Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT07431723Recruiting
Magnetic magnets to connect the intestines during surgery
This trial is testing a new way to connect parts of the large or small intestine using magnets instead of staples or stitches. It may help people who need certain types of colon or rectal surgery recover with less pain and fewer complications.
SantiagoAges 18–75 - NCT06434597RecruitingPhase 2
Study of SPH5030 for HER2-positive advanced colorectal or bile duct cancer
This study tests a new medication (SPH5030) for people with advanced colorectal or biliary tract cancer whose tumors have a specific marker called HER2. It may offer a treatment option if previous therapies have stopped working.
BeijingAges 18 years+ - NCT06339671Recruiting
Recovery after surgery: smoking and complications
This study looks at how smoking habits affect recovery after colorectal surgery. It aims to understand if smokers have more complications than non-smokers, which could help tailor care before and after surgery.
MilanAges 18 years+ - NCT06356558Recruiting
Making recovery programs easier for patients with limited health literacy
This study is testing ways to improve recovery programs for patients who may have trouble understanding health information. It aims to make these programs easier to follow, so patients can have better recovery after surgery.
Birmingham, AlabamaAges 18 years+ - NCT07421596Recruiting
Dietary supplement study for gut and digestive health
This trial tests whether a dietary supplement system can improve gut and digestive health over 8 weeks. You may be eligible if you have digestive symptoms like bloating, stomach pain, or diarrhea.
San Francisco, CaliforniaAges 18–80 - NCT06329973RecruitingPhase 1/Phase 2
Fruquintinib, sintilimab, and chemo for stomach cancer
This trial tests a combination of three drugs (fruquintinib, sintilimab, and CAPEOX chemotherapy) as a first treatment for advanced stomach or gastroesophageal cancer. The goal is to see if this combination helps slow or shrink the tumor.
Zhengzhou, HenanAges 18–75 - NCT03566797Recruiting
Study in ICU patients with prolonged breathing support
This study looks at outcomes in adults who need breathing support for at least 5 days in intensive care. It may help clinicians better understand and manage complications in this critical illness group.
GrazAges 18 years+ - NCT06357897Recruiting
New PEG formula for children with functional constipation
This trial tests a new, better-tasting liquid formula (PEG-based) for children with functional constipation. It aims to see if it works as well as or better than current treatments and if children like the taste more.
BangkokAges 6 months–18 years - NCT06894797Recruiting
Chemo and radiation before and after surgery for rectal cancer
This study tests a sequence of chemotherapy and radiation before and after surgery for rectal cancer. It compares giving more chemo between the end of radiation and surgery (consolidation) versus giving some chemo before radiation starts (induction). The goal is to see which order works better.
BeijingAges 18–75 - NCT06422052Recruiting
H. pylori infection and its treatment for stomach discomfort
This trial is for adults aged 18 to 80 who have a Helicobacter pylori (H. pylori) infection in their stomach and have never been treated for it. The study will look at how treating the infection affects symptoms like indigestion or stomach pain.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT07648446Recruiting
Learning About Pulses and Gut Health in Children
This study teaches children ages 6–13 about pulses (beans, lentils, chickpeas) and how they affect gut health. Researchers want to understand whether eating pulses helps children's digestive systems work better.
Tallahassee, FloridaAges 6–13 - NCT06324396RecruitingPhase 1
Improving drug dosing for single ventricle patients with liver disease
This trial studies how the drugs sildenafil and pravastatin work in people with a single ventricle heart condition who have had the Fontan surgery and may have related liver problems. The goal is to find the best doses based on liver function.
Kansas City, MissouriAges 8 years+ - NCT06327308RecruitingPhase 1
MRI study for heart health in liver transplant candidates
This study uses a special heart MRI to check for a heart condition called cirrhotic cardiomyopathy in people waiting for a liver transplant. The results may help doctors better understand and treat heart problems in patients with cirrhosis.
BesançonAges 18–70 - NCT06341335RecruitingPhase 3
AK104 and AK109 plus paclitaxel for advanced stomach cancer
This trial tests a combination of two experimental immunotherapies (AK104 and AK109) with a standard chemo drug (paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has grown after initial treatment. The goal is to see if this new combination can help shrink tumors or slow the cancer better than chemo alone.
BeijingAges 18–75 - NCT07698158Recruiting
Growing Well Study: healthy growth study for young children
This study looks at how children aged 6 months to 4 years grow and develop. It involves families in Leeds, Doncaster, or East London. Researchers want to understand what supports healthy growth in early childhood.
Doncaster, West YorkshireAges 6 months–4 years - NCT07699809Recruiting
Thirst relief kit for thirst after colonoscopy prep
This trial tests whether a 'thirst relief kit' can help reduce thirst after the bowel preparation for a colonoscopy. If you are having a colonoscopy with hospital-based bowel preparation, you may be eligible to receive the kit or a placebo (a kit without active ingredients) to see if it helps with thirst.
São Paulo, São PauloAges 18 years+ - NCT01212250Recruiting
Carvedilol to prevent esophagus bleeding in cirrhosis
This trial tests whether carvedilol can prevent the first development of swollen veins (varices) in the esophagus in people with cirrhosis who do not have them yet. It may help lower the risk of future bleeding from those veins.
New Delhi, National Capital Territory of DelhiAges 18–75 - NCT06861452RecruitingPhase 1/Phase 2
Testing a new drug after chemo for advanced pancreatic cancer
This study tests an investigational drug (RR001) given after chemotherapy for people with locally advanced pancreatic cancer that hasn't spread. It aims to see if the new treatment is safe and may help shrink tumors that can be reached with a needle injection.
Modena, ItalyAges 18 years+ - NCT06861075Recruiting
Carvedilol for high blood pressure in liver veins
This trial tests whether a medicine called carvedilol can lower high blood pressure in the liver veins of people with cirrhosis. It uses a special ultrasound probe to measure the pressure before and after taking the medicine.
Clermont-FerrandAges 18 years+ - NCT07147101Recruiting
Immunotherapy for advanced liver cancer: a study on effectiveness and immune response
This study looks at different first-line immunotherapy treatments for people with advanced liver cancer that cannot be treated with surgery or local therapies. It aims to understand how well these treatments work and how they affect the body's immune system.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06740799RecruitingPhase 1
Quizartinib study for people with severe liver problems
This trial tests how the body processes quizartinib when the liver is severely impaired. It helps doctors understand if the dose needs to be adjusted for patients with liver issues.
Miami, FloridaAges 18–75 - NCT07634549RecruitingPhase 4
Plant-based albumin for low blood protein after liver surgery
This trial tests a new protein treatment made from rice to help patients recover from low blood protein levels that sometimes occur after liver surgery. The treatment may help your body heal better after the procedure.
Wuhan, HubeiAges 18–80 - NCT06841679RecruitingPhase 2/Phase 3
Testing utidelone plus chemo for untreated stomach cancer
This trial tests a new capsule (utidelone) combined with standard chemotherapy as a first treatment for advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. It aims to see if this combination works better than current options.
Hialeah, FloridaAges 18 years+ - NCT07627347Recruiting
Anlotinib and Bemocizumab for Early Esophageal Cancer
This study tests two drugs (anlotinib and bemocizumab) given before surgery to shrink esophageal squamous cell carcinoma (a type of throat cancer). The goal is to see if this combination helps patients have better outcomes and fewer side effects.
Guangzhou, GuangdongAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.