Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,230 recruiting studies in this area right now.
By phase
- Not applicable3,147
- Phase 21,063
- Phase 1819
- Phase 1/Phase 2442
- Phase 3425
- Phase 4238
- Phase 2/Phase 396
Top conditions
- Multiple Sclerosis343
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis140
- Type 1 Diabetes133
- Atopic Dermatitis129
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia122
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)66
- Leukemia64
- Type 1 Diabetes Mellitus63
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)73
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals60
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center44
Where studies are running
- California491
- Maryland195
- Alabama175
- Florida144
- Arizona142
- New York123
- Massachusetts119
- Texas118
- Illinois81
- Colorado77
Recruiting studies6,230 total
- NCT01965132Recruiting
Biologic and targeted therapy registry for arthritis patients
This registry is collecting information about people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis who are starting or needing biologic or targeted medicines. It may help researchers better understand how these treatments work in real life.
SeoulAges 18 years+ - NCT00756769Recruiting
Gullah community study for lupus symptoms and risk factors
This study looks at lupus in people from the Gullah community in South Carolina, including people with lupus and healthy comparison participants. It may help researchers better understand who is at risk and how lupus shows up in this community.
Charleston, South CarolinaAges 2 years+ - NCT00039689Recruiting
Blood collection study for newly diagnosed HIV research
This research study collects blood cells from people recently diagnosed with HIV who haven't started HIV medicines yet. Researchers use these samples to understand how HIV affects the immune system and develop better treatments.
Bethesda, MarylandAges 18–120 - NCT00001778Recruiting
Understanding HTLV Infection and HAM/TSP Disease
This research study evaluates people with HTLV infection, a virus that can cause a nerve disorder called HAM/TSP. Researchers want to better understand who gets this condition and why, which may help develop future treatments.
Bethesda, MarylandAges 18–120 - NCT01441089Recruiting
Donate blood for genetic testing in an NIH research study
This study collects blood from people already in an NIH (National Institutes of Health) clinical research program to run genetic tests. It may help researchers understand cancer and related inherited conditions by studying DNA changes.
Bethesda, MarylandAges 3 years+ - NCT01137825Recruiting
Older patient cancer registry for a health check
This study is a registry that collects information from older adults who may be dealing with cancer. It includes a short health and function check to help doctors understand needs and guide care, even for people who turn out not to have cancer.
Boone, North CarolinaAges 65 years+ - NCT00626496Recruiting
Family study for certain blood and immune disorders
This study looks at families where more than one close, blood-related person has a lymphoproliferative disorder (a group of conditions where the lymph system makes too many abnormal cells). It aims to better understand why these disorders run in families and how they may be inherited or related.
Rochester, MinnesotaAges 18–100 - NCT01425892Recruiting
Study of how Sjogren’s disease starts and changes over time
This study follows people with Sjogren’s disease to understand how it develops and how symptoms naturally change over time. The goal is to improve understanding and future care rather than provide a new immediate treatment.
Bethesda, MarylandAges 16–100 - NCT00032513Recruiting
Genetic study of chronic active Epstein-Barr virus disease
This research study looks for genetic factors that may explain why some people develop severe, long-lasting Epstein-Barr virus (EBV) infection. Researchers will study blood and tissue samples from patients with this rare condition, their healthy relatives, and unrelated volunteers to understand the disease better.
Bethesda, MarylandAges 1–120 - NCT02000687Recruiting
Long-term follow-up after islet transplant graft failure
This study follows people over the long term after their islet transplant fully stops working. It aims to learn what happens after complete graft loss and monitor health outcomes over time.
Miami, FloridaAges 18–75 - NCT00576069Recruiting
Study airflow limits in moderate asthma
This trial looks at why airflow is limited in people with moderate-to-severe persistent asthma who are already on stable treatment. It may help researchers better understand what drives breathing trouble and how to target it.
Lakewood, CaliforniaAges 10–95 - NCT00005917Recruiting
Understanding Chediak-Higashi Syndrome: A Research Study
This study helps researchers understand Chediak-Higashi syndrome, a rare genetic condition that affects how the body fights infections and controls bleeding. Participation involves medical evaluation and may help guide future treatments.
Bethesda, MarylandAges 1 month–70 years - NCT00470327Recruiting
Study of how interstitial lung disease naturally changes
This study looks at how interstitial lung disease (lung scarring) typically progresses over time. It may help researchers understand what to expect and what changes to watch for.
Chicago, IllinoisAges 18 years+ - NCT00867269Recruiting
Study of causes and progression of low CD4 blood cells
This study looks for what causes and how idiopathic low CD4 cells happen over time, using blood and tissue samples. It may help doctors learn why this occurs and how to better track people with it.
Bethesda, MarylandAges 18 years+ - NCT01484236Recruiting
Lymphangioleiomyomatosis patient registry in France
This trial is a national registry that collects information about people with lymphangioleiomyomatosis to better understand the condition and care over time. It may help by contributing real-world data from patients with sporadic disease or related tuberous sclerosis.
LyonAges 18 years+ - NCT00177268Recruiting
Collecting blood and tissue samples in skin diseases research
This study collects blood, urine, and possibly small tissue samples to learn more about cutaneous T-cell lymphoma (CTCL) and either eczema or atopic dermatitis. It may help researchers better understand these skin conditions and improve future treatments.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT00055172Recruiting
Understanding Genetic Causes of Immune System Disorders
This research study investigates why some people have weak or poorly functioning immune systems. By studying you and your relatives, researchers hope to identify genetic factors that cause these conditions and eventually develop better treatments.
Bethesda, MarylandAges 6 months–99 years - NCT01799538RecruitingPhase 1/Phase 2
Inhaled albuterol for lung disease LAM
This Phase 1/2 study tests whether breathing in albuterol can improve symptoms or lung function in people with lymphangioleiomyomatosis (LAM). It’s mainly about safety and early signs of benefit by targeting airflow problems.
Bethesda, MarylandAges 18–100 - NCT01962415RecruitingPhase 2
Reduced-intensity stem cell transplant for non-cancer disorders
This trial tests whether a gentler (reduced-intensity) conditioning treatment before a stem cell transplant works for non-cancer diseases. It uses specific donor stem cell matches and checks heart, lung, liver, and kidney function to help lower transplant stress while still aiming for benefit.
Pittsburgh, PennsylvaniaAges 2 months–55 years - NCT00412594RecruitingPhase 2
Cladribine plus rituximab for hairy cell leukemia
This trial tests whether a combination of two medicines—cladribine and rituximab—can treat hairy cell leukemia. You might be able to join if your leukemia is confirmed and you meet timing, blood test, and health requirements.
Houston, TexasAges 18 years+ - NCT01225913RecruitingPhase 4
Testing airflow limits in asthma flare-ups
This Phase 4 study looks at what causes breathing airways to narrow during asthma worsening, in people with stable, treated asthma. It may help improve how clinicians understand and manage asthma flare-ups.
Lakewood, CaliforniaAges 10–80 - NCT00097292Recruiting
Preventing Type 1 Diabetes in At-Risk People
This study looks for people at high risk of developing type 1 diabetes (based on family history or blood markers) and follows them over time to understand disease development. The goal is to eventually prevent or delay type 1 diabetes in people who don't have it yet.
Orange, CaliforniaAges 2–45 - NCT00943514Recruiting
Study of bronchiectasis and why infections keep coming back
This study follows children (age 5+) and adults with bronchiectasis or ongoing/repeated lung infections to learn what makes infections more likely. It mainly looks at non–cystic fibrosis causes, but may include some related conditions to compare differences.
Bethesda, MarylandAges 5–100 - NCT00398177Recruiting
Study blood and tissue changes in lymphoma and Hodgkin’s
This study looks at samples of tissue removed during routine procedures to better understand Hodgkin’s disease and non-Hodgkin’s lymphoma. It may help researchers learn more about what these cancers look like in tissue.
Stanford, CaliforniaAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,230 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,763 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.