Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 276 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07025317Recruiting
Study on concussions and brain training in older adults
This study looks at how repeated concussions affect the brain as we age. It tests a computer-based brain training program and uses MRI scans to see if training can help improve thinking and memory.
Victoria, British ColumbiaAges 60 years+ - NCT06036147Recruiting
Concussion Recovery Program for Teens
This study tests a remote program to help teens ages 11 to 18 recover from a concussion that happened 1 to 12 months ago. You'll learn ways to manage symptoms like headaches, tiredness, or trouble focusing, all from home.
Dallas, TexasAges 11–18 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT07670195RecruitingPhase 2
BCAAs for concussion recovery in young people
This study tests if a supplement called BCAAs (branched-chain amino acids) can help young people recover from a concussion. It aims to see if BCAAs improve symptoms compared to a placebo.
Havertown, PennsylvaniaAges 11–23 - NCT07739264Recruiting
Robotic hand training for arm weakness
This study tests a robotic hand training system called ZEPU-SG1PLUS to help improve arm and hand function in people with various conditions like stroke or injury. It aims to see if this device can help you move better and do daily activities more easily.
DhakaAges 18–60 - NCT07404761Recruiting
Moving your arm after stroke or TBI
This study tests a device that uses mild electrical pulses and augmented reality (a computer overlay on real life) to help people who have arm or hand weakness after a recent stroke or brain injury regain movement.
HaifaAges 18 years+ - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT06733025Recruiting
Comparing surgery and Botox for arm spasticity
This trial compares two treatments—Botox injections or surgery—for arm and hand spasticity after a stroke, brain injury, or spinal cord injury. It may help you decide which option works best for you.
MölndalAges 18 years+ - NCT05725993Recruiting
Study of tiny blood-vessel brain injury after head trauma
This study follows people with a moderate, non-penetrating traumatic brain injury (TBI) to see how small blood-vessel damage changes over time. It uses brain scans to learn what happens after a serious accident, which may help improve future care.
Philadelphia, PennsylvaniaAges 18–65 - NCT07749612Recruiting
Robotic arm trainer for stroke and brain injury recovery
This trial tests a robotic device that helps people move their arms and hands during rehabilitation after a stroke, brain injury, or spinal cord injury. The goal is to improve arm function and make daily tasks easier.
DhakaAges 18–60 - NCT07473505Recruiting
Nerve block for PTSD in special operations veterans
This study tests if a specific nerve block (cervical sympathetic block) can help reduce trauma-related symptoms in Special Operations veterans with PTSD. The goal is to see if this treatment is safe and can improve how you feel.
Strongsville, OhioAges 18 years+ - NCT02426255Recruiting
Study of serious injuries and complications after trauma
This study follows people with severe injuries (including head injuries and bleeding) to better understand serious complications that can happen after trauma. Your experience may help doctors predict and prevent these complications in the future.
AngersAges 15 years+ - NCT07105358Recruiting
Vision recovery study after brain damage
This study tests whether the brain can improve vision after damage caused by stroke, tumor, or injury. It may help people with vision loss from a brain lesion find new ways to see better.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07655310Recruiting
Parent factors and CT use in kids with minor head injury
This study looks at how a parent's background and understanding of health information might affect whether a child with a minor head injury gets a CT scan. It aims to better understand these factors to improve care.
BursaAges Up to 17 years - NCT05825027Recruiting
Sorting out risk in children with a recent concussion
This study looks at how to identify which children are at higher risk after a concussion and how they should be monitored. It may help doctors choose safer, more personalized follow-up care after a recent head injury.
Durham, North CarolinaAges 11–17 - NCT05343130Recruiting
Brain-controlled electrical therapy for arm mobility after spinal injury
This trial studies a brain-computer system that helps control electrical stimulation to improve arm movement after a spinal cord injury. It may help with functional use of the upper limbs during rehabilitation if you meet the specific injury, spasticity, and safety requirements.
Tlalpan, Mexico CityAges 18 years+ - NCT04708613Recruiting
Brain testing study for former football players and controls
This study looks at how the brain and thinking may be affected by playing professional football, using brain scans and thinking tests. It also compares former players with similar men who did not play organized football beyond high school.
Pittsburgh, PennsylvaniaAges 29–59 - NCT06747260RecruitingEarly Phase 1
Breast milk through the nose for HIE
This trial tests whether giving fresh breast milk through the nose is safe and possible for newborns with HIE (a brain injury from oxygen loss at birth) who are already receiving cooling therapy. It may help protect the brain and reduce injury.
BudapestAges Up to 2 days - NCT07097792Recruiting
Concussion recovery support program for headaches
This study tests a support program for young people who have had a concussion and are still having headaches. It aims to help them recover and feel better.
Seattle, WashingtonAges 18–29 - NCT05233475Recruiting
Rehab program after concussion in Danish adults
This trial tests a “get going” rehabilitation program for people who recently had a concussion (mild brain injury) from a head impact. It may help reduce concussion symptoms and improve day-to-day functioning in the months after injury.
Hammel, Deb´nmarkAges 18–60 - NCT07357090Recruiting
Carbon dioxide and brain waste clearance trial
This trial tests if breathing in carbon dioxide helps the brain clear waste. It may show how the brain heals after a traumatic brain injury (TBI).
Albuquerque, New MexicoAges 18–82 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT03053791Recruiting
Deep brain stimulation to improve walking after incomplete spinal injury
This study tests whether deep brain stimulation can improve walking in people with an incomplete spinal cord injury. It also requires that you meet specific injury and walking ability requirements and be able to attend study visits and training.
ZurichAges 18–75 - NCT04898491Recruiting
Pain behavior scale study for adults who cannot speak
This study checks whether a “pain behavior” checklist works well and gives consistent results in adults who can’t communicate verbally and who have an artificial airway. It may help clinicians better recognize pain in people who cannot tell them directly.
Madrid, MadridAges 18 years+
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 276 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.