Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,229 recruiting studies in this area right now.
By phase
- Not applicable3,142
- Phase 21,065
- Phase 1822
- Phase 1/Phase 2446
- Phase 3423
- Phase 4237
- Phase 2/Phase 394
Top conditions
- Multiple Sclerosis341
- Multiple Myeloma332
- Asthma194
- Lymphoma182
- Rheumatoid Arthritis142
- Type 1 Diabetes133
- Atopic Dermatitis128
- Systemic Lupus Erythematosus125
- Acute Lymphoblastic Leukemia123
- HIV Infections116
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 169
- Hodgkin Lymphoma67
- Rheumatoid Arthritis (RA)65
- Leukemia64
- Acute Myeloid Leukemia62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)90
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- M.D. Anderson Cancer Center63
- Novartis Pharmaceuticals63
- AstraZeneca57
- City of Hope Medical Center47
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama176
- Florida143
- Arizona141
- New York123
- Massachusetts119
- Texas117
- Illinois82
- Colorado77
Recruiting studies6,229 total
- NCT03980886Recruiting
Study of inflammation in children with eosinophilic esophagitis
This study looks at how inflamed the esophagus is in children who have eosinophilic esophagitis (EoE). It may help doctors better understand what’s driving symptoms like trouble swallowing and food getting stuck.
San Diego, CaliforniaAges 1–65 - NCT03981003Recruiting
Blood tests to track brain and nerve changes in MS
This study measures blood markers (from a serum blood sample) to see how nerve and brain changes relate to MS disease activity and disability over time. It may help researchers better monitor MS, especially in people followed in the OFSEP program.
AmiensAges 15 years+ - NCT03984253Recruiting
Swiss Severe Asthma Register for adults and children
This study set up a long-term asthma registry to better understand people with severe asthma and what treatments they use. If you fit the asthma severity requirements, you may be asked for consent and basic health information so the team can follow your asthma over time.
Liestal, Basel-LandschaftAges 1 year+ - NCT03983603Recruiting
Plant stanols and asthma symptoms prevention
This trial tests whether eating plant stanols (a natural substance found in some foods) can help prevent asthma symptoms in people with stable allergic asthma. You would need to take a daily chew and avoid certain cholesterol-lowering products during the study.
Maastricht, LimburgAges 18–70 - NCT03987633Recruiting
Study links health records and samples to understand health gaps
This study asks people affected by a specific illness (or their family member) to share saliva (and sometimes blood) and answer health and quality-of-life questions. The goal is to better understand and reduce health inequality by matching new information with medical records.
Wolverhampton, West MidlandsAges 6 years+ - NCT03988764Recruiting
Checking monogenic diabetes wrongly labeled as type 1
This trial looks at people who were diagnosed with diabetes before age 25 as either type 1 or “not sure which type.” It may help confirm whether the cause is genetic (monogenic) rather than type 1, which can change treatment choices.
Montreal, QuebecAges 1 day–25 years - NCT03993262RecruitingPhase 2
Bortezomib for severe autoimmune encephalitis after rituximab
This Phase 2 study tests whether bortezomib can improve outcomes and safety in adults with severe autoimmune encephalitis. It focuses on people whose condition is confirmed by brain-related autoantibodies and who have already received rituximab.
München, BavariaAges 18 years+ - NCT04002947RecruitingPhase 2
Acalabrutinib with chemo for untreated aggressive B-cell lymphoma
This Phase 2 trial studies whether adding acalabrutinib to intensive chemo (DA-EPOCH-R or R-CHOP) works better for people newly diagnosed with aggressive diffuse large B-cell lymphoma (DLBCL) or related high-grade B-cell lymphomas. It may help shrink cancer and control the disease by targeting lymphoma in two different ways.
Bethesda, MarylandAges 18 years+ - NCT04005638Recruiting
Biobank for people with autoimmune blood cell disorders
This study collects and stores biological samples (a “biobank”) from people with autoimmune cytopenia, so researchers can learn more about the condition. If you qualify, your samples may help future studies and improve care, and it’s based on voluntary consent.
PessacAges 18 years+ - NCT04047628RecruitingPhase 3
MS patients with active relapsing disease comparing two treatment plans
This Phase 3 study compares the best standard MS treatment (chosen by your doctors) versus an approach called autologous hematopoietic stem cell transplant (AHSCT) for people with highly active, treatment-resistant relapsing multiple sclerosis. It aims to see which option controls MS disease activity better and keeps you safer over time.
Palo Alto, CaliforniaAges 18–55 - NCT06580002RecruitingPhase 2
Can Riluzole Help with Chemo Brain? A Pilot Study
This study tests if a medicine called riluzole (currently used for ALS) can help with 'chemo brain' – memory and thinking problems after cancer treatment. It is for people who feel their mental sharpness has declined after breast cancer therapy, certain chemotherapies, or brain radiation.
Orange, CaliforniaAges 18 years+ - NCT07401732Recruiting
Dysphagia in rheumatoid arthritis study
This study looks at swallowing problems (dysphagia) in people with rheumatoid arthritis to understand how common they are and what might cause them. It uses a flexible scope through the nose to examine swallowing function.
Tanta, ElgharbiaAges 18 years+ - NCT07701954RecruitingPhase 1
Testing a new drug for people with allergies and high IgE
This early-phase trial tests a new medication, LCA-0061, in healthy people with high IgE levels (a sign of allergies). Part B specifically includes those with a peanut allergy. The study aims to see how safe the drug is and how the body processes it.
Mississauga, OntarioAges 18–55 - NCT03955445RecruitingPhase 3
Study for long-term iptacopan in C3G or IC-MPGN
This Phase 3 trial looks at how well and how safely iptacopan works over the long term for people with C3G or IC-MPGN. You may be able to join if you already finished a specific earlier study and you’re currently healthy enough for long-term treatment.
Aurora, ColoradoAges 12–100 - NCT07247279Recruiting
Study of myasthenia gravis treatments in Russia
This study tracks how generalized myasthenia gravis (a condition that causes muscle weakness) is treated in Russia. By looking at real-world data, researchers hope to learn more about which treatments work best for people like you.
Kazan'Ages 18 years+ - NCT07315997Recruiting
Heart health study for people with rheumatoid arthritis
This study looks at whether calcium in the heart arteries and a blood test (troponin) can help predict heart disease risk in people with rheumatoid arthritis. It may help doctors better prevent heart attacks and strokes.
Boston, MassachusettsAges 35–79 - NCT05957913Enrolling by invitationPhase 2
Testing antiviral drugs to control Epstein-Barr virus in MS
This Phase 2 study tests whether certain antiviral medicines can reduce Epstein-Barr virus (EBV) activity. If you have multiple sclerosis and evidence of EBV infection, the results may help clarify new ways to target EBV-related disease activity.
Boston, MassachusettsAges 18 years+ - NCT07580898RecruitingPhase 1
Testing MOON101 Safety for Peanut Allergy Treatment
This study tests whether a new drug called MOON101 is safe for people with peanut allergies. The goal is to see if it might help your immune system tolerate peanuts better and reduce severe allergic reactions.
Little Rock, ArkansasAges 4–55 - NCT06201494Recruiting
Studying early symptoms of asthma in children
This study follows children and teens who are being checked for asthma for the first time. It aims to learn more about the early symptoms of asthma to improve diagnosis and treatment.
PragueAges 3–18 - NCT07622368RecruitingPhase 1
Testing IBI3031 for Active Thyroid Eye Disease
This early-stage trial tests a new drug called IBI3031 to treat active thyroid eye disease (TED), a condition where the immune system attacks muscles and tissue around the eyes, causing swelling, bulging, and sometimes double vision. The study aims to see if this drug can reduce inflammation and improve symptoms.
Shenyang, LiaoningAges 18–75 - NCT07133997RecruitingPhase 1
Combination therapy for relapsed CD19+ B-cell leukemia
This trial tests a new combination of three drugs for patients with relapsed or treatment-resistant CD19-positive B-cell acute lymphoblastic leukemia. It aims to see if adding the drugs venetoclax and asparaginase to blinatumomab can improve outcomes.
Duarte, CaliforniaAges 12–55 - NCT07434869Recruiting
Blood and image markers for ECP response in lung transplant CLAD
This study looks at whether blood tests and MRI scans can predict how well ECP (a blood-filtering treatment) works for people with CLAD after a lung transplant. If you’ve been prescribed ECP for CLAD and haven’t had it before, you may be able to help researchers find better ways to tailor treatment.
Boston, MassachusettsAges 7 years+ - NCT07280013RecruitingPhase 1
Cemsidomide with elranatamab for multiple myeloma
This trial tests a new drug combination (cemsidomide and elranatamab) for people with multiple myeloma that has come back after previous treatments. The goal is to see if the combination is safe and works better than current options.
Gilbert, ArizonaAges 18 years+ - NCT06289673RecruitingPhase 4
Collecting info to start treatment for new leukemia or lymphoma
This study gathers key health information at the start of treatment for children and teens newly diagnosed with certain types of leukemia or lymphoma. The goal is to find the best way to begin therapy right away, without waiting for extra tests.
San Diego, CaliforniaAges 1–18
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,229 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,721 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.