Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT04520737Recruiting
Exercise coaching during chemotherapy for liver metastases
This trial studies whether a “prehab” program—structured exercise and preparation—can help people keep up function while they are on chemotherapy for colorectal cancer that has spread to the liver. If you can safely exercise, the program may help you tolerate treatment and stay active.
TarragonaAges 18 years+ - NCT06481072Recruiting
Digital therapy for kids with chronic stomach pain
This trial tests a digital (online) therapy program to help children with chronic stomach pain. It's designed for kids ages 8 to 14 who have been diagnosed with a functional abdominal pain disorder and can use a computer or tablet at home.
GothenburgAges 8–14 - NCT06385730RecruitingPhase 2
PD-1 blocker before surgery for elderly esophageal cancer
This trial tests a drug (PD-1 blocker) given before surgery for people over 75 with esophageal cancer. The goal is to see if it helps shrink the tumor and improve outcomes.
Shanghai, Shanghai MunicipalityAges 76 years+ - NCT06482788RecruitingPhase 2
Immunotherapy plus chemo before & after junction cancer surgery
This trial tests giving an immunotherapy drug (adebrelimab) along with two chemotherapy drugs (capecitabine and oxaliplatin) before and after surgery for a specific type of stomach-cancer junction tumor. It aims to see if this combination is safe and effective in shrinking the tumor and improving outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06485271Recruiting
Camrelizumab for advanced gastric cancer
This trial tests a drug called camrelizumab, alone or with other treatments, for people with advanced stomach cancer that has worsened or returned. It aims to see how well this treatment works in real-world patients.
Changzhi, ShanxiAges 18–75 - NCT06482801RecruitingPhase 2
Immunotherapy combo for newly treated liver cancer
This trial tests a combination of immunotherapy drugs given directly into the liver’s blood supply as a first treatment for liver cancer. It aims to see if this approach can shrink tumors and improve outcomes for people with relatively preserved liver function.
GuangzhouAges 18–75 - NCT06339060RecruitingPhase 3
Chemoradiation and immunotherapy to save the esophagus
This trial tests whether adding immunotherapy to standard chemoradiation (chemotherapy plus radiation) can help preserve the esophagus and avoid surgery in people with resectable esophageal cancer. It aims to see if this combination is safer and more effective than current treatment.
ShanghaiAges 18–75 - NCT06466902Recruiting
Using photos to check lymph node removal in stomach cancer surgery
This study tests if taking photos during minimally invasive stomach cancer surgery can help doctors check that all the right lymph nodes were removed. If you're having a laparoscopic or robotic gastrectomy for stomach cancer, this study might be for you.
Cremona, CRAges 18 years+ - NCT06487663Recruiting
TACE plus immunotherapy for untreated liver cancer
This study tests combining TACE (a procedure to block the tumor's blood supply) with immunotherapy drugs for liver cancer that has not spread outside the liver. It is for people who have not had any prior treatment for their liver cancer and are healthy enough for TACE.
TianjinAges 18–75 - NCT06267378Recruiting
Frailty and its effects on older patients having major gut surgery
This study looks at how frailty affects recovery and outcomes for patients aged 70 and older who are having planned surgery to remove colorectal cancer. The goal is to better understand frailty's impact so care can be improved.
Doncaster, South YorkshireAges 18 years+ - NCT06313567RecruitingPhase 3
Metronomic capecitabine for stage III stomach cancer
This trial tests a low-dose, frequent regimen of the chemotherapy drug capecitabine (taken as a pill) to see if it can help prevent stage III stomach cancer from coming back after surgery. It's for people who have had their stomach cancer completely removed with a specific type of lymph node dissection.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06487429RecruitingPhase 2
Short radiation followed by combo therapy for HER2+ stomach cancer
This trial tests a new approach for stomach cancer that has spread to nearby tissues but not to other organs. You would get a short course of radiation, followed by a combination of targeted therapy (Disitamab Vedotin), chemotherapy (S-1), and immunotherapy (Sintilimab) before surgery to shrink the tumor and improve outcomes.
Wuhan, HubeiAges 18–75 - NCT07814976Recruiting
Medication during balloon dilation for bile duct stones
This trial tests whether giving a medication called hyoscine butylbromide (which relaxes the muscles around the bile duct) during a balloon dilation procedure makes it easier to remove bile duct stones. If you are eligible, this may improve the success of the procedure and reduce the need for more invasive treatments.
RigaAges 18 years+ - NCT07815392Recruiting
Frailty and recovery after gastrointestinal cancer surgery
This study looks at how frailty, or overall physical weakness, affects recovery after surgery for gastrointestinal cancer in people aged 60 and older. The findings may help doctors better prepare patients for surgery and improve their recovery.
Van, VanAges 60 years+ - NCT07812805RecruitingPhase 1
New targeted treatment with imaging for advanced solid tumors
This trial tests a new experimental treatment (SKL35501) that uses a special imaging agent (SKL35502) to find and target a marker called NTSR1 found on some advanced cancers. The goal is to see if this treatment is safe and can help people whose cancer has stopped responding to standard treatments.
Glen Burnie, MarylandAges 18 years+ - NCT07811193RecruitingPhase 2
Study of new drug combined with immunotherapy for advanced bowel cancer
This trial tests a new drug (VVD-133214) combined with an existing immunotherapy (pembrolizumab) for advanced colorectal cancer that is mismatch repair deficient. It aims to see if the combination works better than pembrolizumab alone in shrinking or controlling the cancer.
Tucson, ArizonaAges 18 years+ - NCT07814248RecruitingPhase 1
TS-104 for advanced solid tumors
This trial tests a new drug called TS-104 for people with certain advanced solid tumors that have stopped responding to standard treatments. The drug is given alone (not with other cancer treatments) to see if it can shrink tumors or slow their growth.
Maumee, OhioAges 18 years+ - NCT06124456Recruiting
Vigorous vs. moderate exercise for liver fat reduction
This study compares high-intensity exercise to moderate-intensity exercise to see which is better at reducing fat in the liver for people with obesity and fatty liver disease.
Hong KongAges 18–69 - NCT05462236RecruitingPhase 2
Study drug AUM001 with immunotherapy or chemotherapy for metastatic colon cancer
This Phase 2 trial tests AUM001 (a targeted drug) combined with either pembrolizumab (an immunotherapy) or irinotecan (a chemotherapy) in people with metastatic colorectal cancer. It aims to shrink tumors and improve outcomes when standard treatments have already been tried.
Camperdown, New South WalesAges 18 years+ - NCT06492408RecruitingPhase 2
Immunotherapy before surgery for liver cancer
This trial tests giving two immunotherapy drugs directly into the tumor before surgery for liver cancer. It aims to see if this approach can shrink the tumor and improve outcomes for patients who are candidates for surgery.
Guanzhou, GuangdongAges 18–75 - NCT06491472RecruitingPhase 2
Ivonescimab with radiation and chemo for pancreatic cancer
This trial tests a new immunotherapy drug (ivonescimab) combined with targeted radiation and chemotherapy for people with pancreatic cancer. The goal is to see if this combination can shrink tumors and improve outcomes.
WuhanAges 18 years+ - NCT07810374Enrolling by invitation
Learning program for swallowing difficulties after stroke
This trial tests an interactive teaching system that helps stroke patients learn about swallowing difficulties (dysphagia). The program uses videos and quizzes to teach you techniques to swallow safely, which might help you recover and avoid complications.
Yuli, Yilan CountyAges 20–75 - NCT07814014Recruiting
Systemic therapy options for liver cancer
This trial studies which systemic treatments (medicines that travel through the blood to reach cancer cells) work best for patients with advanced liver cancer. It aims to find the most effective approach to slow tumor growth and improve quality of life.
Al Mansurah, Dakahlia GovernorateAges 18 years+ - NCT07811687Recruiting
Liver and spleen surgery for liver cancer with cirrhosis
This study tests whether removing part of the liver along with the spleen during laparoscopic (keyhole) surgery helps improve liver function and the immune system in people with liver cancer and cirrhosis. If you qualify, you may have better surgical outcomes and recovery.
Yangzhou, JiangsuAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.