Clinical trials
Chronic Pain Syndrome clinical trials
Below are recruiting chronic pain syndrome clinical trials, each written for real people, not researchers. We’re tracking 218 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07734051Enrolling by invitation
Mobilization for kneecap pain
This trial tests if adding a groin-area mobilization to foot mobilization helps with kneecap (patellofemoral) pain. It may be for you if you have one-sided kneecap pain for at least 3 months, especially when climbing stairs, squatting, or sitting for long periods.
Fāqūs, SharkeyaAges 18–40 - NCT07429773Recruiting
Immune markers in stubborn pelvic pain
This study looks at the immune system's response in people with chronic pelvic pain that hasn't gotten better with first treatments. By measuring certain immune markers, the researchers hope to better understand why the pain persists and find new ways to help.
Nice, Alpes-MaritimesAges 18–40 - NCT06973837Recruiting
Brain study on chronic back pain and insomnia
This study looks at how the brain works in people with chronic low back pain and/or chronic insomnia. It compares these groups to healthy volunteers using MRI and pain tests.
LeuvenAges 18–60 - NCT06963658Recruiting
Isometric Exercise and Pain Sensitivity in Chronic Low Back Pain
This study tests whether a simple, still (isometric) exercise can reduce how sensitive you are to pain. It is for adults with long-term low back pain who can safely do physical therapy exercises.
Bisha, 'Asir RegionAges 18 years+ - NCT06004804Recruiting
Psychological treatments for chronic pain in veterans
This study compares two group psychological treatments for chronic pain delivered over video conference. It aims to see if these treatments help reduce pain and improve quality of life for veterans.
West Los Angeles, CaliforniaAges 60–95 - NCT05701852Recruiting
Study brain scans during tasks in chronic nerve pain
This study looks at how brain activity changes in people with long-lasting nerve pain using an MRI scan while you do simple behavioral tasks. It may help researchers understand brain function in chronic neuropathic pain and how it affects day-to-day abilities.
ParisAges 18 years+ - NCT05780450Recruiting
Brain stimulation for long covid headaches and pain
This trial tests a safe, non-invasive brain stimulation technique (transcranial direct current stimulation, or tDCS) to see if it can reduce persistent headaches and chronic pain in people with long covid. If you have ongoing pain after a confirmed covid infection, this could offer a new way to find relief.
Paiporta, ValenciaAges 16 years+ - NCT07469345Enrolling by invitation
Teeth Grinding and Pelvic Pain in Young Men
This study looks at how teeth grinding (bruxism) is linked to pelvic pain, erectile function, and anxiety in young adult men. It aims to understand if these issues are connected, which could help develop better treatments.
KonyaAges 18–30 - NCT06102733Recruiting
Pelvic pain study for women and men
This trial is testing treatments for chronic pelvic pain, sacroiliac pain, groin pain, tailbone pain, and piriformis pain. It may help people with persistent pain in these areas find relief.
Surrey, British ColumbiaAges 20–99 - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT06261866Recruiting
Heart imaging for moderate blockages in stable heart disease
This trial tests whether combining two advanced imaging tests (FFR and OCT) can help doctors better decide treatment for moderate blockages in heart arteries. If you have stable chest pain or a positive stress test and a moderate narrowing, this study may help guide your care.
WarsawAges 18 years+ - NCT07749066Recruiting
Laser treatment for hip pain
This study tests a high-intensity laser treatment to reduce hip pain and improve function in people with greater trochanteric pain syndrome (pain on the outside of the hip). It may help if you've had hip pain for at least 3 months and haven't had recent injections or other conservative treatments.
Ankara, YenimahalleAges 18–80 - NCT07334561Recruiting
Brain stimulation for depression and pain
This study tests a non-invasive brain stimulation treatment (transcranial electrical stimulation) for people who have both depression and chronic pain. It aims to see if this treatment can help improve mood and reduce pain.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07038434Recruiting
Using artificial intelligence to measure pain in chronic pain patients
This study uses artificial intelligence to better understand and measure pain in people with chronic pain. The goal is to develop smarter ways to assess pain automatically, which could lead to better treatment.
Salerno, ItalyAges 18 years+ - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT03168802Recruiting
Ultrasound and nerve treatment for facet-joint low back pain
This study tests whether a procedure that uses focused ultrasound (MRgFUS) and/or a radiofrequency nerve treatment can reduce long-lasting low back pain caused by facet-joint arthritis. It may help people whose pain improves strongly after a targeted numbing injection to specific back nerves.
Taipei, Please SelectAges 20–79 - NCT05277025Recruiting
Brain pain testing in long-term joint pain and fibromyalgia
This study looks at how the brain processes pain in people with long-term pain conditions like fibromyalgia and rheumatoid arthritis. You may be asked to undergo pain-related tasks to help researchers understand differences between inflammatory and non-inflammatory chronic pain.
Gainesville, FloridaAges 18–70 - NCT04144972Recruiting
Closed-loop deep brain stimulation for long-lasting nerve pain
This trial tests a “smart” deep brain stimulation device that senses your brain signals and adjusts treatment to reduce severe, long-lasting pain. It may help people whose pain has not improved with multiple pain medicines and surgery cannot fix the cause.
San Francisco, CaliforniaAges 22–80 - NCT07436806Recruiting
Comparing nerve blocks for pain after chest surgery
This trial compares two types of nerve blocks to see which one better prevents long-term pain after video-assisted chest surgery. It may help find a way to reduce chronic pain after your procedure.
Istanbul, BagcilarAges 18–75 - NCT06908200Recruiting
Radiofrequency for chronic pelvic pain with myofascial syndrome
This trial compares radiofrequency treatment, myofascial therapy, and no treatment to see which is most effective for women with chronic pelvic pain caused by tight or tender pelvic floor muscles. It aims to help reduce pain and improve quality of life.
BarcelonaAges 18 years+ - NCT07199361Recruiting
Magnetic stimulation for chronic pain after injury or surgery
This study tests a non-invasive magnetic device placed on the skin to see how it relieves chronic pain caused by a past injury or surgery. It may help people who have had pain for at least three months and take medication for it.
Miami, FloridaAges 19–80 - NCT06052384Recruiting
Better sleep care for chronic pain patients
This study tests whether adding a sleep specialist to your pain care team can help you feel better. If you have chronic pain (lasting over 3 months) and are now seeing a pain doctor for the first time, you may be able to join.
Le Puy-en-VelayAges 18 years+ - NCT07525063Enrolling by invitation
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation technique (called TMS) can help reduce pain and improve mood in women with fibromyalgia. Researchers will use MRI scans and brain stimulation to understand how pain and reward circuits in the brain work.
Durham, North CarolinaAges 18 years+
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Common questions
- Are there clinical trials for chronic pain syndrome?
- Yes. Clin2 currently lists 218 recruiting chronic pain syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.