Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,228 recruiting studies in this area right now.
By phase
- Not applicable3,145
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,228 total
- NCT06082284Recruiting
M protein detection study for adult patients
This study is looking for adults at Zhujiang Hospital to test a new, highly sensitive method for detecting a protein called M protein in the blood. It helps doctors understand how common this protein is in different patients.
Guangzhou, GuangdongAges 18 years+ - NCT06082063RecruitingPhase 3
Reducing heart disease risk in type 1 diabetes
This trial tests a combination of treatments to lower the risk of heart disease and kidney problems in people with type 1 diabetes who already have some complications or higher risk. If you qualify, you will receive extra care aimed at preventing heart attacks, strokes, and kidney failure.
CopenhagenAges 40–90 - NCT06083207RecruitingPhase 1/Phase 2
IBI3003 for multiple myeloma that has returned or not responded
This trial tests an investigational drug called IBI3003 in people with multiple myeloma that has come back or hasn't responded to previous treatments. The goal is to see if it is safe and effective.
Wollongong, New South WalesAges 18 years+ - NCT06083922RecruitingPhase 2
CyBorD plus Daratumumab for kidney disease caused by abnormal proteins
This trial tests a combination of four drugs (CyBorD plus daratumumab) to treat kidney damage caused by abnormal proteins (monoclonal gammopathy). It aims to improve kidney function and reduce protein levels.
Boston, MassachusettsAges 18 years+ - NCT06084962RecruitingPhase 1
GPRC5D-targeted CAR-T cells for advanced multiple myeloma
This trial tests a new type of CAR-T cell therapy that targets a protein called GPRC5D on multiple myeloma cells. It is for people whose myeloma has not responded to or has returned after at least three prior treatments, and aims to see if this targeted approach can help control the disease.
Hangzhou, ZhejiangAges 18–75 - NCT06085118Recruiting
Observatory on cow's milk protein allergy in babies
This study is watching babies with a cow's milk protein allergy who are given a special formula called Pepticate® Syneo®. It helps doctors learn how babies do on this formula over time.
NiceAges Up to 8 months - NCT06088277Recruiting
Texting to reduce HIV risk for dental patients
This study tests if daily text messages can help people lower their risk of getting HIV. You'll receive texts for a few months and complete surveys to see if the messages help.
Boston, MassachusettsAges 18 years+ - NCT06091254RecruitingPhase 3
Comparing odronextamab to standard chemo for untreated follicular lymphoma
This trial tests if a new drug called odronextamab is safe and works as well as a common antibody (rituximab) plus chemotherapy for people with a type of slow-growing lymphoma that hasn't been treated yet. It's for adults with grade 1-3a follicular lymphoma that is bulky stage II or stage III/IV.
Tucson, ArizonaAges 18 years+ - NCT06092346Recruiting
Understanding rare purine and pyrimidine metabolism disorders
This study aims to learn more about rare disorders of purine and pyrimidine metabolism (DPPM), which can affect the brain, immune system, kidneys, and muscles. Researchers will study people with these disorders, their family members, and healthy volunteers to better understand the condition over time.
Bethesda, MarylandAges 1 month–100 years - NCT06092528Recruiting
Pulmonary rehab for kids with primary immunodeficiency
This study tests whether a pulmonary rehabilitation program helps children aged 6–18 with primary immunodeficiency improve their breathing and physical fitness. If your child has this condition and is not currently having a lung infection or other serious health issues, they may be able to join.
Ankara, ÇankayaAges 6–18 - NCT06093204Recruiting
Ultra-processed foods and eosinophilic esophagitis study
This study looks at how certain chemicals from ultra-processed foods (like packaged snacks and sodas) might trigger eosinophilic esophagitis, a food allergy condition. It will compare people with the disease to healthy volunteers of the same age and sex.
NaplesAges 3–65 - NCT06094881RecruitingPhase 2
Obinutuzumab for teens with immune thrombocytopenia
This trial tests a drug called obinutuzumab for teens aged 12–18 with persistent or chronic immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The study aims to see if obinutuzumab can safely raise platelet counts in those who haven't responded well to steroids or other treatments.
TianjinAges 12–18 - NCT06094855Recruiting
Cooling and balance in multiple sclerosis
This trial tests if cooling therapy can improve balance in people with multiple sclerosis. If you can stand without help for at least one minute, you may qualify.
New York, New YorkAges 18–75 - NCT06096272Recruiting
Using augmented reality to help kids with cerebral palsy be more active
This trial tests if using an augmented reality game on a tablet can help children with cerebral palsy walk and move more each day. It could be an option if your child can walk on their own and doesn't have upcoming leg surgery.
Los Angeles, CaliforniaAges 5–18 - NCT06096857RecruitingPhase 2
Cardamom and topical bacteria cream for eczema
This study tests whether taking cardamom by mouth and applying a cream made from a harmless bacteria (Roseomonas) can help treat eczema (atopic dermatitis) in people age 2 and older.
Bethesda, MarylandAges 2–100 - NCT06098430Recruiting
Quality of life in NLPHL patients
This study looks at how people with a rare type of Hodgkin lymphoma (NLPHL) feel about their health and quality of life. By filling out surveys, you can help doctors understand what really matters to patients like you.
Palo Alto, CaliforniaAges 8 years+ - NCT06100211Recruiting
HIV, gut health, and switching HIV meds study
This study looks at how changing your HIV medication affects the bacteria in your gut. You'll provide two stool samples so researchers can see what changes happen.
Manchester, Greater ManchesterAges 18 years+ - NCT06100237RecruitingPhase 2
Teclistamab and daratumumab for high-risk smoldering myeloma
This trial tests two immunotherapy drugs (teclistamab and daratumumab) for people with high-risk smoldering myeloma to see if the combination can stop or delay progression to active multiple myeloma. It's a new approach for those whose smoldering myeloma has a higher chance of becoming active.
Miami, FloridaAges 18 years+ - NCT06099912Recruiting
Personalized frailty-based treatment for older adults with new multiple myeloma
This trial tests a personalized treatment approach for people aged 65 and older with newly diagnosed multiple myeloma. The goal is to tailor therapy based on each patient's level of frailty, which could help improve outcomes and reduce side effects.
Changchun, JilinAges 65 years+ - NCT06101381RecruitingPhase 1/Phase 2
Car-T cell therapy for relapsed or refractory leukemia and lymphoma
This trial tests whether a new immune therapy (CAR-T cells) can treat certain types of blood cancers that have come back or not responded to standard treatments. It aims to help people with aggressive B-cell lymphoma or acute lymphoblastic leukemia (ALL) that hasn't been controlled by other therapies.
Campinas, São PauloAges 3–70 - NCT06102330Recruiting
Helping parents decide about home breathing machines
This study helps parents like you who are deciding whether their child should have a breathing machine at home. You'll use a website or get support by phone to learn about your options and share what matters most to your family, so doctors and families can make better choices together.
Tampa, FloridaAges 18 years+ - NCT06103370Recruiting
HIV prevention via telemedicine and peer networks
This study tests how well a program combining telemedicine (virtual doctor visits) and peer support can help prevent HIV among people who inject drugs. You'd get trained, attend weekly group sessions, and invite a friend or partner to also take part.
Baltimore, MarylandAges 18 years+ - NCT06104553RecruitingPhase 1/Phase 2
Study of SHR-A1912 with other treatments for B-cell lymphoma
This trial tests a new combination therapy for adults with B-cell non-Hodgkin lymphoma that has returned or not responded to prior treatment. The goal is to see if adding SHR-A1912 to other treatments can help shrink tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06104592RecruitingPhase 2
Radiation before CAR T-cell therapy for high-risk large B-cell lymphoma
This trial tests if giving radiation to all visible tumor sites before standard CAR T-cell therapy can improve outcomes for people with high-risk large B-cell lymphoma. You may be eligible if you have at least one large tumor (5 cm or bigger) that can be targeted with radiation.
Tampa, FloridaAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,228 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,761 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.