Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06478108RecruitingPhase 2/Phase 3
Software-guided multi-immunotherapy for solid tumors
This trial tests a new software-guided approach to deliver multiple immunotherapy drugs directly into the liver for people with solid tumors. It aims to see if this method can shrink tumors and improve survival.
Guangzhou, GuangdongAges 18–75 - NCT06478225Recruiting
Cell therapy for advanced pancreatic cancer
This trial tests a new cell therapy (BGT007H) for people with advanced pancreatic cancer that has not responded to earlier treatments. The goal is to see if it is safe and can help shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07822529Recruiting
Long-term study of Tremfya for inflammatory bowel disease
This study follows adults with moderate-to-severe Crohn's disease or ulcerative colitis who are starting treatment with guselkumab (Tremfya). It aims to see how well the medication works and how long the effects last over time.
AmiensAges 18 years+ - NCT07824583Recruiting
New radiation treatment for chest and upper abdomen tumors
This trial tests a new radiation treatment workflow that guides the radiation beam more precisely when you hold your breath. It may help target tumors in the chest or upper belly while sparing healthy tissue.
St Louis, MissouriAges 21 years+ - NCT07820085RecruitingPhase 2/Phase 3
Oral treatment for light sensitivity in EPP and XLP
This study tests an oral medication, PORT-77, to reduce pain and sensitivity to sunlight in people with EPP or XLP. It may help those who experience symptoms shortly after sun exposure.
Huntington Beach, CaliforniaAges 12 years+ - NCT07823049RecruitingPhase 3
Study of XNW28012 for advanced pancreatic cancer after prior treatments
This trial tests a new drug, XNW28012, for people with advanced pancreatic cancer that has worsened after two standard chemotherapy treatments. The drug targets a protein called tissue factor on cancer cells, which might help slow or stop the cancer's growth.
Shanghai, Shanghai MunicipalityAges Any age - NCT07822087RecruitingPhase 1
Cell therapy for active crohn's disease
This trial tests an experimental cell therapy called ATORM-C for people with Crohn's disease who haven't gotten better with standard treatments. The goal is to see if this new treatment can help heal the intestinal ulcers that cause symptoms.
SeoulAges 19–80 - NCT07817758Recruiting
Sarcopenia and surgery outcomes in older gastrointestinal cancer patients
This trial looks at whether low muscle mass (sarcopenia) before surgery affects recovery for older adults with gastrointestinal cancer. It may help doctors personalize care and improve outcomes.
Van, VanAges 60 years+ - NCT07820696Recruiting
Laxative before colon surgery for easier operation
This study tests whether taking a laxative before planned colon surgery makes the surgery easier for the surgeon, which might lead to a smoother recovery. If you are scheduled for this type of surgery and are generally healthy, you may be able to join.
Van, VanAges 18 years+ - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT06476054Recruiting
Timing of gallbladder removal after drainage for severe inflammation
This study looks at the best time to remove the gallbladder after a drainage procedure for severe gallbladder inflammation. It helps doctors decide when surgery is safest and most effective for you.
LleidaAges 18 years+ - NCT06454448RecruitingPhase 1/Phase 2
Adebrelimab plus chemotherapy for advanced pancreatic cancer
This trial tests a combination of a targeted immune therapy (Adebrelimab) with three chemotherapy drugs for people with metastatic pancreatic cancer who haven't had any treatment yet. The goal is to see if this combination can shrink tumors and help people live longer.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT04622410Recruiting
Hirschsprung disease patient registry study
This study keeps a research record of people who have Hirschsprung disease and have had surgery. It helps doctors better understand long-term outcomes and care needs for future patients.
LeuvenAges Up to 18 years - NCT04623580Recruiting
Hernia surgery registry for adults after groin hernia repair
This is a registry that collects health information from adults who have surgery for an inguinal or femoral groin hernia, whether planned or urgent, and whether it’s a first-time or recurrent hernia. It helps doctors better understand hernia care and outcomes for patients over time.
LeuvenAges 18 years+ - NCT07817706Recruiting
A new noninvasive test for small bowel sensation
This study is developing a new, noninvasive test to measure how the small intestine senses stimulation. It aims to create a 'small intestine stress test' that may help better understand and someday diagnose gut sensitivity issues.
Rochester, MinnesotaAges 18–75 - NCT07823803Recruiting
Comparing two ways to remove the gallbladder in keyhole surgery
This trial compares two different methods for removing the gallbladder during laparoscopic (keyhole) surgery. It aims to see if one method causes fewer problems or is easier for patients like you.
Islamabad, FederalAges 20–70 - NCT07824999Recruiting
Sutureless hemorrhoidectomy versus standard ligation for advanced hemorrhoids
This trial compares two surgical approaches for advanced (grade III or IV) hemorrhoids. One is a newer sutureless technique and the other the standard ligation (tying) method. It aims to see which provides better relief from symptoms like bleeding and pain.
SohagAges 18 years+ - NCT07824908Recruiting
Numbing medicine and pain after keyhole appendix removal
This study looks at whether the place where the appendix is taken out during keyhole surgery and the use of numbing medicine can help reduce pain after the operation. If you're having this emergency surgery, you may have less pain afterward.
Diyarbakır, KayapınarAges 18 years+ - NCT07824479Recruiting
Pre-surgery immunotherapy for advanced stomach cancer
This study tests whether giving immunotherapy before surgery can help shrink advanced stomach cancer and improve outcomes. Immunotherapy uses your body's own immune system to fight cancer cells.
ShanghaiAges 18–80 - NCT07818018RecruitingPhase 1/Phase 2
Study of 2141-V11 for esophageal, stomach, or junction cancer
This trial tests a new drug called 2141-V11 in people with advanced esophageal, stomach, or gastroesophageal junction cancer. It aims to see if adding this drug to your current treatment can help control the cancer better.
Basking Ridge, New JerseyAges 18 years+ - NCT07824791Recruiting
Predicting return of Crohn's disease after bowel surgery
This study looks at what happens to people with Crohn's disease after they have surgery to remove a diseased part of their intestine. The goal is to find patterns or signs that might help predict whether the disease will come back, which could help doctors plan better follow-up care.
Guangzhou, GuangdongAges 18–70 - NCT07825129Enrolling by invitation
Protective device for rectal and lower colon tumor surgery
This trial tests a disposable device that isolates and protects the intestines during laparoscopic surgery for tumors in the rectum or lower sigmoid colon. It may help reduce complications and improve recovery after surgery.
Beijing, Xicheng DisAges 22 years+ - NCT07820644Recruiting
Liver cancer risk prediction in chronic liver disease
This study aims to predict the risk of developing liver cancer in people with chronic liver conditions such as hepatitis B or C, cirrhosis, or fatty liver disease. By participating, you may help researchers improve early detection and prevention strategies for liver cancer.
Shenzhen, GuangdongAges 18–75 - NCT07820800Recruiting
Personalized digital health guidance for middle-aged adults
This study tests whether a digital health app can help middle-aged adults based on their personal metabolic risk. It aims to prevent diseases by providing tailored guidance.
SavonlinnaAges 45–55
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.