Clinical trials
Brain Cancer clinical trials
Below are recruiting brain cancer clinical trials, each written for real people, not researchers. We’re tracking 256 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07755397RecruitingPhase 1
Study of JBI-778 for lung, brain, and salivary gland tumors
This trial tests a new oral medication, JBI-778, in patients with certain types of lung cancer, brain tumors, or salivary gland cancer. The drug is designed to target specific genetic changes in these tumors, and the study aims to assess its safety and effectiveness.
Surat, GujaratAges 18 years+ - NCT05375617Recruiting
Study for newly diagnosed childhood cancers in Europe
This study follows children and teens with newly diagnosed certain leukemia (ALL) and certain favorable brain tumors to learn best care and outcomes. It may help your team compare standard treatments and monitor health over time.
New York, New YorkAges 3–21 - NCT05528939Recruiting
Training attention skills for children after cancer
This trial tests a computer-based “attention-control training” program to see if it’s doable and helpful for children who finished treatment for acute lymphoblastic leukemia or a brain tumor. It also looks at how acceptable the program is for both kids and caregivers.
Washington D.C., District of ColumbiaAges 8–16 - NCT06613841RecruitingEarly Phase 1
Brain tumor imaging study for glioblastoma patients
This study uses special PET scans (fluciclovine and FDG) and advanced MRI to create a detailed metabolic profile of glioblastoma. It may help doctors better understand your tumor before surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06618703Recruiting
Brain radiation in childhood: early hormone check
This study follows children who had brain radiation for cancer to check for early hormone changes. It aims to catch and treat any hormone problems sooner.
AngersAges 4–18 - NCT07524777Recruiting
Ganoderma Spores for Mood After Thyroid Cancer Surgery
This study tests whether Ganoderma spores (a natural mushroom extract) can improve mood and depression in women who've had thyroid cancer surgery. The spores may work by changing the bacteria in your gut, which scientists believe affects brain health and mood.
Hangzhou, ZhejiangAges 18–80 - NCT06807619RecruitingPhase 1
Sotorasib for people with brain tumors needing surgery
This study tests a drug called sotorasib in people with brain tumors who are already scheduled for surgery or a biopsy. It may help find out if the drug can reach and treat the tumor.
Basking Ridge, New JerseyAges 18 years+ - NCT05689619Recruiting
Silibinin after one brain metastasis surgery for lung or breast cancer
This trial studies silibinin, a natural substance, to help prevent brain metastasis from coming back after surgery. It is for people with lung (NSCLC) or breast cancer who have exactly one small brain metastasis that is fully removed and has a specific lab marker in the brain tissue.
GenovaAges 18–70 - NCT07505173RecruitingPhase 2
Targeted radiation plus osimertinib for brain metastases from EGFR-mutant lung cancer
This trial tests adding a brain-sparing radiation technique to the targeted therapy drug osimertinib for people with EGFR-mutant lung adenocarcinoma that has spread to the brain and is causing symptoms. The goal is to see if this combination can better control the brain tumors while protecting the hippocampus, a key memory area.
TianjinAges 18–75 - NCT05658731Recruiting
Radiation planning study to protect thinking in children
This study compares how radiation is planned to see whether it better protects thinking and memory in children and young adults. It may help future patients by learning which planning approach leads to better cognitive (thinking) outcomes.
Washington D.C., District of ColumbiaAges 1–26 - NCT05115474RecruitingPhase 2
Screening brain MRI study for stage IV breast cancer
This trial checks whether taking screening brain MRI scans in people with stage IV breast cancer helps find brain involvement earlier. It may help guide treatment decisions for those who would otherwise only get brain imaging after symptoms start.
Clearwater, FloridaAges 18 years+ - NCT05539677Recruiting
Research biobank and patient registry for aggressive solid tumors
This study builds a biobank and patient registry using tumor samples and blood. It helps researchers better understand aggressive cancers and may improve future treatments by testing immune (defense) responses.
Saint PetersburgAges 1 year+ - NCT05082961Recruiting
Blood immune markers and brain radiation after head/neck surgery
This study looks at immune system signals in your blood during and after postoperative radiation therapy for certain head and neck cancers involving the brain or skull base. Researchers want to see whether these “immune markers” relate to treatment response or side effects.
CaenAges 18 years+ - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT07003542RecruitingPhase 2
Sitagliptin for people with high-grade brain tumors
This trial tests whether sitagliptin, a medicine usually used for diabetes, can help people with a fast-growing type of brain tumor (grade 4 glioma). You will take sitagliptin before your planned surgery, and researchers will study how it affects your tumor.
Cleveland, OhioAges 18 years+ - NCT07129317Recruiting
Pediatric radiation therapy registry
This study collects information from children and young adults who are getting radiation therapy to help improve future treatments. It looks at how radiation affects the body over time.
Washington D.C., District of ColumbiaAges birth–26 years - NCT07053033RecruitingPhase 2
Laser surgery or surgery plus second radiation for recurrent brain tumors
This trial is testing whether a second, precise dose of radiation to the brain, after a tumor has been removed or treated with a laser, can help people with recurrent brain metastases. It's for patients whose brain tumors have come back after prior radiation therapy.
Houston, TexasAges 18 years+ - NCT06598046RecruitingPhase 2
Utidelone and Capecitabine for triple-negative breast cancer brain metastases
This trial tests a combination of two chemotherapy drugs (Utidelone and Capecitabine) for people with triple-negative breast cancer that has spread to the brain. The goal is to see if the combination can shrink or control the brain tumors.
Zhengzhou, HenanAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT05064280RecruitingPhase 2
Pembrolizumab plus lenvatinib for brain metastases from solid tumors
This Phase 2 trial studies whether combining pembrolizumab with lenvatinib can shrink or control brain metastases in people with triple-negative breast cancer, lung cancer, or other solid tumors. It focuses on patients who have measurable brain lesions that can be followed on MRI.
Houston, TexasAges 18 years+ - NCT06248606RecruitingPhase 2
Adagrasib with brain radiation for KRAS G12C lung cancer with brain mets
This study tests a targeted pill (adagrasib) combined with focused radiation to the brain (SRS) for people with KRAS G12C-mutated lung cancer that has spread to the brain. The goal is to see if this combination can control brain tumors while treating the rest of the body.
Columbus, OhioAges 18 years+ - NCT05673928RecruitingPhase 2
Tucatinib and T-DM1 for HER2-positive brain-metastasis tumors
This Phase 2 study tests tucatinib plus T-DM1 (ado-trastuzumab emtansine) in people with HER2-positive metastatic solid tumors that have spread to the brain. It aims to shrink brain and body tumors and help control cancer that is progressing in the brain.
Houston, TexasAges 18 years+ - NCT02754544Recruiting
Brain mapping during tumor surgery while you are awake
This study uses special recording sensors during brain tumor surgery to map the brain areas that control movement and speech. It may help the surgical team protect these key functions while removing the tumor.
Houston, TexasAges 18 years+ - NCT03418961RecruitingPhase 3
Study of heart-risk management for metastatic HER2 breast cancer
This trial follows people with metastatic HER2-positive breast cancer who are at higher risk for heart damage while on HER2-targeted therapy. Some participants are randomly assigned to different monitoring/heart-protection approaches to see what best helps keep the heart safe.
Anchorage, AlaskaAges 18 years+
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Common questions
- Are there clinical trials for brain cancer?
- Yes. Clin2 currently lists 256 recruiting brain cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Gastric Cancer, Gastroesophageal Junction Cancer
- Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
- Lung Cancer Non-Small Cell Cancer (NSCLC)
- Brain Metastases From Breast Cancer
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.