Clinical trials
Bone Pain clinical trials
Below are recruiting bone pain clinical trials, each written for real people, not researchers. We’re tracking 37 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07197645RecruitingPhase 1
Samarium for pain from bone cancer
This trial tests a new radioactive drug (samarium) given once to reduce severe bone pain from cancer that has spread to the bones. It is for people whose pain is not controlled by current treatments and who cannot have standard radiation.
Miami, FloridaAges 18 years+ - NCT03858205Recruiting
Low-dose radiation to relieve pain from bone tumors
This trial studies whether low-dose radiation can reduce pain from a specific bone lesion caused by multiple myeloma. It may help people whose main problem is painful bone metastasis, with targeted treatment to the painful spot.
Duarte, CaliforniaAges 18 years+ - NCT05419518RecruitingPhase 2
Higher-dose radiation to ease pain from metastatic tumors
This Phase 2 study tests whether a stronger (higher-dose) radiation plan can better reduce pain from tumors that have spread to bone or other areas. It’s meant to help people live more comfortably by targeting painful spots while avoiding certain high-risk situations.
Hamilton, New JerseyAges 18 years+ - NCT07300735Recruiting
Can citrus compounds or allergy meds prevent G-CSF bone pain?
This study tests whether taking a combination of two natural compounds (diosmin and hesperidin) similar to those from citrus fruits, or the allergy medicine loratadine, can prevent or reduce bone pain caused by G-CSF injections—a common treatment to boost white blood cells in people with blood cancers.
AlexandriaAges 18–65 - NCT06065449RecruitingPhase 3
Comparing two radiation therapies for painful bone metastases
This trial compares two types of radiation therapy to relieve pain from cancer that has spread to the bones. It aims to see whether a more targeted, high-dose approach (SBRT) works better than standard palliative radiation.
Houston, TexasAges 18 years+ - NCT07090122Recruiting
Spinal tumor treatment: ablation plus radiation vs radiation alone
This study compares two treatments for cancer that has spread to the spine. One group receives radiofrequency ablation (a heat-based treatment to destroy tumor cells) plus bone strengthening, followed by radiation. The other group receives radiation alone. The goal is to see which approach better controls pain and prevents spine problems.
Minneapolis, MinnesotaAges 18 years+ - NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT07023692Enrolling by invitation
Using visual and sound tricks to ease pain and worry during a bone marrow test
This trial tests whether watching a video or listening to sounds can help reduce pain and anxiety during a bone marrow aspiration or biopsy. It's for adults who are either healthy volunteers or patients without a blood cancer diagnosis, and who need this test at the clinic in Lund, Sweden.
Lund, Skåne CountyAges 18 years+ - NCT04803773Recruiting
MRI-guided ultrasound to treat painful bone tumors
This feasibility study tests an MRI-guided focused ultrasound treatment for certain painful bone tumors, including bone metastases and osteoid osteoma. The goal is to see if the treatment can be safely delivered to the right spot and help with pain.
StrasbourgAges 18 years+ - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+ - NCT06487013Recruiting
Focused ultrasound for painful bone metastases
This trial tests a focused ultrasound treatment called ArcBlate to relieve pain from bone cancer that has spread. It is for people who have moderate to severe pain despite cancer therapy and have chosen not to have surgery or radiation for that pain.
New Taipei CityAges 18 years+ - NCT05406063Recruiting
Focused radiation for bone metastases causing pain
This trial studies a precise type of radiation given in multiple small sessions to treat bone metastases that are causing pain. It may help shrink or control the spots in the bone while aiming to reduce side effects by targeting the area closely.
Winterthur, Canton of ZurichAges 18 years+ - NCT05883241RecruitingPhase 1
Sound-based treatment for fracture pain
This early-stage study tests a device that uses sound to reduce pain from a bone fracture and improve daily quality of life. If you have mild-to-moderate fracture pain and can follow the device routine, you may be able to try this treatment while avoiding other pain medicines and fracture-area therapies.
Trumbull, ConnecticutAges 18–80 - NCT07008703RecruitingPhase 1/Phase 2
Study of sss40 for cancer bone pain
This trial tests a new injection called sss40 to treat moderate-to-severe pain caused by cancer that has spread to the bones. The goal is to see if it is safe and effective for people whose pain is not being controlled by current treatments.
Zhengzhou, HenanAges 18 years+ - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT04693377Recruiting
Freezing tumor treatment plus targeted radiation for painful bone spread
This study tests whether combining a “freezing” procedure (cryoablation) with focused external radiation (SBRT) can reduce pain from bone metastases. It’s for people with certain cancers that have spread to bone and are having significant pain in a specific bone spot.
Houston, TexasAges 18 years+ - NCT05421416RecruitingPhase 2
Loratadine to prevent bone pain after stem cell transplant treatment
This trial tests loratadine (an allergy medicine) to see if it can prevent bone pain caused by a growth-factor injection used during lymphoma or multiple myeloma treatment. It may help reduce pain around the time you get that injection and your upcoming stem cell transplant.
Edmonton, AlbertaAges 18 years+ - NCT07558278RecruitingPhase 4
LINQ procedure vs standard care for sacroiliac joint pain
This study compares a new procedure called LINQ—which stabilizes the sacroiliac joint (the joint where your spine connects to your pelvis)—against standard pain management for chronic sacroiliac joint pain. The trial tests whether this procedure reduces pain and disability better than medications and physical therapy alone.
Shenandoah, TexasAges 21 years+ - NCT07547215Recruiting
TRAQ Minimally Invasive Sacroiliac Joint Fusion Study
This study tests a minimally invasive surgical procedure called TRAQ to treat chronic sacroiliac joint (SIJ) pain—a type of lower back and buttock pain. The procedure may help if you've had pain for at least 6 months that didn't improve with non-surgical treatments and have already benefited from diagnostic joint injections.
Tucson, ArizonaAges 21 years+ - NCT04211259RecruitingEarly Phase 1
Loratadine to reduce bone pain during stem cell collection
This early trial studies whether loratadine (an allergy medicine) can reduce bone pain caused by G-CSF, which is used to help your body collect stem cells. If you have multiple myeloma and are preparing for stem cell mobilization, this may make treatment-related bone pain more tolerable.
New Brunswick, New JerseyAges 18 years+ - NCT05841186Recruiting
Timing Pegfilgrastim Dose in Breast Cancer Patients
This study looks at whether changing the timing of pegfilgrastim (a medicine used to help prevent low white blood cell counts during chemotherapy) affects outcomes in people with primary breast cancer. It may help your care team choose the best dosing schedule for you during treatment.
Guangzhou, GuangdongAges 18–70 - NCT05996367Recruiting
Single radiation dose for painful myeloma bone lesions
This trial is testing whether a single dose of radiation can effectively relieve bone pain caused by multiple myeloma. It is designed for people who have a painful bone lesion and are stable on or off treatment.
São Paulo, São PauloAges 18–85 - NCT07209280Enrolling by invitation
New screw system for pelvic fracture repair
This trial tests a newer type of screw to fix certain pelvic fractures. It aims to see if it works better than the standard screw for helping bones heal and for you to get back on your feet.
Salt Lake City, UtahAges 18–80 - NCT07536399RecruitingPhase 3
Bone Marrow Treatment for Jaw Joint Pain Relief
This study tests whether injecting your own bone marrow cells into your jaw joint during a minimally invasive procedure can reduce pain and improve jaw function better than arthroscopy alone. It's for people with significant jaw pain that hasn't improved with conservative treatments like NSAIDs, physical therapy, and bite splints.
New York, New YorkAges 18–75
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Common questions
- Are there clinical trials for bone pain?
- Yes. Clin2 currently lists 37 recruiting bone pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bone pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bone pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.