.
Sacramento, CaliforniaAges 22–75 - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Stanford, CaliforniaAges 18–80 - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT01894802Recruiting
Brain recording and stimulation to help control a computer
This study tests a brain-machine interface that records brain activity and uses stimulation to help people with severe hand/arm movement loss communicate or control tasks using a computer. It may help restore some control and reduce dependence on hands that cannot be used normally.
Chicago, IllinoisAges 22–70 - NCT06867809Recruiting
Spinal and brain stimulation for arm movement after neck injury
This study tests whether using a combination of spinal and brain stimulation can help improve arm and hand movement in people who have had a cervical spinal cord injury (neck area) at least one year ago. It is for those with some remaining movement but not full strength.
New York, New YorkAges 18 years+ - NCT05805683Recruiting
Calcitonin for nerve pain after spinal cord injury
This study tests whether calcitonin can prevent or lessen nerve pain after a spinal cord injury. It may help reduce how often neuropathic (nerve-type) pain happens and how severe it becomes.
Tanta, Gharbia GovernorateAges 18 years+ - NCT07603752Recruiting
Brain implant to restore arm movement in spinal cord injury
This trial tests a wireless implant placed on the brain's surface to help people with cervical (neck-level) spinal cord injuries regain some arm and hand movement. The device reads brain signals and sends them to muscles, potentially bypassing the damaged spinal cord.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06429735Recruiting
Robot-implanted brain-computer interface for severe paralysis
This trial tests a brain-computer interface (a device that lets you control a computer with your thoughts) that is implanted by a robot. It is for people with severe paralysis who may benefit from a new way to communicate or control devices.
Phoenix, ArizonaAges 22–75 - NCT06406855Recruiting
Brain-controlled spinal stimulation walking therapy for spinal cord injury
This trial tests a therapy that uses a brain-controlled device to stimulate your spinal cord while you practice walking. It aims to help people with incomplete spinal cord injury improve their walking ability.
Miami, FloridaAges 18–70 - NCT07784088Recruiting
Wireless brain implant for tetraplegia
This trial tests a new implantable brain-computer interface designed to help people with tetraplegia (paralysis of arms and legs) control devices using their thoughts. It may help improve independence and quality of life.
BeijingAges 18–65 - NCT04212780Recruiting
Testing a smarter DBS system for severe essential tremor
This trial tests an upgraded deep brain stimulation (DBS) system that can “sense” tremor and adjust treatment in a loop. It’s designed for people with severe essential tremor whose tremor is still disabling despite standard DBS and medication.
Gainesville, FloridaAges 21–99 - NCT06606119Recruiting
Brain, bone marrow, and gut study after major injury
This study is looking at how the brain, bone marrow, and gut interact after a severe injury. It may help doctors understand how to better treat trauma patients.
Gainesville, FloridaAges 18–100 - NCT06104735Recruiting
Hand training with brain and spinal cord stimulation after spinal cord injury
This study tests whether combining hand exercises with stimulation of the brain and spinal cord can improve hand function after a spinal cord injury. You would attend about 53 study visits at the Bronx VA Medical Center.
The Bronx, New YorkAges 18–85
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 270 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.