Clinical trials
ARDS (Moderate or Severe) clinical trials
Below are recruiting ards (moderate or severe) clinical trials, each written for real people, not researchers. We’re tracking 1,473 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05172960Recruiting
Study of a new heart valve for severe aortic stenosis
This trial tests a new version of a heart valve (SAPIEN X4) placed without open-heart surgery. It's for people with severe aortic stenosis who have symptoms like shortness of breath or chest pain.
La Jolla, CaliforniaAges Any age - NCT05177809Recruiting
Study of RFC1 gene changes in patients and healthy controls
This study tracks people with a specific genetic cause of RFC1-related disease, and compares them with healthy people without nervous system or mental health conditions. It helps researchers learn how the condition develops over time and what changes to watch for.
Melbourne, VictoriaAges 18 years+ - NCT05090540Enrolling by invitation
Less Invasive vs Usual Surgery for Mitral Valve Leaks
This trial compares a less invasive catheter procedure to the standard surgical operation to treat “secondary” leaking of the mitral valve. It may help people with significant valve leak decide which approach works better for reducing symptoms and heart strain.
Saint-DenisAges 18–90 - NCT05049668Enrolling by invitation
Long-term follow-up for people from the RACE study
This study checks on people who took part in the earlier RACE trial and collected long-term health information. It helps researchers understand how the treatments given in that trial affect patients over time.
ParisAges Any age - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT05012111Recruiting
Studying bone marrow failure over time
This study looks at the natural course of bone marrow failure conditions, both inherited and acquired. It aims to understand how these diseases progress over time, which may help guide future treatments.
Bethesda, MarylandAges 2–99 - NCT05026138Recruiting
Study of severe HPV disease and why it keeps coming back
This study follows people with severe or hard-to-treat HPV-related conditions (and some closely related partners/household contacts) to learn how the virus causes illness and how the immune system responds. It may help doctors better predict who will develop severe disease and guide future treatments.
Bethesda, MarylandAges 3–100 - NCT04961593Recruiting
Studying caspofungin dosing in very ill children
This study looks at how caspofungin works in children who are very sick and in the pediatric intensive care unit. It helps doctors better choose dosing to keep the medicine at the right level.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT04961580Recruiting
Study of ceftazidime dosing in sick children
This trial measures how ceftazidime (an antibiotic) moves through the body and how it works in children with severe infections in the pediatric intensive care unit. It may help doctors choose safer, more effective dosing for kids.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT04860375Recruiting
Program for severe COPD after a hospital breathing flare-up
This trial studies a coordinated (multidisciplinary) care program for people with severe COPD who were recently hospitalized for worsening breathing symptoms. It may help reduce future flare-ups and improve day-to-day breathing by coordinating multiple types of care in a COPD center.
Gothenburg, VGRAges 40–100 - NCT04905264Recruiting
Studying factors and care quality after severe brain injury
This study looks at how outcomes and care quality vary for people with serious acquired brain injuries while in a rehabilitation unit. It may help clinicians understand what care works best and why.
AlessandriaAges 18 years+ - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04896606RecruitingPhase 1/Phase 2
Matched donor immune therapy for mild to moderate COVID-19
This early-phase study tests immune cells from a matched family donor (made to target the COVID-19 virus) to see if they can help people with mild-to-moderate COVID-19 who are hospitalized and at higher risk for getting sicker. It aims to check safety first and also look for signs of benefit.
Valhalla, New YorkAges 18–65 - NCT03753412Recruiting
Rehab program for adults after ICU recovery on ECMO
This trial looks at a recovery and rehabilitation approach for adults who were very sick and needed a machine called ECMO to support breathing and heart function. It may help people regain strength and function after a severe ICU illness.
LondonAges 18 years+ - NCT04774536RecruitingPhase 1/Phase 2
CRISPR gene-edited bone marrow transplant for severe sickle cell
This Phase 1/2 study tests a CRISPR-edited bone marrow (stem cell) transplant to treat severe sickle cell disease. It aims to reduce dangerous sickle-related complications by changing the patient’s stem cells before transplant.
Los Angeles, CaliforniaAges 12–35 - NCT04850456Recruiting
Gamma globulin treatment for critically ill children with inflammation surge
This trial studies whether giving “human gamma globulin” can improve outcomes in very sick children in the ICU who have a severe infection causing an extreme inflammation reaction (“inflammatory storm”). If you’re in the hospital ICU with this complication, the study may offer a targeted treatment strategy and careful monitoring.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT04786262RecruitingPhase 3
A study of VX-880 and VX-017 for type 1 diabetes
This study tests two investigational drugs, VX-880 and VX-017, for people with type 1 diabetes who have trouble controlling their blood sugar and have frequent severe low blood sugar episodes. The goal is to see if these drugs can improve blood sugar control and reduce dangerous lows.
Duarte, CaliforniaAges 18–65 - NCT04819841RecruitingPhase 1/Phase 2
Gene correction using your own stem cells to improve sickle disease
This trial tests a gene-correction treatment that changes sickle hemoglobin (HbS) into normal hemoglobin (HbA) using your own stem cells. It may help reduce severe sickle cell complications for people with severe disease who meet specific safety and medical criteria.
Los Angeles, CaliforniaAges 12–50 - NCT04712539RecruitingPhase 2
Baloxavir and oseltamivir for severe flu in immune-compromised people
This trial tests whether two flu medicines—baloxavir and oseltamivir—work better to treat influenza in people with weakened immune systems (like transplant or blood cancer patients). It may help reduce severe complications, especially when flu affects the lungs or is at high risk to do so.
Houston, TexasAges 12 years+ - NCT04750564Recruiting
BreEStim to help arm movement after long-term stroke
This pilot study tests a type of nerve stimulation (BreEStim) to improve arm and finger movement in people with chronic stroke-related stiffness. It may help if you have persistent, measurable muscle tightness and are medically stable.
Houston, TexasAges 18–75 - NCT04652115RecruitingPhase 2
Defibrotide for severe COVID-19 in adults
This trial tests defibrotide to see if it improves outcomes in people hospitalized with severe COVID-19. You may be considered if you have confirmed infection, abnormal chest imaging, and meet specific severity and safety requirements.
Boston, MassachusettsAges 18–100 - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Redwood City, CaliforniaAges 18–64 - NCT04583644Recruiting
Fetal airway balloon procedure for severe left lung underdevelopment
This pilot study tests a fetal procedure (placing a tiny balloon in the fetus’s airway) to improve lung growth in pregnancies affected by severe left congenital diaphragmatic hernia (CDH). You may be eligible if your baby’s condition is isolated to the left side and the testing shows very high lung underdevelopment, and if you can meet study and payment requirements.
San Francisco, CaliforniaAges 18 years+ - NCT04558736RecruitingPhase 2
Haploidentical transplant for severe aplastic anemia in children
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
Memphis, TennesseeAges Up to 21 years
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Common questions
- Are there clinical trials for ards (moderate or severe)?
- Yes. Clin2 currently lists 1,473 recruiting ards (moderate or severe) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ards (moderate or severe) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ards (moderate or severe) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.