Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,147
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,230 total
- NCT06572605RecruitingPhase 1/Phase 2
Radiation plus talquetamab for myeloma outside the bone
This trial tests combining radiation therapy with a targeted drug called talquetamab for multiple myeloma that has formed tumors outside the bone (extramedullary disease). It aims to see if this combination can shrink or control these tumors and improve outcomes.
Duarte, CaliforniaAges 18 years+ - NCT06573723Recruiting
Rare disease registry at Hospital Italiano
This study collects information from patients with certain rare diseases to better understand them. If you have one of these conditions and receive care at Hospital Italiano de Buenos Aires, you may be able to join.
Buenos Aires, Buenos AiresAges Any age - NCT06574568RecruitingPhase 1
Study of YKST02 for relapsed or refractory multiple myeloma
This study tests a new drug called YKST02 for people with multiple myeloma that has come back or hasn't responded to other treatments. The goal is to see if it can help when other therapies have stopped working.
Beijing, Beijing MunicipalityAges 18–75 - NCT06574594Recruiting
Testing shingles vaccine response when stopping methotrexate in RA
This trial looks at whether pausing methotrexate (a common RA medication) affects how well the shingles vaccine (Shingrix) works for people with rheumatoid arthritis. It may help decide if stopping methotrexate temporarily can improve vaccine protection.
SeoulAges 19 years+ - NCT06575296RecruitingPhase 1
Revumenib after stem cell transplant for acute leukemia
This trial tests a drug called revumenib to help keep leukemia from coming back after a stem cell transplant. It is for people with specific genetic types of acute leukemia who have recently had or will soon have a transplant.
Duarte, CaliforniaAges 2 years+ - NCT06575790Recruiting
Comparing simplified meal boluses to carb counting for teens with automated insulin pumps
This study tests if a simpler way of calculating meal insulin works as well as counting carbohydrates for teens using hybrid closed loop (automated insulin) systems. If you're a teen with type 1 diabetes and use an automated pump, this trial could help find an easier mealtime routine.
Aurora, ColoradoAges 14–26 - NCT06575842Recruiting
Accuracy of glucose monitors during surgery in youth with type 1 diabetes
This trial tests how well continuous glucose monitors (CGMs) work during surgery and hospital stays in young people with type 1 diabetes. It aims to make sure these devices give accurate readings when they are most needed.
Aurora, ColoradoAges 2–26 - NCT06576271RecruitingPhase 1
Testing a new drug for lupus and related lung disease
This study tests an experimental drug called GSK4527363. It is first being given to healthy volunteers to check safety, then to people with lupus (SLE) and people with connective tissue disease-related lung disease (CTD-ILD). The goal is to see if the drug is safe and how the body processes it.
Scottsdale, ArizonaAges 18–65 - NCT06576505Recruiting
Understanding sarcoidosis: a study on the immune system
This study looks at how the immune system works in people with sarcoidosis. It may help researchers find better ways to diagnose or treat the disease in the future.
Stockholm, Stockholm CountyAges 18–90 - NCT06577909RecruitingPhase 2
Prednisone with or without IVIg for ITP in pregnancy
This trial compares two treatments for pregnant women with ITP (immune thrombocytopenia) and low platelet counts. It tests whether adding IVIg (immune globulin) to standard prednisone (steroid) therapy is more effective than prednisone alone.
Beijing, Beijing MunicipalityAges 18–50 - NCT06579222Recruiting
Managing other health conditions in rheumatoid arthritis
This study looks at how to better manage health conditions like heart disease or diabetes in people with rheumatoid arthritis. Participants will work with their rheumatology clinic to improve overall health.
Waterloo, OntarioAges 18–80 - NCT06580301RecruitingPhase 1/Phase 2
Study of YK012 for relapsed or refractory B-ALL
This trial tests a new drug, YK012, for people with a certain kind of B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not gotten better after standard therapies. It aims to see if the drug is safe and works against these leukemia cells that have the CD19 marker.
Guangzhou, GuangdongAges 18–75 - NCT06581081Recruiting
CAR-T therapy with or without stem cell transplant for B-cell leukemia
This trial tests a CD19-targeted CAR-T cell therapy (S1904) for people with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. After CAR-T, some patients may go on to a stem cell transplant. The goal is to see if the CAR-T can lead to remission and who needs a transplant.
Beijing, Beijing MunicipalityAges 12–65 - NCT06581562RecruitingPhase 1
Testing rituximab plus AB-101 for autoimmune diseases
This trial tests a new treatment (AB-101) combined with rituximab for people with certain autoimmune diseases like rheumatoid arthritis, pemphigus vulgaris, vasculitis, or lupus. It is for those who have not had success with standard therapies.
Plantation, FloridaAges 18 years+ - NCT06581640RecruitingPhase 2
BCMA-targeting CAR-T cells for relapsed/refractory myeloma
This trial tests a new type of immune cell therapy (CAR-T cells) that targets a protein called BCMA on multiple myeloma cells. It is for people whose myeloma has come back or has not responded to other treatments.
Xiamen, FujianAges 18–80 - NCT06584006RecruitingPhase 2
Boosting low white blood cells in blood cancer patients
This trial tests a combination of two medicines—thymalfasin and IL-2—to see if they can help raise low white blood cell counts (lymphocytes) in people with blood cancers. If you have low lymphocytes from your cancer or its treatment, this study may offer a way to boost your immune system.
Xiamen, FujianAges 18 years+ - NCT06583980Recruiting
Study for people with arthritis who want better symptom control
This trial is testing a new approach to help people with arthritis who are not satisfied with their symptom control. It may be a good fit if you have rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis and are still struggling with fatigue, pain, or how the disease affects your daily life.
FrederiksbergAges 18–100 - NCT06584045Recruiting
Testing a bile-based treatment for adult encephalitis
This study tests a natural bile-derived medicine (Calcus Bovis Sativus) to see if it can help adults with new or recent brain inflammation (encephalitis). It focuses on people whose encephalitis is caused by the immune system or a virus, and who have not fully recovered.
Wuhan, HubeiAges 18 years+ - NCT06584110Recruiting
Buddy-up exercise program for dementia and caregiver
This study tests a buddy-up program where a person with mild to early moderate dementia and their family caregiver do physical activities together using video calls. It aims to see if exercising together helps both their health and well-being.
Hong KongAges 18 years+ - NCT06584552RecruitingPhase 2
Testing a probiotic for early childhood eczema
This study tests if a friendly bacteria called Lactobacillus paracasei, given as a powder, can help control eczema in young children. It's for kids 3 months to 3 years old with mild to moderate eczema who are not taking strong medications.
Randwick, New South WalesAges 3 months–3 years - NCT06585124Recruiting
Study of t cells in lymphoma patients with HLH
This study looks at specific immune cells (T cells) in people who have a rare condition called Hemophagocytic Lymphohistiocytosis (HLH) together with an aggressive lymphoma. It aims to better understand how these cells behave, which may lead to improved diagnosis or treatment.
Rome, LazioAges 18 years+ - NCT06585631Recruiting
Collaborative care for young men with HIV and substance use
This study looks at how to better support young men living with or at risk for HIV while also addressing substance use. You'll work with a care team that helps you stay healthy and connected to services.
Baltimore, MarylandAges 15–29 - NCT06585514RecruitingPhase 1/Phase 2
CAR T-cell therapy for hard-to-treat lupus
This trial tests a treatment where your own immune cells are modified to attack and destroy lupus-causing B cells. It's for people with lupus (SLE) that hasn't improved with standard treatments.
Beijing, Beijing MunicipalityAges 3–65 - NCT06586177Recruiting
Study on Long-Term Effects of B Cell Therapies for MS
This study looks at how B cell therapies (a type of medicine for MS) create a long-lasting effect in people with relapsing-remitting multiple sclerosis. It aims to understand how these treatments work over time so doctors can better predict benefits and risks.
DüsseldorfAges 18–60
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,763 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.