Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,050 recruiting studies in this area right now.
By phase
- Not applicable2,999
- Phase 21,056
- Phase 1792
- Phase 1/Phase 2437
- Phase 3435
- Phase 4233
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma327
- Asthma193
- Lymphoma178
- Rheumatoid Arthritis131
- Type 1 Diabetes130
- Atopic Dermatitis124
- Systemic Lupus Erythematosus119
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia95
- Autoimmune Diseases77
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Diabetes Mellitus, Type 163
- Hodgkin Lymphoma63
- Leukemia63
- Mantle Cell Lymphoma62
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic49
- City of Hope Medical Center48
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California496
- Maryland199
- Alabama178
- Florida149
- Arizona148
- Massachusetts116
- New York116
- Texas112
- Illinois83
- Colorado82
Recruiting studies6,050 total
- NCT07420296RecruitingPhase 3
Modified zipper therapy for AQP4-positive neuromyelitis optica
This trial tests a new treatment called modified zipper therapy for people with neuromyelitis optica spectrum disorder (NMOSD) who have a specific antibody (AQP4-IgG) in their blood. It aims to stop a recent attack and improve recovery.
TianjinAges 18–80 - NCT07424027Recruiting
Central vein sign in multiple sclerosis extension study
This study is for people already in the CAVS-MS study. It uses MRI scans to look at a specific sign in the brain that may help diagnose multiple sclerosis.
Los Angeles, CaliforniaAges 18–65 - NCT07422337Recruiting
Vaccine protection after blinatumomab for childhood leukemia
This study checks how well vaccines you got as a baby still protect you after treatment with blinatumomab for B-cell leukemia or lymphoma. It helps doctors understand if you may need extra vaccines.
Little Rock, ArkansasAges 1–23 - NCT07419243RecruitingPhase 1/Phase 2
Tolerance in milk and egg allergy in children
This study watches how milk and egg allergies change naturally over time or after oral immunotherapy (OIT) in children. It helps researchers understand how the immune system adapts, aiming to improve treatment for food allergies.
Madrid, MadridAges 4–17 - NCT07423013Recruiting
Teprotumumab treatment for active thyroid eye disease
This trial tests a new version of an antibody treatment (teprotumumab) for people with active thyroid eye disease. It aims to reduce bulging and inflammation of the eyes, and you must have had symptoms for less than 9 months to join.
BeijingAges 18–80 - NCT07416656Recruiting
Checking blood sugar test accuracy for arthritis patients on sulfasalazine
This study checks if the medicine sulfasalazine affects a blood sugar test (HbA1c) in people with inflammatory arthritis. If you have arthritis, take sulfasalazine, and have higher blood sugar or diabetes, this trial may help understand your glucose levels.
Silkeborg, Central JutlandAges 18 years+ - NCT07423637Recruiting
Early automated insulin delivery for new type 1 diabetes
This study tests whether starting an automated insulin delivery (AID) system soon after a type 1 diabetes diagnosis helps improve blood sugar control and reduces future health problems. The AID system combines a pump and continuous glucose monitor to automatically adjust insulin.
EspooAges 7–16 - NCT07424222RecruitingPhase 1
Ruxolitinib for a serious immune reaction after CAR T therapy
This trial tests a drug called ruxolitinib for a rare but serious condition called IEC-HS that can happen after CAR T cell treatment. The goal is to see if ruxolitinib can calm this overactive immune response.
Baltimore, MarylandAges 18–99 - NCT06791681RecruitingEarly Phase 1
ESO-T01 for returning or hard-to-treat multiple myeloma
This trial tests a new treatment called ESO-T01 for people with multiple myeloma that has come back or is not responding to at least two prior therapies. It aims to see if this therapy is safe and can help control the disease.
Wuhan, HubeiAges 18 years+ - NCT06769386Recruiting
Muscle Oxygen in Rheumatoid Arthritis
This study looks at how muscles use oxygen in people with rheumatoid arthritis. You will do some exercise tests to measure your muscle oxygen levels, which may help doctors understand how the disease affects your muscles.
Kırşehir, MerkezAges 18–65 - NCT06820125Recruiting
Combined cognitive and motor rehab for MS
This trial compares cognitive rehab alone versus cognitive plus motor rehab using high-tech tools for people with multiple sclerosis who have mild thinking problems and some walking difficulty. It aims to see if adding movement exercises improves outcomes more than cognitive training alone.
Verona, veronaAges 18 years+ - NCT06819774RecruitingPhase 3
Testing cetirizine injection for acute hives
This trial tests an injectable medication (cetirizine, a type of antihistamine) to see if it quickly relieves itching and hives in adults with acute (short-term) hives. It is for people whose hives have lasted less than 6 weeks and who still have bothersome symptoms.
Beijing, Beijing MunicipalityAges 18–65 - NCT06183645Recruiting
Predicting CIDP decline during IVIg treatment changes
This study looks at people with CIDP who are stable on IVIg treatment to see if we can predict when they might get worse if their treatment is adjusted. It aims to make treatment management easier and more personalized.
Liège, LiègeAges 18–99 - NCT07416201Recruiting
Study of Immune System Aging in Down Syndrome
This study is looking at how the immune system changes over time in people with Down syndrome, and how it may be affected by removal of the thymus gland. The goal is to understand why people with Down syndrome may age faster or have different immune health.
Bethesda, MarylandAges 1–120 - NCT07413809RecruitingPhase 3
Preventing nausea after stem cell transplant: olanzapine vs dexamethasone
This trial compares two anti-nausea drug regimens (one with olanzapine, one with dexamethasone) to prevent delayed nausea and vomiting after a stem cell transplant for multiple myeloma. It aims to find which is better at controlling these side effects.
Ningbo, ZhejiangAges 18–65 - NCT07408219Recruiting
Study of Remibrutinib for chronic hives
This study follows people with chronic spontaneous urticaria (long-lasting hives with no clear cause) who are starting a new medicine called remibrutinib or dupilumab. It aims to see how well these treatments work in everyday life.
East Hanover, New JerseyAges 18–100 - NCT07409428RecruitingPhase 3
Study of HMPL-760 plus R-GemOx for relapsed or refractory DLBCL
This trial tests an experimental drug called HMPL-760 combined with a standard chemo-immunotherapy regimen (R-GemOx) for people whose diffuse large B-cell lymphoma (DLBCL) has come back or stopped responding to treatment. The goal is to see if adding HMPL-760 works better than the standard approach alone.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07409181RecruitingPhase 2
Testing an experimental pill for active lupus (SLE)
This study tests an experimental daily pill (BI 3000202) for people with active lupus (SLE) to see if it can reduce disease activity. It compares different doses against a placebo, and you must already be on stable lupus background treatment.
Beverly Hills, CaliforniaAges 18–74 - NCT07415551RecruitingPhase 2
New drug for chronic hives that don't respond to allergy pills
This study tests an investigational medication called lesigercept for people with chronic hives that don't get better with standard allergy pills. The goal is to see if it can reduce itching and hives better than placebo.
Sofia, SofiaAges 18–75 - NCT07409246RecruitingPhase 1
Study of ABBV-438 for multiple myeloma patients
This trial tests a new intravenous treatment, ABBV-438, for adults with multiple myeloma that has returned or not responded to prior therapies. It aims to see if the drug is safe, tolerable, and how it moves through the body.
Duarte, CaliforniaAges 18 years+ - NCT07416162Recruiting
Study of iptacopan for PNH or C3G in Korea
This trial tests a medicine called iptacopan for people with paroxysmal nocturnal hemoglobinuria (a rare blood disorder) or C3 glomerulopathy (a kidney disease). It aims to see if the drug is safe and effective for Korean patients.
JeollanamAges 18–99 - NCT07412470RecruitingPhase 2/Phase 3
Testing frexalimab vs tacrolimus for new kidney transplant patients
This trial compares a new drug called frexalimab to the standard drug tacrolimus in people who are getting their first kidney transplant. The goal is to see if frexalimab works better and has a safer side effect profile.
San Francisco, CaliforniaAges 18–70 - NCT07409103RecruitingPhase 2
Testing ELV001 for active rheumatoid arthritis
This study tests a new medication, ELV001, for people with active rheumatoid arthritis who haven't improved enough with methotrexate and a TNF inhibitor. The goal is to see if different doses of ELV001 are safe and can help reduce joint pain and swelling.
Gilbert, ArizonaAges 18–75 - NCT07412704RecruitingPhase 1/Phase 2
Study of BMS-986528 for hard-to-treat rheumatoid arthritis
This trial tests a new drug called BMS-986528 for people with rheumatoid arthritis that is difficult to treat. It aims to see if the drug can help when other treatments haven't worked well.
La Jolla, CaliforniaAges 18–65
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,050 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,115 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.