Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07156175RecruitingPhase 2
Study of new treatment for microscopic colitis in remission
This study tests whether a new medication (SAR444336) can help adults with microscopic colitis stay in remission longer. It may be an option if you are already taking budesonide and have had flares in the past 8 months.
LeuvenAges 18 years+ - NCT07164313RecruitingPhase 1
ZW251 for advanced solid tumors
This trial is testing a new drug called ZW251 for people with advanced liver cancer (hepatocellular carcinoma), non-small cell lung cancer, or germ cell tumors that have spread or cannot be removed by surgery. It aims to see if the drug is safe and effective.
San Francisco, CaliforniaAges 18 years+ - NCT07157033RecruitingPhase 1/Phase 2
Testing XER-001 with radiation for advanced pancreatic cancer
This trial tests a new way to deliver a drug called amifostine (XER-001) alongside intense radiation therapy (SBRT) for people with locally advanced pancreatic cancer that can't be surgically removed. The goal is to see if it's safe and effective at protecting healthy tissue while targeting the tumor.
Duarte, CaliforniaAges 18 years+ - NCT06514573Recruiting
Butyrate supplement for children with autism and stomach issues
This study tests if a supplement called butyrate can help improve gut health in children aged 3-6 who have autism and ongoing stomach problems like constipation or bloating. It aims to see if this treatment eases their digestive symptoms.
NaplesAges 3–6 - NCT06954935Recruiting
Eye massage for nausea after gallbladder surgery
This study tests if a gentle massage around the eyes can help reduce nausea and vomiting after laparoscopic gallbladder removal. If you often feel sick after surgery, this might offer a drug-free way to feel better.
GaziantepAges 18–70 - NCT06316245Recruiting
Recovery after major gastrointestinal surgery
This study looks at how well you recover after major or intermediate surgery on your stomach, intestines, colon, or rectum. It measures your ability to do daily activities and how many days you spend at home (instead of the hospital) in the first 30 days after surgery.
Istanbul, FatihAges 18 years+ - NCT02961413Recruiting
Study of drug-related liver injury in China
This study follows people who developed liver injury from a medicine (not from other causes). It aims to better describe different types and severities of drug-related liver injury and may help improve how clinicians recognize and manage it.
ShanghaiAges Any age - NCT06949982RecruitingPhase 2
Comparing two treatments for advanced colorectal cancer with RAS mutations
This trial tests if a combination of hydroxychloroquine, methotrexate, capecitabine, and bevacizumab works better than regorafenib for people with metastatic colorectal cancer that has a RAS gene mutation and has stopped responding to at least two prior treatments.
Saint Petersburg, Sankt-PeterburgAges 18 years+ - NCT07147231RecruitingPhase 1/Phase 2
Pidnarulex plus cemiplimab for MSS colorectal cancer
This trial tests two drugs together: pidnarulex (a targeted therapy) and cemiplimab (an immunotherapy that helps your immune system fight cancer). It is for people with advanced colorectal cancer that is microsatellite stable (MSS) and has not responded to current treatments, especially if their tumor has a MYC or FBXW7 change.
Aurora, ColoradoAges 18 years+ - NCT07146256Recruiting
OPMD Natural History Registry Study
This study is building a national registry (a database) for people with Oculo-Pharyngeal Muscular Dystrophy (OPMD) in Israel. Joining will help researchers understand how OPMD progresses over time and may lead to better care.
Ramat GanAges 18 years+ - NCT07150624RecruitingPhase 4
Polyene phosphatidylcholine for liver injury after surgery
This trial tests whether a medicine called polyene phosphatidylcholine can help protect the liver from damage after surgery for liver cancer. It is for people who are having a specific type of keyhole surgery to remove part of the liver.
Hefei, AnhuiAges 18–70 - NCT07145151RecruitingPhase 2
Studying UBT251 for MASH liver disease
This trial tests a new medication called UBT251 for people with MASH, a type of liver disease linked to weight and metabolism. It aims to see if the medicine can reduce liver damage and scarring.
Beijing, Beijing MunicipalityAges 18–75 - NCT07148297Recruiting
Blood test for colorectal cancer detection
This study tests a new blood test that might help detect colorectal cancer. If you're already planning a colonoscopy or colorectal surgery, your participation could help improve early detection.
MendozaAges 45–75 - NCT07152405RecruitingPhase 3
New drug vs. chemo for HER2+ stomach cancer
This trial tests a new targeted drug, BL-M07D1, against standard chemotherapy for people with HER2-positive stomach or gastroesophageal junction cancer that has spread. The goal is to see if BL-M07D1 works better than standard chemo.
Harbin, HeilongjiangAges 18–75 - NCT07146100Recruiting
Long-term follow-up after AHB-137 treatment for hepatitis B
This study follows participants with chronic hepatitis B who previously responded to the drug AHB-137. The goal is to track long-term health and safety after their treatment.
Hefei, AnhuiAges 18 years+ - NCT07145255RecruitingPhase 1/Phase 2
Study of MBRC-201 for advanced solid tumors
This trial tests a new drug, MBRC-201, for people with advanced solid tumors that have not responded to standard treatments. The goal is to find the best dose and see if it helps shrink tumors or slow their growth.
San Francisco, CaliforniaAges 18 years+ - NCT07148128RecruitingPhase 1/Phase 2
Testing the safety of WEF-001 for KRAS-mutant cancers
This trial studies a new drug called WEF-001 for people with advanced cancers that have a KRAS mutation. It aims to see if the drug is safe and shrinks tumors when used alone.
Dallas, TexasAges 18 years+ - NCT07148310Recruiting
A blood and tissue test for liver cancer
This study is looking at a new way to find liver cancer by testing blood and tissue samples. It compares people with liver cancer to people with liver scarring (cirrhosis) but no cancer.
MendozaAges 18–75 - NCT07151040RecruitingPhase 1/Phase 2
Testing TH9619 for advanced solid tumors
This trial tests a new drug called TH9619 for people with advanced cancers of the colon, head and neck, lung, or stomach. It aims to see if the drug is safe and works against tumors that have already been treated with chemotherapy.
VillejuifAges 18 years+ - NCT07148739RecruitingPhase 4
Ensuring Best Access to CF Treatment
This study tests whether people with cystic fibrosis who are already on a triple combination CFTR modulator can stay on their treatment without interruptions or problems. It aims to make sure everyone gets the best, most consistent treatment for their CF.
Birmingham, AlabamaAges 3 years+ - NCT07147335Recruiting
Blood test for early liver cancer warning in cirrhosis
This study looks at whether a blood test for a protein called AKR1B10 can help give early warning of liver cancer (hepatocellular carcinoma) in people with cirrhosis. If you have cirrhosis or chronic hepatitis and are between 18 and 75 years old, you may be able to join.
Hengyang, HunanAges 18–75 - NCT07148492Recruiting
Stitch to prevent reflux after gastric bypass
This trial tests adding an antireflux stitch to a type of gastric bypass surgery to see if it helps reduce acid reflux. It may help patients who are already scheduled for this surgery.
Peshawar, KhyberpukhtunkhwaAges Any age - NCT07148830Recruiting
Surgery technique study for pancreatic cancer patients
This trial tests a specific surgical method called mesopancreatic excision during Whipple surgery for pancreatic cancer. It may help remove more cancer tissue and improve outcomes for patients with resectable disease.
Minya, Minya GovernorateAges 18–75 - NCT07149675Recruiting
Long-term study for primary biliary cholangitis patients
This study tracks patients with primary biliary cholangitis (PBC) over time to understand long-term outcomes. It aims to gather information that could improve care and management for people with PBC.
Beijing, Select A State Or ProvinceAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.