Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT03741777Recruiting
Comparing stomach fluid left after different clear drinks in kids
This study looks at how much clear liquid is left in the stomach after children drink different measured amounts before an endoscopy. The goal is to help make anesthesia and endoscopy safer by better understanding stomach “residual volume.”
Boston, MassachusettsAges 13–17 - NCT03746210Recruiting
Testing a painless scan to study liver spots in cirrhosis
This trial studies “focal liver lesions,” meaning specific spots in the liver, using a non-invasive (no surgery or biopsy) approach. It may help doctors better understand what these spots are in people who have cirrhosis.
BonnAges 18–99 - NCT06361498Recruiting
Ultrasound to check G-tube position in children
This study tests if ultrasound can quickly and safely check the position of a G-tube (feeding tube) that has moved or come out. It looks for a possible alternative to X-rays for children.
Chapel Hill, North CarolinaAges Up to 18 years - NCT06168292Recruiting
Combined treatment for bile duct cancer
This trial is testing a new approach for people with bile duct cancer that cannot be removed by surgery. It combines a procedure that uses heat to destroy cancer cells inside the bile duct with standard radiation therapy.
Goyang-si, OtherAges 20 years+ - NCT07150546RecruitingPhase 1
Radiation and Peptide Therapy for Large Gut Neuroendocrine Tumors
This trial combines external radiation with a targeted radioactive drug (PRRT) to treat large, slow-growing neuroendocrine tumors in the gut that have spread and are not removable by surgery. It aims to see if this combination works better than either treatment alone.
Atlanta, GeorgiaAges 18 years+ - NCT06133062RecruitingPhase 2
Study of atezolizumab, bevacizumab, and proton therapy for advanced liver cancer
This trial tests a combination of two immunotherapy drugs (atezolizumab and bevacizumab) plus targeted proton radiation for liver cancer that cannot be removed by surgery. The goal is to see if this approach can shrink tumors and improve outcomes for people with intermediate or advanced stage liver cancer.
Taoyuan City, TaiwanAges 18 years+ - NCT07133620Recruiting
Electrical acupoint stimulation for better recovery after urologic surgery
This trial tests if using mild electrical stimulation on specific acupoints (similar to acupuncture without needles) can help your stomach and bowels get back to normal faster after laparoscopic kidney or prostate surgery.
Xiamen, FujianAges 18 years+ - NCT06075745RecruitingPhase 2
CMV Vaccine Study for Liver Transplant Candidates
This trial tests a vaccine to prevent cytomegalovirus (CMV) infection in people awaiting a first liver transplant. You may be eligible if you have never been infected with CMV and are scheduled to receive a liver transplant within the next 1 to 12 months.
Birmingham, AlabamaAges 18 years+ - NCT07120906Recruiting
Augmented reality guidance for MRI liver procedures
This study tests a new augmented reality system to help doctors place needles in the liver during MRI scans for biopsies or ablation (heat to destroy tumors). The goal is to see if it improves accuracy and speed.
Jacksonville, FloridaAges 18–90 - NCT03225677Recruiting
Testing a new scan to study muscle breakdown in cirrhosis
This study looks at how your body uses protein in your muscles when you have cirrhosis (a scarred liver). It uses a special “tracer” method (a substance that can be tracked) and may help researchers better understand muscle loss in people with milder cirrhosis.
Cleveland, OhioAges 18 years+ - NCT07114055RecruitingPhase 2/Phase 3
Ebastine for diarrhea-predominant IBS
This trial tests whether ebastine, an allergy medicine, can help relieve symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D). If you have IBS-D and are at least 18, this study may offer a new option to manage your condition.
DhakaAges 18 years+ - NCT03471793Recruiting
Test for removing large, flat colon growths by endoscopy
This study looks at patients who have a large, flat (sessile) or spreading growth in the colon that doctors plan to remove using an endoscopy. It aims to study the endoscopic removal process and outcomes for these bigger lesions.
Westmead, New South WalesAges 18–99 - NCT06051851RecruitingPhase 2
Study of penpulimab, anlotinib, and chemo for advanced pancreatic cancer
This trial tests a combination of immunotherapy (penpulimab), a targeted therapy (anlotinib), and two chemotherapy drugs (nab-paclitaxel and gemcitabine) as a first treatment for pancreatic cancer that has spread. It aims to see if this new combination works better than standard care.
Nanjing, JiangsuAges 18 years+ - NCT01822470Enrolling by invitation
Registry studying bacteria patterns in suspected small bowel overgrowth
This is a research registry that collects small-bowel fluid samples from people being tested for “SIBO” (an overgrowth of bacteria in the small intestine). It aims to describe what bacteria are present and how results differ between people with suspected SIBO and others having similar tests for other reasons.
Indianapolis, IndianaAges 18–90 - NCT07118527RecruitingPhase 3
New drug combo for untreated advanced stomach cancer
This trial tests a new combination of an anti-HER2 drug (SHR-A1811) plus chemotherapy and an immunotherapy (adebrelimab) for people with untreated advanced stomach cancer. It aims to see if this combination works better than standard treatment.
Shenyang, LiaoningAges 18–75 - NCT01033838RecruitingPhase 2
Two minimally invasive surgery options for recurrent diverticular problems
This trial compares two types of minimally invasive surgery for people with recurrent diverticular disease who need surgery for a benign (non-cancerous) polyp and have an early, limited tumor in the sigmoid colon/rectosigmoid area. It may help find which approach is safer or better for recovery.
LeuvenAges 18–90 - NCT03518099Recruiting
Testing blood signals after sudden bowel blood flow injury
This study is looking for signs in the body (called biomarkers) after sudden loss of blood flow to the intestines. It involves getting a CT scan to check what is happening in the abdomen so the researchers can see which signals match intestinal injury.
ClichyAges 18 years+ - NCT03121404Recruiting
Study causes of poor nutrition in people with liver scarring
This study looks at why some people with cirrhosis (liver scarring) develop malnutrition, especially when blood flow is redirected during certain surgeries. It may help explain what contributes to low body weight and muscle so better treatments can be planned in the future.
Cleveland, OhioAges 18–70 - NCT07159022Recruiting
High-flow nasal oxygen vs mask for people with belly fat having sedated stomach scope
This study compares two ways of giving oxygen during a sedated gastroscopy for people with visceral obesity (extra belly fat). One method uses a high-flow nasal cannula, the other a face mask. The goal is to see which keeps oxygen levels more stable.
ShanghaiAges 18–80 - NCT03488953Recruiting
Two-step liver surgery using a living donor transplant
This study looks at a specialized liver transplant approach using a living donor, for people with colorectal cancer that has spread only to the liver and cannot be removed by standard surgery. It’s meant for cases where chemotherapy has helped stop or shrink the tumors, to improve the chance of successful treatment.
JenaAges 18 years+ - NCT03713879RecruitingPhase 3
Indomethacin vs pancreatic stent to prevent post-ERCP pancreatitis
This study compares indomethacin (an anti-inflammatory medicine) against using a temporary pancreatic stent to prevent pancreatitis after an ERCP procedure. It may help you lower the chance of painful inflammation of the pancreas after ERCP.
Xi'an, ShaanxiAges 18–99 - NCT06767007RecruitingPhase 2
Radiation plus immunotherapy for recurrent rectal cancer
This trial studies a combination of SBRT (a precise kind of radiation) and an immunotherapy drug (PD-1 antibody) for people whose rectal cancer has come back in the pelvis and cannot be removed by surgery. The goal is to see if this treatment can shrink the tumor or stop it from growing.
Guangzhou, GuangdongAges 18–75 - NCT07178340RecruitingPhase 2
Perioperative therapy for HER2-negative stomach cancer
This trial tests a treatment given before and after surgery for a rare type of stomach cancer called hepatoid adenocarcinoma. It aims to improve outcomes for patients whose tumors are HER2-negative and have not spread too far.
BeijingAges 18–75 - NCT07656181Recruiting
Standardizing quality criteria for liver ultrasound with contrast
This trial gathers expert doctors to create standard quality rules for liver ultrasound exams that use contrast dye. If you're a very experienced ultrasound doctor, your opinion could help shape future care.
Bern, Canton of BernAges Any age
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.