Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,068 recruiting studies in this area right now.
By phase
- Not applicable3,005
- Phase 21,062
- Phase 1794
- Phase 1/Phase 2441
- Phase 3435
- Phase 4233
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma328
- Asthma194
- Lymphoma179
- Rheumatoid Arthritis131
- Type 1 Diabetes131
- Atopic Dermatitis123
- Systemic Lupus Erythematosus121
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia96
- Autoimmune Diseases79
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Hodgkin Lymphoma64
- Diabetes Mellitus, Type 163
- Leukemia63
- Type 1 Diabetes Mellitus63
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca64
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic50
- City of Hope Medical Center49
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California498
- Maryland198
- Alabama179
- Florida152
- Arizona150
- Massachusetts118
- New York116
- Texas112
- Illinois82
- Colorado81
Recruiting studies6,068 total
- NCT06608017RecruitingPhase 2/Phase 3
Yupingfeng powder for allergic rhinitis
This trial tests whether Yupingfeng powder, a traditional Chinese herbal remedy, can help relieve allergic rhinitis symptoms like sneezing and a runny nose. It may be an option if your allergic rhinitis is linked to a deficiency in lung and spleen energy (a concept in Chinese medicine).
ShatinAges 18 years+ - NCT06612294Recruiting
Asthma symptom perception study for older adults
This study looks at how older adults with asthma perceive their symptoms. It aims to improve understanding of asthma symptoms in people over 60 with uncontrolled asthma.
New York, New YorkAges 60 years+ - NCT06612242Recruiting
Early vs. late tracheostomy in Guillain-Barre patients
This trial looks at whether having a tracheostomy (a breathing tube placed through the neck) earlier or later helps people with Guillain-Barre syndrome who need a breathing machine. It reviews past cases to see which timing leads to better recovery.
Kfar SabaAges 18 years+ - NCT06609356RecruitingEarly Phase 1
Reducing high insulin levels in type 1 diabetes
This study tests if adding a non-insulin medication can lower the amount of insulin needed while improving heart and metabolic health in people with type 1 diabetes. It may also help understand how this approach works in people with a genetic form of diabetes (GCK-MODY).
Nashville, TennesseeAges 18–60 - NCT06615232Recruiting
Vaginal washing study for cervical health
This study looks at how vaginal washing (cleaning inside the vagina) might affect inflammation in the cervix. If you wash inside your vagina, you may be able to take part and help us learn more about its effects on your body.
MombasaAges 18–50 - NCT06600568Recruiting
New treatment for T-cell cancers
This trial is testing a new approach to treat T-cell cancers (leukemia and lymphoma). It may be an option for adults with these cancers who are otherwise in reasonably good health.
NaplesAges 18 years+ - NCT06612554Recruiting
Zinc supplements for HIV patients with low CD4 counts
This trial tests whether taking zinc supplements helps HIV patients who have low CD4 cell counts even when their virus is well-controlled. If your zinc levels are normal but your immune cells are slow to recover, this might be for you.
BarcelonaAges 18 years+ - NCT06614270Recruiting
CAR-NK cell therapy for severe autoimmune diseases
This trial tests a new type of immune cell therapy using modified natural killer cells (CAR-NK) that target a protein called CD19 and produce helpful signals (IL-10 and IL-15). It is for people with certain autoimmune diseases that have not improved with standard treatments or have come back after getting better.
Hangzhou, ZhejiangAges 18–65 - NCT06182436Recruiting
Virtual reality for pain during eczema injection
This trial tests whether playing a virtual reality game during a dupilumab injection (for eczema) can help reduce pain and anxiety. It's for kids and teens aged 6 to 17 who are already taking or about to start this medicine.
Montreal, QuebecAges 6–17 - NCT06455332Recruiting
Optic nerve test to predict MS after first symptoms
This study looks at how early damage to the optic nerve (the nerve that connects your eye to your brain) might predict future multiple sclerosis (MS) in people who have just had their first neurological symptoms (called a clinically isolated syndrome). You will have an MRI of your eyes and a special eye scan to see if these tests can help doctors know who is more likely to develop MS.
LilleAges 18–55 - NCT06589999Recruiting
Better MRI for spinal cord inflammation
This study tests a new MRI technique called MP2RAGE to see if it can better detect spinal cord damage caused by inflammatory diseases like multiple sclerosis. If you already need a spinal MRI for your condition, this extra scan may help doctors find problems earlier.
ParisAges 18 years+ - NCT06594068RecruitingPhase 4
Anifrolumab in breastfeeding mothers with lupus
This study is looking at how the lupus medicine anifrolumab passes into breast milk and affects mothers and their babies. It is for women who are already taking anifrolumab for lupus and are breastfeeding a baby born at 32 weeks or later.
Las Vegas, NevadaAges 18–130 - NCT06588478RecruitingPhase 2
Study of pirtobrutinib for CLL or SLL
This trial tests a new drug called pirtobrutinib for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for those whose cancer has come back or not responded to treatment, including a prior BTK inhibitor, and also for those who have never been treated but have a specific genetic change (17p deletion).
Chandler, ArizonaAges 18 years+ - NCT06585774RecruitingPhase 3
Axatilimab plus steroids for new chronic GVHD
This study tests a new drug called axatilimab combined with steroids as a first treatment for chronic graft-versus-host disease (GVHD) after a stem cell transplant. It aims to see if this combination helps control symptoms better than steroids alone.
Birmingham, AlabamaAges 12 years+ - NCT06596148Enrolling by invitation
Improving shingles vaccination for veterans on immune-suppressing drugs
This trial tests a way to help doctors encourage more veterans to get the Shingrix vaccine, which protects against shingles. It focuses on veterans taking medications that weaken the immune system.
San Francisco, CaliforniaAges Any age - NCT06588205Recruiting
Understanding MYC changes in aggressive B-cell lymphomas
This study looks at how changes in the MYC gene affect the outlook for people with certain fast-growing lymphomas, including diffuse large B-cell lymphoma and high-grade B-cell lymphoma. It aims to better understand the tumor environment and how these patients respond to standard chemotherapy.
AlessandriaAges 18–79 - NCT06594939RecruitingPhase 2
Combination chemo for elderly DLBCL patients
This trial tests a new combination of targeted therapies and chemotherapy for older adults with a diagnosis of diffuse large B-cell lymphoma. The goal is to see if this approach is safe and effective for people who may not be able to tolerate standard treatment.
Milwaukee, WisconsinAges 70 years+ - NCT06585514RecruitingPhase 1/Phase 2
CAR T-cell therapy for hard-to-treat lupus
This trial tests a treatment where your own immune cells are modified to attack and destroy lupus-causing B cells. It's for people with lupus (SLE) that hasn't improved with standard treatments.
Beijing, Beijing MunicipalityAges 3–65 - NCT06591429Recruiting
A study on hidden inflammation in multiple sclerosis
This study uses brain scans to look for hidden inflammation in people with multiple sclerosis who have not yet started a strong treatment. It aims to understand how this inflammation affects the disease and to help guide future therapies.
St Louis, MissouriAges 18 years+ - NCT06598345Enrolling by invitation
Pet fish care for better diabetes management in teens
This study tests if taking care of a pet fish can help kids aged 10-13 with type 1 diabetes improve their blood sugar control and take more responsibility for their diabetes care.
Durham, North CarolinaAges 10–13 - NCT06584110Recruiting
Buddy-up exercise program for dementia and caregiver
This study tests a buddy-up program where a person with mild to early moderate dementia and their family caregiver do physical activities together using video calls. It aims to see if exercising together helps both their health and well-being.
Hong KongAges 18 years+ - NCT06599411Recruiting
Skin biomarkers for inflammatory disease treatment
This study looks for clues in your skin and blood that could predict how well you'll respond to treatments for conditions like eczema, psoriasis, or lupus. It aims to help doctors choose the best therapy for you.
ParisAges 18 years+ - NCT06586177Recruiting
Study on Long-Term Effects of B Cell Therapies for MS
This study looks at how B cell therapies (a type of medicine for MS) create a long-lasting effect in people with relapsing-remitting multiple sclerosis. It aims to understand how these treatments work over time so doctors can better predict benefits and risks.
DüsseldorfAges 18–60 - NCT06586619Recruiting
Tai chi and qigong for older adults with HIV
This study tests whether a remotely taught tai chi and qigong program can improve mood and well-being in people aged 50–75 who are living with HIV. You can join from home using a smartphone.
Miami, FloridaAges 50–75
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,068 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,217 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.