Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT03675672RecruitingPhase 4
Preventing repeat bleeding from stomach or upper gut ulcers
This trial studies medicines to help stop bleeding from coming back after you’ve had an “idiopathic” stomach/upper gut ulcer bleed. It may help by reducing ulcer re-bleeding risk in people who don’t have common causes like H. pylori or common ulcer-triggering drugs.
Hong KongAges 18 years+ - NCT07172035Recruiting
TIPS and liver recovery in decompensated cirrhosis
This trial studies whether a procedure called TIPS (a stent placed in the liver to improve blood flow) can help people with advanced liver disease regain better liver function. It is for patients who have had complications like severe bleeding from the stomach or difficult-to-control fluid buildup (ascites).
ChangshaAges 18–80 - NCT06756672Recruiting
Helping with recovery in laparoscopic colorectal surgery
This study looks at how a system called HPI (a way to track your body's response during surgery) might help people recover better after laparoscopic colorectal surgery. It is for people having this planned surgery who do not have serious heart or lung problems.
TaipeiAges 20 years+ - NCT07142798Enrolling by invitation
14-day triple therapy for H. pylori infection
This trial tests a 14-day treatment using bismuth, amoxicillin, and a stomach acid reducer (PCAB) to see how well it clears H. pylori, a bacteria that can cause stomach ulcers. It may be an option if you have H. pylori and haven't had stomach surgery or certain serious health conditions.
Kaohsiung CityAges 18–80 - NCT03516461Recruiting
Fecal transplant study for bowel injury after radiation
This study tests whether transferring stool bacteria (a fecal microbiota transplant) can improve “radiation enteritis,” a bowel problem that happens after radiation treatment. It may help restore gut bacteria and reduce symptoms after your radiation therapy.
Nanjing, JiangsuAges 18–85 - NCT06205862RecruitingPhase 2
Fecal transplant for preventing colon polyp return
This study tests whether taking capsules of healthy bacteria (fecal microbiota transplant) can help prevent colon polyps from coming back after they have been removed. It might be an option for people who have had an adenoma polyp removed and want to reduce the chance of recurrence.
Guangzhou, GuangdongAges 18–75 - NCT02989818Recruiting
Study of an endoscopy procedure called ESD
This trial evaluates how useful a procedure called ESD is for patients as part of routine care. ESD is done during an endoscopy, and the study checks whether it works well and is helpful in the real world.
Gainesville, FloridaAges 18–100 - NCT06472037RecruitingPhase 2
AG chemo plus immunotherapy and short radiation for locally advanced pancreatic cancer
This trial tests a combination of two chemotherapy drugs (AG) plus an immunotherapy (cadonilimab) and a short course of radiation for people with locally advanced pancreatic cancer that hasn't been treated yet. The goal is to see if this approach helps shrink or control the tumor.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06475196Enrolling by invitation
Immunotherapy plus chemo before surgery for esophageal cancer
This trial tests a combination of immunotherapy (sintilimab) and chemotherapy given before surgery for esophageal cancer that can be surgically removed. The goal is to see if this approach helps shrink tumors and improve outcomes.
Xi'an, ShaanxiAges 18–75 - NCT06654219Recruiting
Clear liquids before endoscopy for patients on GLP-1 meds
This study tests whether drinking only clear liquids before an upper endoscopy can reduce leftover stomach contents in people taking GLP-1 medications (like Ozempic or Mounjaro). It may help make the procedure safer.
Houston, TexasAges 18 years+ - NCT06489197RecruitingPhase 2
AK112 plus chemo for advanced esophageal cancer
This trial tests a new immunotherapy drug (AK112) combined with chemotherapy as a first treatment for advanced esophageal cancer that has spread or cannot be removed. It aims to see if this combination helps shrink tumors and controls the disease longer than chemotherapy alone.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06468865Recruiting
Glucose monitoring for low blood sugar after gastric bypass
This trial tests whether a new way of using glucose monitoring can help manage low blood sugar that happens after meals in people who have had gastric bypass surgery. It aims to find better ways to track and treat these episodes.
Tønsberg, VestfoldAges 18 years+ - NCT07119346Recruiting
Nerve block for pain after feeding tube surgery in children
This trial tests whether a nerve block (EOI) given before surgery can reduce pain after a feeding tube procedure in children. It aims to help kids recover more comfortably.
SeoulAges 3–17 - NCT03039309Recruiting
Testing endoscopic removal for early stomach or gut growth
This study looks at endoscopic submucosal dissection, a procedure to remove early growths in the stomach or other parts of the GI tract, using the UK approach. You may benefit by having your treatment guided within a research study and closer follow-up.
PortsmouthAges 18 years+ - NCT06451432Recruiting
Laparoscopic vs. open hernia repair in children
This trial compares two ways to repair a hernia in children: laparoscopic surgery (using a small camera) and open surgery (a traditional cut). It aims to see which is more effective and cost-effective.
Veldhoven, North BrabantAges birth–16 years - NCT06215716RecruitingPhase 3
Efruxifermin for NASH/MASH with liver scarring
This study tests a new medicine, efruxifermin, for people with NASH/MASH (fatty liver disease) and moderate liver scarring. It aims to see if the drug can help improve the liver's condition.
Birmingham, AlabamaAges 18–80 - NCT07440511Recruiting
Spleen stiffness test for advanced liver scarring
This study tests a new way to measure liver scarring using a non-invasive ultrasound of the spleen (spleen stiffness measurement). It's for people with fatty liver disease (MASLD) who have advanced fibrosis (scarring) to see if this method can accurately detect the severity of liver damage.
RomeAges 18 years+ - NCT03310905Recruiting
Abdominal wall transplant for people needing multi-organ transplant
This study evaluates an abdominal wall transplant (replacing the front belly/tissue) done along with another organ transplant. It may help people who need a specialized transplant approach, but it’s only for certain candidates at Duke who meet strict safety and cancer, pregnancy, and anesthesia requirements.
Durham, North CarolinaAges 18–65 - NCT06835387RecruitingPhase 2
Combination Chemotherapy for Advanced Small Bowel Cancer
This trial tests a combination of chemotherapy drugs (NALIRIFOX) for people with advanced small bowel adenocarcinoma that cannot be surgically removed. It is for those who have not yet had treatment for their advanced cancer, except possibly one cycle of FOLFOX.
Tampa, FloridaAges 18 years+ - NCT06476145Recruiting
Testing two ways to reduce polyp regrowth after removal
This study looks at two different methods for removing large colon polyps to see which one better prevents polyps from coming back. It may help people who have a non-cancerous, flat polyp that is at least 20 mm wide.
Orlando, FloridaAges 18 years+ - NCT06533592Recruiting
Bile duct connection technique in liver transplant
This study compares two ways of connecting the bile duct during a liver transplant to see which leads to a smoother recovery. It is for adults having a planned first transplant from a deceased donor.
Warsaw, Masovian VoivodeshipAges 18–75 - NCT07127354RecruitingPhase 4
GLP-1 medications and colonoscopy prep quality
This study tests whether a special bowel preparation plan works better for people taking GLP-1 or GIP medications (like Ozempic, Mounjaro) before a colonoscopy. It aims to improve the quality of the bowel cleaning so doctors can see the colon more clearly.
Cleveland, FloridaAges 18 years+ - NCT07437911Recruiting
Can a Supplement Help with Nutrient Gaps for GLP-1 Users?
This study tests whether a daily supplement can help fill nutrient gaps and improve gut health for people who are already taking GLP-1 weight-loss medications (like Ozempic or Wegovy). Participants must be on a stable dose for at least 8 weeks and be generally healthy without other chronic conditions.
Santa Monica, CaliforniaAges 18–59 - NCT06474403Recruiting
Laparoscopic repair for stoma-related hernias
This study tests a specific laparoscopic (keyhole) surgery to fix parastomal hernias — a bulge near your stoma. The goal is to repair the hernia safely and help you avoid more problems with your stoma pouch.
KrasnodarAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.