Clinical trials
Chronic Postoperative Pain clinical trials
Below are recruiting chronic postoperative pain clinical trials, each written for real people, not researchers. We’re tracking 296 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07200544RecruitingPhase 4
Meloxicam for skin cancer surgery pain
This study tests if meloxicam, an anti-inflammatory painkiller, helps control pain after Mohs surgery for skin cancer. It aims to reduce the need for stronger opioid pain medicines.
Oklahoma City, OklahomaAges 18–110 - NCT07188779RecruitingPhase 2
Impact of a special gel on tonsillectomy recovery in children
This trial tests whether applying a special gel called RADA16 to the surgical site after tonsillectomy (removal of tonsils) can help children heal better and with less pain. It may offer a new way to improve recovery after this common surgery.
Livingston, New JerseyAges 3–17 - NCT06679569Recruiting
Deep muscle relaxants for less pain after children's belly-button surgery
This study looks at whether giving a deep muscle relaxant during your child's belly-button surgery can reduce pain after the operation. It may help kids feel better and recover more comfortably.
Seoul, SeoulAges 2 months–7 years - NCT07090928RecruitingPhase 4
Numbing medicine for less pain after knee scope surgery
This study tests whether giving bupivacaine (a numbing medicine) around the time of knee arthroscopy can reduce pain at the surgery sites and help you move your knee better after the operation.
Peshawar, KPKAges 18–70 - NCT07060495RecruitingPhase 3
RADA16 gel for pain after adult tonsillectomy
This trial tests a new gel (RADA16) placed on the tonsil area after surgery to see if it helps reduce pain and speed healing. It is for adults having a standard tonsillectomy.
Livingston, New JerseyAges 18 years+ - NCT07037888RecruitingPhase 4
Ketorolac for pain after hip arthroscopy
This study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), helps manage pain after hip surgery. It may offer an opioid-sparing option for patients with femoroacetabular impingement (FAI).
Detroit, MichiganAges 18–89 - NCT07004634Recruiting
Comparing Drain Types After Minimally Invasive Esophageal Cancer Surgery
This study compares two different ways of placing drains after minimally invasive surgery for esophageal cancer. It aims to find which method helps you recover better and with fewer complications.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06479122RecruitingPhase 4
Pain relief after C-section: acetaminophen with or without ibuprofen
This study compares two common pain relievers after C-section: acetaminophen alone versus acetaminophen plus ibuprofen. It aims to see if the combination offers better pain control after childbirth.
SeoulAges 19 years+ - NCT06976320Recruiting
Nerve block for gallbladder surgery pain
This trial tests a nerve block injection in the abdominal wall to reduce pain after gallbladder removal surgery. It may help patients recover more comfortably.
IstanbulAges 18–80 - NCT06964282Recruiting
Comparing Two Nerve Blocks for Hip Replacement Pain Relief
This study compares two types of nerve blocks (iliopsoas block and PENG block) to see which one provides better pain relief and recovery after hip replacement surgery. If you are having a hip replacement with spinal anesthesia, you may be a good candidate.
LiègeAges 18 years+ - NCT06960018Recruiting
Ennovate minimally invasive spinal screw placement study
This study tests a new, less invasive method for placing screws in the cervical spine (upper back and neck). It is designed for patients who need spinal stabilization after injury or degeneration.
AachenAges 18 years+ - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT06931743Recruiting
Electrical stimulation for pain after thyroid surgery
This trial tests if electrical stimulation can help reduce pain after thyroid surgery. It is for people who have at least moderate pain after their operation.
Shanghai, Changning DistrictAges 18 years+ - NCT06640231Recruiting
Sealer activation for reducing pain after root canal
This trial tests if activating a sealer inside a tooth after root canal can reduce pain in the days after treatment. It may help people with a painful lower molar that still has a live nerve.
Cairo, New CairoAges 18–40 - NCT06837909Recruiting
Nerve block vs wound injection for breathing after kidney donation
This study compares two ways to manage pain after laparoscopic kidney donation surgery: a nerve block (injection near the belly muscles) versus injecting numbing medicine directly into the surgical wound. The goal is to see which method helps you breathe better after surgery.
Petah TikvaAges 18 years+ - NCT06740214RecruitingPhase 3
Different doses of liposomal bupivacaine for knee replacement pain
This trial tests different doses of a long-acting painkiller (liposomal bupivacaine) injected into a nerve block in the thigh to see which dose works best for pain after knee replacement surgery. It may help you have better pain control and recover faster.
Hong Kong, Hong KongAges 18–80 - NCT06745388RecruitingPhase 4
Magnesium for cramping during hysteroscopy or D&C
This study tests whether magnesium can reduce cramping during a hysteroscopy or D&C. If you are having one of these procedures and are not on certain medications, you may qualify.
Royal Oak, MichiganAges 18 years+ - NCT06664177Recruiting
Pain block comparison for hernia surgery
This trial compares two nerve-block techniques (Quadratus Lumborum block vs. Transversalis Fascia block) to control pain after inguinal hernia surgery. It aims to find which method provides better pain relief and recovery.
IstanbulAges 18–65 - NCT06576830RecruitingPhase 4
Pain relief study for kids having tonsil surgery
This study tests different ways to manage pain after tonsillectomy in children. The goal is to find better pain relief options.
Durham, North CarolinaAges 3–17 - NCT06525740RecruitingPhase 4
Comparing two pain medicines for gynecologic cancer surgery
This trial compares two different pain medicines (methadone given by mouth or IV vs. hydromorphone given through a spinal injection) after surgery for gynecologic cancer. It aims to find which option provides better pain relief with fewer side effects.
Rochester, MinnesotaAges Any age - NCT06384456RecruitingPhase 4
TXA vs Placebo for Pain After Wrist Surgery
This study tests if tranexamic acid (TXA), a medicine used to reduce bleeding, can help lessen pain right after wrist fracture surgery. You may be able to join if you had breast cancer and radiation at least a year ago, are not currently on active cancer treatment, and don't take blood thinners or daily strong pain pills.
Toronto, OntarioAges 18 years+ - NCT06324942Recruiting
Nerve block for C-section pain relief
This study tests whether an extra nerve block (called a TAP block) given by your surgeon during a planned C-section can provide better pain relief than standard care alone. Researchers want to see if it reduces the need for stronger pain medicines after delivery.
Calgary, AlbertaAges 18 years+ - NCT06067893Enrolling by invitationPhase 2
Low dose sedation medicine for pain after scoliosis surgery
This trial tests a low dose of a sedative medicine, dexmedetomidine, given during and after spine surgery to see if it helps with pain. It is for teens and adults with scoliosis having back fusion surgery.
Kansas City, MissouriAges 10–21 - NCT04219956Recruiting
Low-sugar diet aims to reduce belly-surgery pain
This study tests whether a special diet low in polyamines (a food-related substance) can reduce pain after major abdominal surgery. It compares pain control while you use a patient-controlled morphine pump or take opioid tablets by mouth after surgery.
BrestAges 18 years+
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Common questions
- Are there clinical trials for chronic postoperative pain?
- Yes. Clin2 currently lists 296 recruiting chronic postoperative pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic postoperative pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic postoperative pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Postoperative Pain
- Postoperative Pain, Acute
- Postoperative Pain Management
- Total Knee Arthroplasty (Postoperative Pain)
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
- Postoperative Pain After Endodontic Treatment
- Postoperative Pain Following Knee Arthroplasty
- Postoperative Pain Management in Oral Surgery
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.