Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07159048Recruiting
Heat therapy for liver tumors
This trial tests a heat-based treatment for liver cancer tumors that uses multiple methods to destroy cancer cells. It may help people with liver tumors that haven't spread and who are healthy enough for treatment.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07162701Recruiting
Body composition study for inflammatory bowel disease
This study looks at body composition (fat and muscle) in people with Crohn's disease or ulcerative colitis. It tests if a new way to monitor body changes can help guide treatment with biologic or JAK inhibitor medicines.
BarcelonaAges 18–64 - NCT07161245Recruiting
Fatigue relief study for primary biliary cholangitis
This trial tests a program of exercise, nutrition, and education to help reduce fatigue in people with primary biliary cholangitis. It aims to see if this program can improve energy and quality of life.
Barcelona, BarcelonaAges 18–80 - NCT07155616Enrolling by invitation
Blood flow measurement from CT scan before Whipple surgery
This study uses a computer tool to measure blood flow in the arteries from your CT scan before a Whipple procedure. It may help doctors better plan your surgery.
Barcelona, BarcelonaAges 18 years+ - NCT07155525Recruiting
Glue to prevent leaks after pancreas surgery
This trial tests whether a special medical glue (Glubran® 2) applied to the pancreas during surgery can help prevent fluid leaks. It is for people undergoing a Whipple procedure for pancreatic cancer who have a soft pancreas.
Minya, Minya GovernorateAges 18–75 - NCT07164651Enrolling by invitation
Faster MRI for diagnosing belly pain in children
This study is testing a faster MRI technique for children with abdominal pain. It uses artificial intelligence to make the MRI quicker, which may be more comfortable for the child while still giving clear images of the abdomen.
Wuhan, HubeiAges 3–18 - NCT07161869Recruiting
Lymph node check before surgery for bile duct cancer
This study looks at how well a special ultrasound-guided biopsy checks lymph nodes before surgery or liver transplant for bile duct cancer. The goal is to see if this method accurately shows whether the cancer has spread to nearby lymph nodes.
Rotterdam, South HollandAges 18 years+ - NCT07163403RecruitingPhase 1
Preventing cancer in Lynch syndrome carriers with dendritic cell vaccine
This trial tests whether a personalized vaccine made from your own immune cells can help prevent cancer in people with Lynch syndrome. You must have no history of cancer and be willing to have regular colonoscopies.
Barcelona, BarcelonaAges 18 years+ - NCT07158008Recruiting
Weight loss surgery for people with obesity and heartburn
This study compares two weight-loss surgeries for people who have both obesity and severe heartburn or GERD. One surgery combines part of the stomach removal with an anti-reflux wrap, while the other reroutes the stomach to help with weight loss and reflux.
KrakowAges 18–65 - NCT07161960Recruiting
Early vs. delayed gallbladder removal after drainage
This trial compares removing the gallbladder early (within a few days) versus waiting several weeks after a drainage tube is placed. It aims to find the best timing for surgery in people with moderate to severe gallbladder inflammation.
Chiang MaiAges 20 years+ - NCT07156058Recruiting
Personalized therapy after surgery for bile duct cancer
This trial uses a test called MiniPDX, which grows a tiny sample of your tumor in mice to see which drugs work best. After your surgery, you'll receive chemotherapy chosen specifically for your cancer to help prevent it from coming back.
BeijingAges 18 years+ - NCT07158164RecruitingPhase 4
Genetic testing for chemotherapy dose adjustment
This trial checks if adjusting the dose of chemotherapy drugs 5-FU or capecitabine based on your DPYD genetic results can improve safety and effectiveness. It’s for people with cancer who are about to start these drugs for the first time.
Belleville, New JerseyAges 18 years+ - NCT07159022Recruiting
High-flow nasal oxygen vs mask for people with belly fat having sedated stomach scope
This study compares two ways of giving oxygen during a sedated gastroscopy for people with visceral obesity (extra belly fat). One method uses a high-flow nasal cannula, the other a face mask. The goal is to see which keeps oxygen levels more stable.
ShanghaiAges 18–80 - NCT07159711Recruiting
Heart monitoring study for esophageal cancer surgery
This study tests a non-invasive heart monitor (seismocardiography) to see if it can predict how well patients recover after esophageal cancer surgery. The goal is to improve surgical planning and outcomes.
GuildfordAges 18 years+ - NCT07162714RecruitingPhase 2
Short-course radiation plus AK112 for mismatch repair-proficient rectal cancer
This trial tests a new immunotherapy drug (AK112) given after a short course of radiation. It is for people with a specific type of mid-low rectal cancer that has not spread and has not been treated before.
Hangzhou, ZhejiangAges 18–75 - NCT07159334Recruiting
Lidocaine vs Nitroglycerin for Pain After Hemorrhoid Surgery
This study compares a lidocaine ointment versus a nitroglycerin (GTN) ointment for pain relief after hemorrhoid removal surgery. It aims to see which works better for patients with advanced hemorrhoids.
Lahore, Punjab ProvinceAges 18–60 - NCT07159581Enrolling by invitation
Gene therapy for Wilson disease study with PET scans
This trial uses a special PET scan with a copper tracer to see how well gene therapy is working in people with Wilson disease. It may help doctors understand if the treatment is helping your body handle copper properly.
Aarhus, Aarhus NAges 18 years+ - NCT07161765Enrolling by invitation
Straining and bowel issues in bleeding hemorrhoids
This study looks at how problems with bowel movements and straining relate to bleeding hemorrhoids. It may help find better ways to treat these symptoms.
Ann Arbor, MichiganAges 18 years+ - NCT07163689Recruiting
TIPS for liver disease with portal hypertension
This trial compares patients who have a rare liver condition (porto-sinusoidal vascular disease) with those who have cirrhosis, to see how a procedure called TIPS (a shunt placed in the liver to reduce blood pressure) works for complications like bleeding, fluid buildup, or blood clots.
Amiens, PicardieAges 18 years+ - NCT07161479Recruiting
Comparing two ways to remove small stomach growths
This study compares two ways to remove tiny, non-cancerous stomach growths—using a gentle heat tool (argon plasma coagulation) or a special scope to cut them out. The goal is to see which method is safer and works better.
Goyang-siAges 20 years+ - NCT07157969RecruitingPhase 2
Immunotherapy and anti-VEGF with or without local therapy for liver cancer
This trial tests a combination of immunotherapy (checkpoint inhibitors) and anti-VEGF therapy (which blocks blood vessel growth to tumors) with or without local treatments (like chemoembolization) for advanced liver cancer. It aims to see if the combination works better than current treatments.
BeijingAges 18 years+ - NCT07162337Recruiting
Diet education to lower colon cancer risk after polyp removal
This study tests whether a diet education program can change the balance of gut bacteria and bile acids to lower the risk of colorectal cancer in people who have had polyps removed.
Boston, MassachusettsAges 18–80 - NCT07157033RecruitingPhase 1/Phase 2
Testing XER-001 with radiation for advanced pancreatic cancer
This trial tests a new way to deliver a drug called amifostine (XER-001) alongside intense radiation therapy (SBRT) for people with locally advanced pancreatic cancer that can't be surgically removed. The goal is to see if it's safe and effective at protecting healthy tissue while targeting the tumor.
Duarte, CaliforniaAges 18 years+ - NCT07158242RecruitingPhase 3
Study of a Medication for Children with Active Ulcerative Colitis
This study is testing an investigational medication for children with ulcerative colitis that has not responded well to standard treatments. It aims to see if the drug is safe and effective in reducing symptoms.
Aurora, ColoradoAges 2–17
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.