Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,227 recruiting studies in this area right now.
By phase
- Not applicable3,140
- Phase 21,067
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4236
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis342
- Multiple Myeloma333
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes132
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona140
- New York122
- Massachusetts119
- Texas118
- Illinois82
- Colorado77
Recruiting studies6,227 total
- NCT06538181RecruitingPhase 1
Testing pacritinib for VEXAS syndrome
This trial tests a new drug called pacritinib for people with VEXAS syndrome, a rare autoinflammatory condition. The goal is to see if pacritinib can help control symptoms like rashes, joint pain, and low blood counts.
St Louis, MissouriAges 18 years+ - NCT06337097Recruiting
Monitoring heart enzyme during immunotherapy
This study is for people starting immunotherapy with checkpoint inhibitors. It checks a heart enzyme (troponin) to see if the treatment affects your heart, so your doctor can monitor and manage any changes early.
Houston, TexasAges 18 years+ - NCT07315191RecruitingPhase 4
Finerenone for IgA vasculitis with mild proteinuria in children
This trial tests if the drug finerenone can help children with IgA vasculitis (HSP nephritis) who have mild protein in their urine. It aims to protect kidney function without using stronger medications like steroids.
Beijing, Beijing MunicipalityAges 3–18 - NCT06793475Recruiting
Aponermin before CAR-T for multiple myeloma with extramedullary disease
This trial tests whether a drug called aponermin, given before CAR-T cell therapy, can help people with multiple myeloma that has come back or not responded to treatment and has spread to soft tissues (extramedullary disease). The goal is to make the CAR-T therapy work better.
BeijingAges 18 years+ - NCT07156084RecruitingPhase 4
HPV vaccine long-term effect study for young adults
This study checks if one dose of the 9-valent HPV vaccine given at ages 9-11 still protects you 6 years later. It is for people who only had that single dose and no other HPV shots.
Québec, QuebecAges 15–17 - NCT06037187Recruiting
Blood clotting study for immune skin diseases
This study looks at how immune-related skin diseases like bullous pemphigoid and lupus affect blood clotting. The results could help doctors better understand and manage clotting risks in these patients.
Omaha, NebraskaAges 19 years+ - NCT06333275Recruiting
Boosting immunity after CAR-T therapy
This trial checks if giving vaccines after CAR-T cell therapy can help your immune system fight off preventable diseases. It is for adults with certain blood cancers who are about to get CAR-T treatment.
BernAges 18 years+ - NCT07302113Recruiting
Online thinking skills program for teens with lupus
This study tests a virtual (online) program to help teens with lupus improve thinking and daily life skills. It is designed for youth ages 13–18 with childhood-onset lupus.
Toronto, OntarioAges 13–18 - NCT07328711RecruitingEarly Phase 1
Immunotherapy for chronic hepatitis B after HBsAg loss
This trial tests an immunomodulatory therapy for people with chronic hepatitis B who have already cleared the surface antigen (HBsAg) with a specific treatment. It aims to understand why some people achieve a cure and how to improve outcomes.
Beijing, Beijing MunicipalityAges 18–60 - NCT06802406Recruiting
Nutrition support for transplant or cell therapy patients
This study tests a program to help patients who are getting a transplant or cell therapy and have trouble getting enough food. It provides nutrition resources to improve their health during treatment.
Stanford, CaliforniaAges 8–80 - NCT05925452Recruiting
Genalumab for children with active systemic juvenile arthritis
This trial studies whether a medicine called genalumab can reduce inflammation and improve symptoms in children with active systemic juvenile idiopathic arthritis (sJIA). It also checks how safe the treatment is, including possible side effects.
Beijing, BenjingAges 2–17 - NCT07295535Recruiting
Nasal immune responses to respiratory viruses in healthy and immunocompromised people
This study looks at how the nose's immune system responds to common respiratory viruses in both healthy people and those with weakened immune systems. It aims to understand how long these responses last.
Pavia, PaviaAges 18–90 - NCT06803758Recruiting
Testing teicoplanin allergy with your own blood
This study tests a new way to check if you are allergic to the antibiotic teicoplanin using your own blood serum. It aims to help doctors know for sure if you had a severe allergic reaction during a past surgery.
SouthamptonAges 18 years+ - NCT07293624Enrolling by invitation
Diet and inflammation after weight-loss surgery
This study looks at how your diet affects inflammation and stomach symptoms after weight-loss surgery. You'll fill out food records and have blood tests to see how your eating habits relate to your health.
Istanbul, UskudarAges 18–65 - NCT07287345RecruitingPhase 4
Colchicine’s effect on inflammation after heart bypass surgery
This trial tests whether the drug colchicine can reduce inflammation after planned coronary artery bypass graft (CABG) surgery. It may help patients recover better by lowering inflammatory markers.
Lexington, KentuckyAges 18–99 - NCT06907329Recruiting
NMN supplement trial for middle-aged adults with metabolic issues
This trial tests whether a sustained-release nicotinamide mononucleotide (NMN) supplement can improve immune aging and metabolism in people aged 50-70 who are overweight or have fatty liver, pre-diabetes, or mild type 2 diabetes.
ShanghaiAges 50–70 - NCT06968000RecruitingPhase 1/Phase 2
Testing a clean air device for better recovery after surgery
This trial tests whether a special air filter (Biow) placed in your hospital room can help you sleep better and recover faster after surgery. It is for patients having elective general surgery, especially liver or bile duct procedures, who are at risk for cell stress.
Madrid, MadridAges 18 years+ - NCT07169487RecruitingPhase 1
Methylene Blue for Side Effects of Cancer Immunotherapy
This trial tests if methylene blue can help people who develop side effects called CRS or ICANS after treatments like CAR-T cells or bispecific antibodies. It is a first-in-human study to find a safe dose.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06926062Recruiting
Improving HPV vaccine communication in pharmacies
This study looks at whether training pharmacy staff in communication and vaccination workflows can improve HPV vaccine recommendations and uptake. If you are a parent or guardian of a child aged 9–17 who has not yet completed the HPV vaccine series, you may be eligible to participate.
University Park, PennsylvaniaAges 18 years+ - NCT05984394Recruiting
Study of immune cells in new antisynthetase syndrome with lung disease
This study looks at special immune cells (T cells) in people newly diagnosed with antisynthetase syndrome that has affected their lungs. It aims to understand how these cells are involved in the condition, which could lead to better treatments.
DijonAges 18 years+ - NCT06131112Recruiting
PET scan for heart inflammation in sarcoidosis
This study tests if a special PET scan with 64Cu-DOTATATE can detect inflammation in the heart caused by sarcoidosis. It may help diagnose heart sarcoidosis more accurately in people with symptoms or known disease.
CopenhagenAges 18 years+ - NCT07172360RecruitingPhase 3
Study of VC005 tablets for active ankylosing spondylitis
This trial tests a new tablet called VC005 to see if it helps reduce pain and stiffness in people with active ankylosing spondylitis. It's a phase 3 study, meaning it's one of the final steps before the drug may be approved for wider use.
Beijing, Beijing MunicipalityAges 18–70 - NCT07388680RecruitingPhase 2/Phase 3
Pirfenidone for radiation lung injury with or without immune pneumonia
This trial tests if pirfenidone capsules can help treat lung damage caused by radiation therapy, with or without immune-related pneumonia. It may be suitable for people with mild to moderate lung function impairment who have recently developed radiation lung injury.
Hefei, AnhuiAges 18–75 - NCT07276425Recruiting
Dupilumab for prurigo nodularis: long-term effects
This study follows people with moderate-to-severe prurigo nodularis who are starting dupilumab. It looks at how the medicine works over time and how it affects the immune system, to help understand long-term benefits.
Utrecht, UtrechtAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,227 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,696 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.