Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07169799Recruiting
Freezing spray for GAVE stomach bleeding
This study tests a freezing spray (Tru-Freeze) to treat GAVE, a condition that causes stomach bleeding. It may help people who need blood transfusions because of GAVE and have had few or no prior endoscopic treatments.
Jacksonville, FloridaAges 18 years+ - NCT07170345Recruiting
AI to detect hidden spread in liver cancer from scans
This trial uses a computer program to help doctors find signs of microscopic tumor spread in blood vessels (microvascular invasion) from liver cancer images. It aims to improve treatment planning for patients who are having surgery.
Fuzhou, FujianAges 18–18 - NCT07170748Recruiting
Testing a new blood test for HIV, hepatitis B/C, and syphilis
This study evaluates a new blood test that checks for HIV, hepatitis B, hepatitis C, and syphilis all at once. It is designed to see how well the test works in different groups of people, including those with known infections and those without.
AbidjanAges 18 years+ - NCT07171203RecruitingPhase 1
Imatinib and fampridine before surgery for KIT-mutant GIST
This trial tests whether combining two oral medications, imatinib and fampridine, before surgery can shrink GIST tumors that have a specific KIT gene mutation. The goal is to improve surgical outcomes and potentially reduce the risk of the tumor coming back.
La Jolla, CaliforniaAges 18 years+ - NCT07171554Recruiting
A test to find the best drugs for advanced colorectal cancer
This trial uses a special test to help choose which drugs might work best for you if you have metastatic colorectal cancer that has stopped responding to first treatment. The goal is to match you with a more effective next therapy.
Lørenskog, AkershusAges 18 years+ - NCT07172555Recruiting
Virtual diet check-ins for coeliac disease
This study tests if virtual appointments with a dietitian can help manage coeliac disease. It compares different ways of providing diet support to find what works best for patients.
Sheffield, South YorkshireAges 18 years+ - NCT07172802RecruitingPhase 1/Phase 2
Study of GI-108 for advanced solid tumors
This trial tests a new drug called GI-108, which is designed to help your immune system fight cancer. It is for people with advanced or metastatic solid tumors that have not responded to other treatments.
SeoulAges 18 years+ - NCT07173257Recruiting
Survey study after pancreas surgery
This study asks patients to fill out surveys after pancreas surgery to understand their outcomes and recovery. It may help improve care for future patients.
Phoenix, ArizonaAges 18 years+ - NCT07173985Recruiting
Mailed colon cancer screening in Appalachia
This trial sends home a stool-based screening test to people in Appalachian counties. It aims to find the best way to help more people get screened for colon cancer.
Columbus, OhioAges 45–74 - NCT07174570RecruitingPhase 2
Celecoxib with immunotherapy for advanced liver cancer
This trial tests a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus a pain reliever (celecoxib) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if this three-drug combination works better than standard treatments.
Atlanta, GeorgiaAges 18 years+ - NCT07174609Recruiting
Scrambler therapy for chronic pancreatitis pain
This study tests a non-invasive pain treatment called scrambler therapy for people with chronic pancreatitis. It uses mild electrical signals on the skin to try to reduce long-term belly pain.
Baltimore, MarylandAges 18 years+ - NCT07175155Recruiting
Breathing device and oxygen for endoscopy in severe obesity
This study tests a special breathing device (a tube placed in the throat) combined with high-flow oxygen through the nose during sedation for endoscopy in people with severe obesity. It aims to see if this combination helps keep oxygen levels stable and makes the procedure safer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07175272RecruitingPhase 2/Phase 3
Holy basil for treating stomach discomfort (dyspepsia)
This study tests whether the herb holy basil can help relieve chronic stomach discomfort (dyspepsia) without the side effects of standard acid-reducing drugs. If you have ongoing upper belly pain and are not on certain medications, this trial may offer a natural alternative.
Bangkok Noi, BangkokAges 18 years+ - NCT07176078Recruiting
Osteopathic care plus low-FODMAP diet for fibromyalgia and IBS
This trial tests whether adding osteopathic care (a hands-on therapy) to a low-FODMAP diet helps people with both fibromyalgia and irritable bowel syndrome feel better. It compares the diet alone to the diet plus osteopathic sessions.
Brussels, Brussels CapitalAges 18 years+ - NCT07176182RecruitingPhase 2
Chemotherapy with alvenor for rectal cancer with high YWHAB
This trial tests adding the drug alvenor to standard chemotherapy before surgery for rectal cancer patients whose tumors have high levels of a protein called YWHAB. The goal is to see if this combination can improve treatment outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07176312RecruitingPhase 2
Zanidatamab with pembrolizumab and chemo for HER2+ and PD-L1+ stomach cancer
This trial tests a new combination of targeted therapy (zanidatamab), immunotherapy (pembrolizumab), and chemotherapy for people with HER2-positive and PD-L1-positive advanced stomach or gastroesophageal cancer. It aims to see if this combination is more effective than current treatments.
BerlinAges 18 years+ - NCT07176650RecruitingPhase 1
Testing a biosimilar ipilimumab for advanced liver cancer
This trial tests a new version of the immunotherapy drug ipilimumab (called HLX13) against the approved version (YERVOY) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if the new version works similarly and is as safe.
Glendale, CaliforniaAges 18–65 - NCT07176923RecruitingEarly Phase 1
Gene editing for familial chylomicronemia syndrome (FCS)
This study tests a new gene-editing treatment called CS-121 for people with FCS whose triglycerides remain very high despite standard therapy. It aims to lower triglyceride levels by editing the APOC3 gene.
Hefei, AnhuiAges 18–55 - NCT07176962Recruiting
Blood test for early detection of bile duct cancer
This study is testing a new blood test that looks for signs of DNA changes linked to biliary tract cancer. It aims to see if the test can find these cancers early. If you have biliary tract cancer or a high suspicion of it, you may be able to help.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07177742Recruiting
Study of protein in blood to predict liver spread of colon cancer
This study looks at whether a substance in your blood (called PRDX1, found in tiny particles called exosomes) can help predict if colon cancer will spread to the liver after surgery. It may help doctors understand who needs more monitoring or treatment.
Shanghai, Shanghai MunicipalityAges 1.6 years–6.7 years - NCT07177794RecruitingPhase 3
Toripalimab and capecitabine after chemoradiotherapy for esophageal cancer
This trial tests whether adding the immunotherapy drug toripalimab and the chemotherapy pill capecitabine after standard chemoradiotherapy can help prevent esophageal cancer from coming back. It's for people with squamous cell esophageal cancer that hasn't spread far and who have just finished chemoradiotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07178093Recruiting
Mushroom extract for liver cancer after TACE
This trial is testing if an extract from a medicinal mushroom (Antrodia cinnamomea) can help people with liver cancer who have had a treatment called TACE (chemoembolization). It looks at whether the mushroom extract can improve liver health and recovery after the procedure.
Taichung, TaiwanAges 20–80 - NCT07178587Recruiting
New PET scan for liver and neuroendocrine tumors
This trial tests a new PET imaging method that uses two different tracers to find and stage liver cancer (HCC) or neuroendocrine tumors (GEP-NET) more accurately. It may help doctors decide on the best treatment for you.
BrestAges 18 years+ - NCT07179237RecruitingPhase 2
Testing carminal for H. pylori stomach infection
This trial tests a new medicine called carminal for people with stomach inflammation caused by H. pylori bacteria. It aims to see if the drug can help improve symptoms like indigestion and get rid of the infection.
Belgrade, Central SerbiaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.