Clinical trials
Chronic Kidney Disease (Stages 4 and 5) clinical trials
Below are recruiting chronic kidney disease (stages 4 and 5) clinical trials, each written for real people, not researchers. We’re tracking 112 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06283966RecruitingPhase 3
Triple inhaler for COPD with heart risk
This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) to see if it can help protect the heart and lungs in people with COPD who also have heart problems or high risk for them.
Athens, AlabamaAges 40–80 - NCT04037995Recruiting
Real-world study of advanced liver disease in China
This study looks at people with very advanced liver problems to better understand what happens in real life. It may help doctors improve care for advanced cirrhosis and certain liver cancers.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07352800RecruitingPhase 2
Study of APAC for peripheral artery disease and severe leg ischemia
This trial tests a new drug called APAC to see if it safely prevents blood clots and improves blood flow in people with narrowed leg arteries. It may help those with severe symptoms like pain at rest or non-healing wounds, or those with claudication (leg pain when walking).
HelsinkiAges Up to 85 years - NCT07630545RecruitingPhase 1
Testing a new drug for Parkinson's disease
This study tests an experimental drug, MTX325, in people with Parkinson's disease. The goal is to see if it is safe and how the body processes it, which may lead to new treatment options.
AdelaideAges 18–75 - NCT06491043RecruitingPhase 2
Stem cells for COPD: safety and early effectiveness study
This trial tests whether an infusion of donor stem cells can help people with moderate to severe COPD breathe easier. If you are a current or former smoker aged 40 to 80, your symptoms are stable, and your lung function meets specific targets, you may be able to join.
New Taipei CityAges 40–80 - NCT07492511Recruiting
Ultrasound patterns in kidney and liver after trauma
This trial uses special ultrasound (Doppler) to look at blood flow in the kidneys and liver after a serious injury. It aims to find patterns that could help doctors better understand and treat trauma patients.
BolognaAges 18–65 - NCT06056102RecruitingPhase 1
CAR-T cell therapy to help highly sensitized kidney transplant patients
This trial tests whether a special immune cell treatment (CAR-T cells) can lower the antibodies that make it very hard for you to receive a kidney transplant. If it works, you might become eligible for a transplant sooner.
Boston, MassachusettsAges 18–65 - NCT06842966RecruitingPhase 2
Testing a new tablet for chronic gallbladder issues
This trial tests an investigational tablet for people with long-term gallbladder inflammation (chronic cholecystitis) or bile duct movement problems (biliary dyskinesia). It aims to see if the tablet reduces stomach pain and other digestive symptoms.
Engel'sAges 18–70 - NCT06850597RecruitingPhase 2
Testing dimethyl fumarate for early Alzheimer's disease
This study tests a drug called dimethyl fumarate to see if it can help people with early Alzheimer's disease. It may slow down memory loss and thinking problems.
Lodz, Łódź VoivodeshipAges 55–90 - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT07595003RecruitingPhase 3
Testing a new medicine for gallbladder pain and discomfort
This study tests whether a medicine called 4-MUST can safely reduce pain and digestive symptoms caused by chronic gallbladder problems. You'll take tablets for several weeks while researchers track how well the medicine works and any side effects.
MoscowAges 18–70 - NCT06483074RecruitingPhase 2
Empagliflozin to preserve kidney function in new peritoneal dialysis patients
This trial tests whether empagliflozin, a medication originally for diabetes, can help protect the remaining kidney function in people who have just started peritoneal dialysis. If you started dialysis within the last 3 months and still make some urine, this study may be a good fit.
Hong KongAges 18–75 - NCT07672977Enrolling by invitation
Sound therapy at home to improve deep sleep in early Alzheimer's
This study tests whether a wearable device that plays soft sounds during sleep can boost deep sleep brain waves in people with mild memory problems caused by Alzheimer's. It aims to see if this simple, home-based approach can help protect memory and thinking.
Zaragoza, ZaragozaAges 50–75 - NCT00977977RecruitingPhase 2
Rituximab plus cyclosporine for membranous kidney disease
This trial tests whether rituximab (an immune-targeting medicine) plus cyclosporine (another immune medicine) can better control protein leakage in the urine for people with idiopathic membranous nephropathy. It may help reduce long-lasting kidney damage risk when standard treatments like ACE inhibitor or ARB don’t control the protein level.
Bethesda, MarylandAges 18–90 - NCT04981509RecruitingPhase 2
Check if 3 medicines help advanced kidney cancer
This Phase 2 trial tests whether combining bevacizumab, erlotinib, and atezolizumab can shrink or control advanced kidney cancer. It’s aimed at people with certain kidney-cancer subtypes (including HLRCC-related cases or papillary kidney cancer) and who have not had many prior targeted or immune treatments.
La Jolla, CaliforniaAges 12 years+ - NCT06399419RecruitingPhase 1
Study of CBM588 with immunotherapy for advanced kidney cancer
This trial tests whether adding a probiotic (CBM588) to a standard immunotherapy combination (nivolumab and ipilimumab) helps treat advanced kidney cancer. It is for people with a specific type of kidney cancer that has spread or cannot be removed with surgery, who have not had systemic treatment before.
Duarte, CaliforniaAges 18 years+ - NCT05832229RecruitingPhase 2
Studying rosuvastatin to slow liver scarring in cirrhosis
This Phase 2 trial tests whether rosuvastatin (a cholesterol-lowering medicine) can improve how well the liver functions and slow worsening scarring in people with cirrhosis. It also checks for side effects and safety.
La Jolla, CaliforniaAges 18–75 - NCT06071429Recruiting
Dissolvable medicine stent for leg artery disease
This trial tests a new dissolvable stent that slowly releases medicine to keep your lower-leg artery open. It is for people with severe leg pain or small wounds due to poor blood flow, and who are not eligible for other stents.
New York, New YorkAges 18 years+ - NCT06291077RecruitingPhase 4
Belatacept vs anticalcineurins after kidney transplant
This study is comparing two medications after kidney transplant: Belatacept and anticalcineurins (like tacrolimus). It looks at how each affects blood vessel health. If you are more than a year post-transplant and have stable kidney function, you may be eligible.
RouenAges 18–75 - NCT07142252RecruitingPhase 2
New drug for recently diagnosed type 1 diabetes
This trial tests a new medicine (rezpegaldesleukin) to see if it can help preserve the body's ability to make some insulin in people recently diagnosed with type 1 diabetes. It's for children and adults diagnosed within the past 100 days.
Aurora, ColoradoAges 8–45 - NCT06708338Recruiting
Bevel direction during dialysis fistula puncture
This study looks at which way the needle bevel should face when starting dialysis through a new fistula. It might help reduce pain or damage to the fistula.
Le Puy-en-VelayAges 18–85 - NCT06173947Recruiting
SSM Score for Liver Injury in Chronic Liver Disease
This study looks at how well a simple score (called SSM) can predict recovery in people with chronic liver disease who suddenly get a liver injury with jaundice. It may help your doctors understand how serious your condition is.
Guangzhou, GuangdongAges 18–80 - NCT06597201RecruitingPhase 4
Testing Amino Acid Dialysis Solution for Malnutrition on Peritoneal Dialysis
This trial tests a special peritoneal dialysis solution with amino acids (protein building blocks) to improve nutrition in people on CAPD who are malnourished. It might help boost your protein levels and overall health.
Hefei, AnhuiAges 18–75 - NCT06772454Recruiting
Testing a new drug combo for advanced lung cancer with COPD
This trial tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and inhaled steroids helps people with advanced lung cancer who also have COPD. The goal is to see if this combination improves outcomes.
Guangzhou, GuangdongAges 18 years+
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Common questions
- Are there clinical trials for chronic kidney disease (stages 4 and 5)?
- Yes. Clin2 currently lists 112 recruiting chronic kidney disease (stages 4 and 5) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic kidney disease (stages 4 and 5) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic kidney disease (stages 4 and 5) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.