NaCl clinical trials

Reducing IV fluids in ICU patients

This trial tests if lowering the amount of salt water (sodium chloride) given as maintenance fluids or 'fluid creep' can help critically ill adults in the ICU recover better. It compares two ways of managing daily fluids to see which is safer and more effective.

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

RNA therapy for ATTR amyloidosis with heart involvement

This trial tests an experimental RNA therapy (nucresiran) for people with transthyretin amyloidosis that causes heart problems (cardiomyopathy). It aims to lower the abnormal protein buildup to help heart function.

Ephedrine for faster muscle relaxant in elderly patients

This trial tests whether giving a small dose of ephedrine (a medicine that raises blood pressure) can make the muscle relaxant rocuronium work faster in older adults. It aims to help patients 80+ get a breathing tube placed more quickly during surgery.

Tranexamic acid for less swelling and bruising after eye socket surgery

This study tests whether giving tranexamic acid (a medicine that helps blood clot) locally or through an IV can reduce swelling and bruising after eye socket surgery.

Nasal spray oxytocin for benzodiazepine withdrawal

This trial tests if a nasal spray containing the hormone oxytocin can help reduce withdrawal symptoms when stopping benzodiazepine (benzos) medications like Valium. You might be eligible if you have been taking a moderate to high daily dose of a benzodiazepine and are entering a hospital program to taper off.

Ketamine for depression in intensive care patients

This study tests whether low-dose ketamine infusions can reduce depressive symptoms in patients staying in the intensive care unit for at least 6 days. Ketamine is a medication that may work differently than standard antidepressants and could provide faster relief.

Testing an Anti-Inflammatory Drug for Heart Disease With TET2 Mutation

This study tests whether a medication that blocks inflammation (called an IL-1 beta inhibitor) can reduce blood vessel inflammation in people with both heart disease and a specific genetic change in their blood cells (TET2 mutation). It aims to see if targeting this type of inflammation can help lower heart risks.

How a gut hormone affects blood pressure after eating in healthy adults

This study looks at how a natural gut hormone called GIP affects blood pressure after a meal. It may help find new ways to treat blood pressure problems after eating.

Pain relief after a hysterectomy

This study tests if numbing the top of the vagina (vaginal cuff) with a local anesthetic can reduce the need for pain medicine after a hysterectomy done by laparoscopy (small cuts in the belly). If you are having this surgery for a non-cancerous condition or cancer, you may be able to join.

Trilaciclib to prevent low blood cell counts in limited-stage small cell lung cancer

This trial tests whether taking trilaciclib alongside standard chemotherapy can help prevent low blood cell counts (myelosuppression) in people with limited-stage small cell lung cancer. It may help you stay stronger during treatment.

Numbing injection for pain after tonsil surgery

This study tests a numbing injection near a nerve in your nose to see if it can reduce pain and help you recover faster after tonsillectomy. It is a non-drug approach that may offer an alternative to strong pain medicines.

Neck injection for dizziness linked to neck pain

This trial tests whether a local anesthetic injection in the neck (paravertebral lidocaine) can reduce dizziness that is related to neck pain or stiffness. It may help if your dizziness started along with neck pain, trauma, or limited movement.

Lidocaine for easier recovery after laparoscopic surgery

This study tests whether giving lidocaine (a numbing medicine) through an IV can help you wake up more smoothly and with less discomfort after laparoscopic gallbladder or gynecologic surgery. If you are generally healthy and having one of these specific surgeries, you may be a good fit.

Lidocaine through feeding tube to reduce nausea after weight-loss surgery

This study tests whether delivering lidocaine (a numbing medication) through a feeding tube during weight-loss surgery can reduce nausea and vomiting afterward. You would receive this medication as part of the surgery procedure to see if it helps you feel better in recovery.

Comparing ways to reduce blood loss during fibroid surgery

This trial tests different methods to minimize blood loss during laparoscopic surgery to remove uterine fibroids. It may help women with heavy bleeding or trouble getting pregnant.

Testing a New Yellow Fever and Dengue Vaccine

This study tests a new vaccine designed to improve protection against yellow fever and dengue fever in healthy adults. Researchers want to see if this vaccine works better than existing ones and is safe.

Comparing fluids' effect on heart function

This trial compares two types of IV fluids (colloids and crystalloids) to see how they affect heart function. It is open to healthy adults who are not pregnant and have no known medical problems.

Albumin plus diuretics for cirrhosis-related leg swelling

This study tests whether giving albumin (a protein) along with water pills helps reduce leg swelling in people with cirrhosis and ascites. It may be an option if your leg swelling hasn't improved with standard diuretics alone.

Certolizumab for repeated embryo transfer pregnancy failure

This Phase 3 study tests certolizumab to help people with repeated embryo transfer failures achieve a clinical pregnancy. It may be an option if your infertility has no known cause and you meet the other study checks.

Drinking vs. IV fluids to protect kidneys from contrast dye

This trial compares drinking fluids by mouth versus receiving fluids through an IV to prevent kidney injury from CT contrast dye. It may be a good option if you have mild to moderate kidney disease and need a contrast CT while in the emergency department.

Desmopressin to improve safety after kidney biopsy

This trial tests whether desmopressin can make kidney biopsy safer by reducing bleeding risk. It compares safety outcomes after a biopsy in people who meet specific blood, medication, and health criteria.

Device to treat gum shrinkage and black triangles between teeth

This trial tests a medical device (RDM36) to see if it safely and effectively treats gum shrinkage and black triangles between the front teeth, which can affect your smile.

Pre-surgery romiplostim for patients with low platelets having heart surgery

This trial tests if giving romiplostim before heart surgery can safely increase low platelet counts. It may help patients with low platelets avoid bleeding complications during and after surgery.