Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT06944795Recruiting
SWIR otoscopy for children getting ear tubes
This study uses a special type of otoscope (ear camera) to look inside the ears of children getting ear tubes. It will help doctors see if this new tool gives better images of the middle ear.
Palo Alto, CaliforniaAges 1–17 - NCT07431125Recruiting
Surgery and hearing test link in one-sided conductive hearing loss
This study looks at how surgery findings relate to hearing tests in people with one-sided conductive hearing loss but a normal eardrum. It may help if you have a specific type of hearing loss where sound is blocked, and your eardrum is intact.
Asyut, Asyut GovernorateAges Any age - NCT06729632Recruiting
Cooling device to protect ears from noise damage
This trial tests a non-invasive device that cools the ears to prevent hearing loss from loud noise. It is for adults aged 18-55 with normal hearing who are at risk for noise-induced hearing loss, such as firefighters.
Miami, FloridaAges 18–55 - NCT06375278Recruiting
Cooling device to protect hearing during cochlear implant
This trial tests a special cooling device used during cochlear implant surgery to help protect any remaining hearing you have. It may be a good option if you are already planning to get a cochlear implant at the University of Miami.
Miami, FloridaAges 18 years+ - NCT06475300RecruitingPhase 2
BL-B01D1 plus immunotherapy for advanced lung and throat cancers
This trial tests a new combination treatment (BL-B01D1 plus a PD-1 inhibitor) for people with advanced lung cancer or nasopharyngeal cancer. It aims to see if the combination is safe and effective for patients whose cancer has not responded to earlier treatments.
Guangzhou, GuangdongAges 18 years+ - NCT07718620Recruiting
HPV-related throat cancer radiation trial
This trial tests whether radiation or chemoradiation works well for HPV-positive throat cancer. It may be an option if you have this type of cancer and are getting or have already had surgery.
Brno, Czech RepublicAges 18 years+ - NCT06634823RecruitingEarly Phase 1
Steroid injection for chronic cough study
This study tests whether a steroid shot into the neck muscles can help people with a long-lasting, unexplained cough. It is for adults who have tried other treatments and still cough.
Charleston, South CarolinaAges 18 years+ - NCT04899037Recruiting
Long-term follow-up for people using an implanted hearing device
This study checks how well long-term care works for people who may use an osseointegrated hearing device (an implanted option that connects to bone). It may help by improving long-term support and outcomes for hearing and day-to-day functioning over about three years.
Tampa, FloridaAges 18–85 - NCT06824649RecruitingPhase 4
Comparing biologics for chronic sinusitis with nasal polyps
This trial compares three different biologic medications (injectable drugs) to see which one works best for people with chronic sinusitis and nasal polyps. If you have moderate to severe symptoms and are considering biologic therapy, this study might help find the best option for you.
Portland, OregonAges 18 years+ - NCT07625657Recruiting
CLIKX System for Ear Tube Placement Surgery
This trial tests a new device called CLIKX that helps doctors place small tubes in the eardrum to treat ear fluid and hearing problems. The study will evaluate whether this device works safely and effectively for patients needing ear tube surgery.
Louisville, KentuckyAges 6 months+ - NCT05492266Recruiting
Breathing muscle training for nasal speech in children
This trial tests whether strengthening the muscles you use to breathe out can help children ages 5–17 who have too much nasal sound in their speech. If it works, it could reduce the need for surgery.
Pittsburgh, PennsylvaniaAges 5–17 - NCT07714525RecruitingPhase 2
Steroid nanocapsules after nasal surgery
This trial tests whether a new form of steroid (triamcinolone) delivered in tiny capsules can improve healing after common nasal surgeries for chronic sinusitis or nasal polyps.
Minya, Menia GovernorateAges 18–60 - NCT05172245RecruitingPhase 1
Testing a new drug added to chemoradiation for head and neck cancer
This study tests whether adding a new targeted drug called ipatasertib to standard chemoradiation can improve treatment for people with locally advanced head and neck cancer. Ipatasertib may help block a protein that helps cancer grow, possibly making the standard therapy more effective.
Tampa, FloridaAges 18 years+ - NCT07711639Recruiting
Tinnitus treatment with nerve stimulation
This trial tests a non-invasive treatment that stimulates a nerve in your ear or foot (called taVNS) to see if it helps reduce tinnitus. It is for people whose main problem is tinnitus and who have normal hearing in both ears.
Hualien CityAges 18–75 - NCT06070376Recruiting
Comparing two stents for esophageal cancer swallowing problems
This study compares two types of stents (metal tubes) placed in the esophagus to help people with advanced esophageal cancer swallow more easily. Both stents are designed to keep the esophagus open and improve quality of life.
São Paulo, São PauloAges 18 years+ - NCT06788990RecruitingPhase 2/Phase 3
Study of ficerafusp alfa with pembrolizumab for advanced head and neck cancer
This study tests a new drug called ficerafusp alfa (BCA101) combined with the immunotherapy pembrolizumab for people with advanced head and neck cancer that has not been treated before. The goal is to see if adding ficerafusp alfa helps shrink tumors better than pembrolizumab alone.
Birmingham, AlabamaAges 18 years+ - NCT07706985RecruitingPhase 3
Immunotherapy for advanced nasopharyngeal cancer
This trial tests a new combination of chemotherapy and immunotherapy drugs for advanced nasopharyngeal cancer that has not spread to distant parts of the body. The goal is to see if this approach works better than standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT07709143Recruiting
MRI study of balance disorders in older adults
This study uses MRI scans to look at the brain and inner ear in people with balance problems called bilateral vestibulopathy and presbyvestibulopathy. It aims to understand risk factors and improve diagnosis.
Shanghai, Shanghai MunicipalityAges 16 years+ - NCT06662058Recruiting
Remote hearing test for head and neck cancer patients on cisplatin or radiation
This study tests a remote hearing test to monitor hearing changes in patients with head and neck cancer getting cisplatin chemotherapy and/or radiation. The goal is to catch hearing loss early so treatment can be adjusted.
Atlanta, GeorgiaAges 18 years+ - NCT07708467Enrolling by invitation
Esophageal function study in eosinophilic esophagitis
This study looks at how the esophagus stretches and moves in people with eosinophilic esophagitis (EoE) who still have symptoms even though their inflammation is under control. The goal is to better understand why symptoms persist and find better ways to measure them.
Milan, MIAges 18 years+ - NCT05799144RecruitingPhase 2
Pembrolizumab plus investigational HPV drugs for throat cancer
This Phase 2 trial studies pembrolizumab (an immune therapy) combined with investigational treatment(s) pBI-11 and TA-HPV for advanced or recurrent oropharyngeal cancer that is HPV-positive and has certain immune marker levels (PD-L1 CPS ≥ 1). It may help your immune system better attack cancer.
Birmingham, AlabamaAges 18 years+ - NCT02960737Recruiting
Training for swallowing problems after stroke
This trial studies whether a specific oral training program can improve swallowing after a stroke. It’s mainly for people whose swallowing trouble has lasted for several weeks after their stroke.
UmeåAges 18 years+ - NCT02975310Recruiting
In-clinic endoscopy surgery for chronic sinus polyps
This trial tests an in-clinic (not hospital) endoscopic procedure to remove nasal polyps in people with chronic sinus inflammation, after usual medicines haven’t helped. It may help reduce nasal blockage and improve sinus symptoms, while comparing safety and outcomes after the procedure.
Vancouver, British ColumbiaAges 18 years+ - NCT03042962Recruiting
Brain imaging study of focal dystonia and related conditions
This trial uses brain scans to understand how brain networks work in people with focal dystonia, and to compare with family members and healthy volunteers. It may help researchers better understand what goes wrong in the brain and guide future treatments.
Boston, MassachusettsAges 21–80
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.