Clinical trials
Chronic Kidney Disease (Stages 4 and 5) clinical trials
Below are recruiting chronic kidney disease (stages 4 and 5) clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07487727RecruitingPhase 3
Study of an experimental anemia drug for chronic kidney disease patients not on dialysis
This trial tests an oral medication (AND017) for anemia caused by chronic kidney disease. It aims to improve red blood cell levels without needing dialysis or current anemia treatments.
Beijing, Beijing MunicipalityAges 18–75 - NCT05870007Enrolling by invitationPhase 2
Atorvastatin and alkalizing treatment for autosomal dominant PKD
This Phase 2 study tests whether atorvastatin plus an “alkalizing” treatment (sodium bicarbonate) can slow or improve disease effects in people with autosomal dominant polycystic kidney disease (ADPKD). It specifically targets metabolic acidosis (when the body becomes “too acidic”), which may worsen kidney health.
New Taipei CityAges 18 years+ - NCT05514184Enrolling by invitation
Diet coaching for diabetes and kidney disease to delay dialysis
This study tests a plant-focused diet plan to help people with diabetes and moderately to severely reduced kidney function avoid or delay needing dialysis. You would get diet instructions based on your random group and have several follow-up visits and check-ins over 6 months.
Orange, CaliforniaAges 18 years+ - NCT03716401Recruiting
Imaging tests to predict kidney disease in type 2 diabetes
This study uses special kidney imaging to look for patterns that can predict how diabetic kidney disease may progress. It may help researchers find better ways to identify people at higher risk using noninvasive (and possibly biopsy-related) tests.
TurkuAges 18–80 - NCT05970341Recruiting
Healthy food program for kidney disease and better kidney health
This trial tests whether a structured “eat well” food program—focused on kidney-friendly nutrition—can help people with early to mid-stage chronic kidney disease. It may help by supporting healthier day-to-day eating over at least 6 months.
Houston, TexasAges 18 years+ - NCT07245186Enrolling by invitation
Healthy living program for kidney decline
This study tests a program to help people with chronic kidney disease (CKD) stay healthy through diet tracking and other proactive steps. It focuses on people whose kidney function has declined but who are not yet on dialysis.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT07134595Recruiting
Comparing two peritoneal dialysis schedules in children with kidney failure
This trial tests a modified version of daily peritoneal dialysis (M-CAPD) versus the standard version (C-CAPD) for children in low-resource settings who have end-stage kidney disease. It aims to see if the modified schedule works better for clearing waste and fluid.
Manila, ErmitaAges 2–18 - NCT05189925RecruitingPhase 1
Correcting a missing immune enzyme using an mRNA cell therapy
This early-phase trial tests whether an mRNA-based treatment can correct a key immune problem in people with chronic granulomatous disease (CGD). It may help your immune cells work better against infections, but this is mainly to check safety and early signs of benefit.
Bethesda, MarylandAges 18–75 - NCT07496177RecruitingPhase 2
HTD1801 for kidney function in diabetes and kidney disease
This trial tests whether a new drug, HTD1801, can protect or improve kidney function in people with type 2 diabetes and chronic kidney disease. It may help slow kidney damage and reduce protein in urine.
Weifang, ShandongAges 18–75 - NCT06749457RecruitingPhase 1/Phase 2
Study of a new drug for healthy adults and kidney patients on dialysis
This trial tests a new drug called AZD7760 in two groups: healthy adults (Phase I) and adults with end-stage kidney disease who are on hemodialysis through a central venous catheter (Phase IIa). The goal is to see how safe the drug is and how the body processes it. This could lead to a new treatment option for people on dialysis.
Huntsville, AlabamaAges 18–55 - NCT07182942RecruitingPhase 4
Study of Xiqing and Probiotics for Chronic Kidney Disease
This trial tests if taking Xiqing (a Chinese herbal product) and probiotics together can help people with chronic kidney disease (CKD) by improving gut health and making their medication work better. It is for patients with moderate to advanced CKD who do not need dialysis yet.
Wuhan, HubeiAges 18–75 - NCT04500665RecruitingPhase 2
Colchicine for kidney-related heart inflammation
This Phase 2 trial tests whether colchicine can reduce inflammation and improve heart function in people with kidney disease and a certain type of heart problem. If you qualify, you’ll be closely monitored for side effects and lab changes.
Boston, MassachusettsAges 21–80 - NCT04759274Recruiting
Personalized water pill dosing support for kidney and fluid overload
This trial tests a decision-support tool to help your care team safely adjust water pills (“diuretics”) when you have kidney disease and fluid buildup. It may help reduce swelling by guiding dosing using your home weight and blood pressure.
Dallas, TexasAges 18 years+ - NCT05321368Recruiting
Program to help control blood pressure and support health equity
This study tests a program that combines clinic care, community support, and phone-based monitoring to help people better manage blood pressure and related health problems. It aims to reduce health differences between groups that have been affected more by preventable disease.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05880914Recruiting
Personalized treatment study for bone disease in kidney failure
This trial looks at a personalized approach to diagnosing and treating bone problems caused by long-term kidney disease. It may help by matching treatment plans to the type of bone turnover found in your tests or biopsy.
St Louis, MissouriAges 18 years+ - NCT06128278RecruitingPhase 2
Equol supplement and blood vessel health in women
This study tests whether taking an Equol supplement (a soy-related compound) improves blood vessel function in postmenopausal women with and without chronic kidney disease (CKD). It could help women with or without early-stage CKD learn if this supplement supports heart health.
Aurora, ColoradoAges 50–69 - NCT06278207Recruiting
Finerenone in real-world diabetes and kidney disease
This study looks at how the medication finerenone works in everyday medical practice for people with type 2 diabetes and certain stages of chronic kidney disease. It aims to see how safe and effective the treatment is outside of a clinical trial setting.
Multiple Locations, New JerseyAges 18 years+ - NCT06310967RecruitingPhase 1/Phase 2
Study of IG3018 for high uric acid with or without kidney disease
This trial tests a new medicine, IG3018, to lower high uric acid levels in people with or without chronic kidney disease. It aims to find the right dose and see if it's safe.
Botany, New South WalesAges 18–75 - NCT07694544RecruitingPhase 1
Oral EC5026 study in people with kidney disease
This trial tests a medication called EC5026 in people with and without chronic kidney disease (CKD) to see how the body handles it. It helps understand if dose adjustments are needed for people with impaired kidney function.
Sacramento, CaliforniaAges 55 years+ - NCT06624358Recruiting
Physical activity study for teens with chronic kidney disease
This study looks at physical activity in teens with chronic kidney disease (CKD) who are not yet on dialysis or have had a transplant. It aims to understand their current activity levels and how to help them stay active safely.
Philadelphia, PennsylvaniaAges 13–18 - NCT06656988RecruitingPhase 3
Saving kidney function during leg artery treatment with carbon dioxide
This trial tests if using carbon dioxide gas instead of standard dye during a leg artery procedure can protect the kidneys. It is for people with blocked leg arteries who also have reduced kidney function.
InnsbruckAges 18 years+ - NCT05159466Recruiting
Transplant from HIV-positive donors to HIV-positive recipients
This trial studies whether it’s safe and effective for HIV-positive people to receive organ transplants from HIV-positive donors. It focuses on matching HIV treatment before and after transplant and checking for major complications.
Metairie, LouisianaAges 18 years+ - NCT06878560RecruitingPhase 1/Phase 2
Pig kidney transplant for kidney failure patients
This trial tests a special pig kidney (10 GE Xenokidney) as a transplant option for people with kidney failure who cannot get a human kidney. It aims to offer a life-saving alternative.
Chicago, IllinoisAges 40–70 - NCT07224763RecruitingPhase 1/Phase 2
Pig kidney transplant trial for kidney failure patients
This trial tests a genetically modified pig kidney (Thymokidney) for people with end-stage kidney disease who are on dialysis. It aims to see if this new type of transplant is safe and effective for those who cannot get a human kidney.
New York, New YorkAges 40–70
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Common questions
- Are there clinical trials for chronic kidney disease (stages 4 and 5)?
- Yes. Clin2 currently lists 112 recruiting chronic kidney disease (stages 4 and 5) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic kidney disease (stages 4 and 5) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic kidney disease (stages 4 and 5) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.