Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,890 recruiting studies in this area right now.
By phase
- Not applicable4,918
- Phase 21,185
- Phase 1582
- Phase 3465
- Phase 1/Phase 2393
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer491
- Gastric Cancer296
- Pancreatic Cancer290
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer97
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona177
- Texas149
- Florida133
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,890 total
- NCT06553651Recruiting
Freezing tool to remove dead pancreas tissue
This trial tests a new freezing tool to remove dead tissue from the pancreas after acute pancreatitis. It might help you if you have a large, painful collection of dead tissue that needs to be cleaned out through a tube down your throat.
Boston, MassachusettsAges 18 years+ - NCT06553885RecruitingPhase 2
Study of enfortumab vedotin for advanced colorectal or liver cancer
This trial tests a drug called enfortumab vedotin for people whose colorectal or liver cancer has spread or cannot be removed and has stopped responding to or is intolerant to standard treatments. The drug is given through a vein and works by targeting cancer cells.
Tampa, FloridaAges 18 years+ - NCT06555003RecruitingPhase 3
DEBIRI plus chemo vs. chemo alone for liver metastases
This trial tests if a treatment called DEBIRI (tiny beads delivering chemo directly to the liver) plus standard chemotherapy works better than chemotherapy alone for colorectal cancer that has spread to the liver and can't be fully removed by surgery.
Tehran, Tehran ProvinceAges 18 years+ - NCT06555042Recruiting
Crohn's disease imaging study with PET-MRI
This study uses a special PET-MRI scan to look at inflammation and blood flow in the small intestine of people with Crohn's disease. It may help doctors better understand disease activity in the gut.
Turku, Southwest FinlandAges 18–70 - NCT06555471RecruitingPhase 2
Sintilimab plus chemo-radiation for older adults with advanced stomach cancer
This trial tests whether adding the immunotherapy drug sintilimab to standard chemoradiotherapy can help people aged 75 or older with locally advanced stomach cancer. It aims to shrink tumors and improve outcomes.
Nanjing, JiangsuAges 75 years+ - NCT06557668Recruiting
Immunomodulator plus cancer therapy for colorectal cancer
This study looks at how well a type of drug called an immunomodulator, given together with other cancer treatments, works for people with colorectal cancer. It aims to see if combining these therapies can improve outcomes.
TaichungAges 20 years+ - NCT06558227RecruitingPhase 2
ZG005 with bevacizumab vs sintilimab with bevacizumab for advanced liver cancer
This trial tests a new drug combination (ZG005 plus bevacizumab) against a standard combination (sintilimab plus bevacizumab) in people with advanced liver cancer that has spread or cannot be surgically removed. The goal is to see which combination works better and is safe.
Chengdu, SichuanAges 18–75 - NCT06558773RecruitingPhase 2
New drug combo for previously treated colorectal cancer
This trial tests a combination of a GSL synthesis inhibitor, an immunotherapy drug, and/or regorafenib in people with a specific type of colorectal cancer (pMMR/MSS) that has not responded to at least two prior treatments. The goal is to see if this new approach can help shrink or control the cancer.
Beijing, Biotherapeutic Department of Chinsese PLA Gereral HospitalAges 18–75 - NCT06558786Recruiting
Registry for esophageal cancer that has spread to a few spots
This study tracks patients with stage IV esophageal or gastroesophageal junction cancer that has spread to only a limited number of places (like the liver, lung, or a few lymph nodes). The goal is to understand how well treatments like surgery or radiation work after initial drug therapy.
New York, New YorkAges 18 years+ - NCT06559059Recruiting
Virtual cancer program for Veterans with new cancer
This study looks at how well a virtual (telemedicine) cancer program works for Veterans who are newly diagnosed with lung, prostate, breast, or colon cancer. Participation involves a telemedicine visit at a VA medical center instead of traveling to the hospital.
Brooklyn, New YorkAges 18 years+ - NCT06559761Recruiting
Imaging to predict liver cancer aggressiveness after surgery
This study looks at whether special scans can help doctors better predict how aggressive a person's liver cancer (hepatocellular carcinoma) will be, especially right after surgery. If you are planning to have surgery to remove the tumor as your first treatment, this trial might be a good fit.
Beijing, Beijing MunicipalityAges 18–80 - NCT06560307Recruiting
Enhanced stimulation for gastroparesis relief
This trial tests a new way to program an implanted device (Enterra®) to better treat severe nausea and vomiting caused by gastroparesis. If you have frequent nausea and vomiting despite other treatments, this study might help find a better setting for your device.
Tampa, FloridaAges 18–70 - NCT06560528RecruitingPhase 2
Drug combo before & after surgery for HER2+ stomach cancer
This trial tests a combination of three drugs (targeted therapy, immunotherapy, and chemotherapy) before and after surgery for locally advanced HER2-positive stomach cancer. It aims to see if this treatment can improve outcomes for patients whose cancer has not yet spread.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06560671Recruiting
App vs. paper for colonoscopy prep education
This study compares a new smartphone app to standard paper instructions for helping patients get their bowel ready for colonoscopy. It aims to see which method is easier to understand and leads to a better exam.
HsinchuAges 18 years+ - NCT06561178Recruiting
Blood Test to Monitor Esophageal Cancer After Surgery
This trial looks at whether a personalized blood test can detect cancer returning after surgery for esophageal cancer. It tests people who had chemoradiotherapy before surgery and still had some cancer remaining in the removed tissue. The goal is to use the blood test to catch any remaining or returning cancer early.
Guangzhou, GuangdongAges Any age - NCT06561399Recruiting
Triple therapy followed by radiation for liver cancer
This trial tests whether adding targeted radiation therapy can help people with liver cancer that cannot be surgically removed. It is for people who have already received a combination of TACE, lenvatinib, and sintilimab and whose tumors have not grown.
Fuzhou, FujianAges 18–75 - NCT06562140Recruiting
Study of health in colorectal and anal cancer patients
This study looks at the overall health and well-being of people with colorectal or anal cancer. It may help doctors better understand how to support patients like you.
Pécs, BaranyaAges 18–80 - NCT06562361RecruitingEarly Phase 1
Trial of a radioactive tracer for liver and gut diseases
This early-phase trial tests a new radioactive tracer to see how it binds in healthy people and in patients with fatty liver disease (MASH), Crohn's disease, or primary sclerosing cholangitis. The goal is to learn if the tracer can help detect or monitor these conditions.
StockholmAges 18–75 - NCT06562348RecruitingPhase 2
ctDNA monitoring test for metastatic GI cancer treatment
This trial tests whether using a ctDNA blood test along with standard CT scans can help guide treatment decisions for people with incurable metastatic gastrointestinal cancer. It may help doctors decide sooner whether a treatment is working.
AarhusAges 18 years+ - NCT06562543RecruitingPhase 4
Fruquintinib for advanced colorectal cancer in minority populations
This trial tests a medication called fruquintinib (an oral pill) for people with advanced colorectal cancer that has not responded to prior treatments. It is specifically looking for participants who identify as Black or African American and/or Hispanic or Latino to help understand how the drug works in these groups.
Birmingham, AlabamaAges 18 years+ - NCT06562803Recruiting
Cleaning the blood for liver failure with sepsis
This trial tests if a special blood-filtering method combined with plasma exchange can help people with severe liver failure and sepsis. It aims to reduce inflammation and improve survival.
Guangzhou, GuangdongAges 18–70 - NCT06563349RecruitingPhase 4
Magnesium study for kids having appendix surgery
This trial tests if magnesium sulfate can help children recover better after laparoscopic appendix removal. It aims to see if it reduces pain or other problems during and after surgery.
WarsawAges 1.5 years–18 years - NCT06563388RecruitingPhase 3
SABR for limited metastatic cancer (ID-COMET trial)
This study tests a precise radiation technique called SABR to treat cancer that has spread to a few spots. It aims to see if this approach can help control the cancer better than usual treatment, especially for lung, prostate, colorectal, or other solid tumors with limited spread.
Buffalo, New YorkAges 1 year+ - NCT06563869RecruitingPhase 3
Sintilimab with chemo and growth factor before esophageal cancer surgery
This trial tests whether giving the immunotherapy drug sintilimab together with standard chemotherapy and a growth factor injection before surgery can help people with a certain type of esophageal cancer (squamous cell carcinoma) that is still removable. The goal is to improve treatment outcomes before the operation.
Nanjing, JiangsuAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,890 recruiting gastroenterology studies from the U.S. registry right now, out of 12,399 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.