Clinical trials
Bipolar clinical trials
Below are recruiting bipolar clinical trials, each written for real people, not researchers. We’re tracking 241 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06059313Recruiting
Personality study for people with memory or behavior changes
This study looks at how personality may have changed before the onset of different types of memory or behavior disorders (like frontotemporal dementia, Alzheimer's, or bipolar disorder). Researchers will talk with a family member or close friend who knew you well before the illness started.
NantesAges 18 years+ - NCT06071858Recruiting
Enhanced coordinated care for early psychosis
This trial studies an enhanced version of coordinated specialty care (CSC) for people experiencing their first episode of psychosis. It aims to improve outcomes by providing more intensive support and coordination among different healthcare providers.
Belmont, MassachusettsAges Any age - NCT05878730Recruiting
Melatonin study for people stable on long-term lithium
This trial tests whether taking melatonin (a sleep-related hormone) changes how your body responds to lithium in people with bipolar disorder who are currently stable. It may help researchers understand lithium’s effects and how sleep/circadian timing could matter.
Paris, Île-de-France RegionAges 18–70 - NCT05358574Recruiting
Shoulder implant follow-up study after a salvage bipolar surgery
This study looks at how safe and well a specific shoulder implant (“bipolar system”) works after it’s used as a backup plan during surgery. You may join if you needed this implant because the usual reverse shoulder attachment couldn’t be done during the operation.
HamburgAges 18 years+ - NCT05877014RecruitingPhase 3
Compare two fixation methods for adult arm shaft fractures
This trial tests whether one surgical technique (for stabilizing the upper-arm bone using a rod placed inside the bone) works better than another for adult humeral shaft fractures. It may help find the approach that leads to better healing and recovery.
DijonAges 18 years+ - NCT05786066RecruitingPhase 2
Test whether blocking AMPA changes ketamine’s suicide relief
This study looks at whether an “AMPA receptor blocker” changes how ketamine affects suicidal thoughts in people with depression that hasn’t improved with usual treatments. If you qualify, you may receive ketamine and the study medicine, while continuing your regular mental health care.
West Haven, ConnecticutAges 21–65 - NCT05686278Recruiting
Study of long-term outcomes after hip hemiarthroplasty
This is an observational study that follows people over time after hip hemiarthroplasty (a partial hip replacement). It aims to understand how well Corin hip devices work long-term in everyday care, and what outcomes to expect.
Amboise, FranceAges 18 years+ - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+ - NCT05698589Recruiting
Therapy program to reduce self-stigma in mental health
This study looks at how a program may help people with long-term mental health conditions feel less shame about their diagnosis (self-stigma). It is meant for adults who are stable enough to participate and who speak French.
BordeauxAges 18 years+ - NCT05648591RecruitingPhase 4
Iloperidone study for teens with schizophrenia or bipolar I
This Phase 4 study checks how safe and well-tolerated iloperidone is when used in a typical, open-label way for teenagers. It may help doctors better understand side effects and safety in teens with schizophrenia or bipolar I disorder.
Dothan, AlabamaAges 12–17 - NCT05537376Recruiting
Peer-led suicide prevention support for veterans with serious mental illness
This study tests a suicide-prevention program delivered by trained peer specialists (other people with similar lived experience) to help veterans who are currently having suicidal thoughts. It aims to add ongoing support and improve safety and recovery for veterans with serious mental health conditions.
San Diego, CaliforniaAges 18 years+ - NCT05491538Recruiting
Work-focused social skills training for veterans with mental illness
This study tests a program to help veterans with serious mental illness improve social skills for work and find jobs near the VA. It aims to see if the program is acceptable and feasible for participants.
Minneapolis, MinnesotaAges 18 years+ - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05157620Recruiting
Yoga and exercise program for veterans with severe mental illness
This trial tests an exercise and yoga-style wellness program to help veterans with severe mental health conditions feel and function better. It may help with symptoms and overall well-being, especially if your condition is currently stable.
Pittsburgh, PennsylvaniaAges 18–70 - NCT04987229Enrolling by invitationPhase 3
Kid’s long-term safety follow-up for OLZ and SAM treatment
This study checks how safe a kid’s ongoing treatment is over a longer period. It is mainly for children who already finished a related study and may benefit from continuing the same medicines.
Dothan, AlabamaAges 10–17 - NCT04678258Recruiting
Study without x-ray guidance for treating atrial flutter
This trial tests a way to do a heart procedure for “atrial flutter” with less or no x-ray use. It may help reduce radiation exposure while still aiming to cure the abnormal rhythm.
Fürth, BavariaAges 18 years+ - NCT04580134RecruitingPhase 4
Clozapine study for people with a specific schizophrenia or bipolar type
This trial tests whether clozapine works better for people whose illness fits a specific “biotype-1” pattern. It may help reduce ongoing symptoms, but it also requires close safety monitoring.
Hartford, ConnecticutAges 18–60 - NCT03522064RecruitingPhase 2
HRD-positive advanced prostate cancer trial with androgen therapy and chemo
This Phase 2 study tests whether blocking male hormones (androgen therapy) plus the chemotherapy drug carboplatin can shrink advanced prostate cancer in men with specific DNA repair problems. It is for cases where prostate-specific antigen (PSA) is rising even though testosterone is already kept very low.
Sydney, New South WalesAges 18 years+ - NCT03260400Recruiting
Muscle and nerve implants to improve bionic arm control
This study tests a new approach that uses small nerve and muscle grafts along with temporary electrodes to help people with an above-wrist arm amputation get better control of a bionic arm. If it works, it could make prosthetics feel more natural and easier to use.
Ann Arbor, MichiganAges 22–75 - NCT03217110Recruiting
Brain stimulation study for thinking and control
This trial tests whether stimulating the cerebellum (a part of the brain involved in coordination and learning) can improve “cognitive control,” or the ability to focus and manage thoughts. You may be able to join if you have a diagnosis they are specifically enrolling for and you can safely complete the stimulation and study procedures.
Iowa City, IowaAges 18–90 - NCT02878408Recruiting
Study of immune and genetics factors in bipolar or schizophrenia
This study looks at how the immune system, genetics, inflammation, and past exposures may relate to bipolar disorder or schizophrenia. It may help researchers understand the cause and find better ways to support people with these conditions.
Créteil, FranceAges 16 years+ - NCT00762866Enrolling by invitation
Study of mental health traits using genetic and brain measurements
This study collects information about mental health symptoms and body/genetic samples to better understand how different mental health conditions are related. Some people may also have brain scans (PET or MRI) if they can safely complete them.
Nashville, TennesseeAges 16–65 - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99
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Common questions
- Are there clinical trials for bipolar?
- Yes. Clin2 currently lists 241 recruiting bipolar studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.