Clinical trials
Clinical High Risk clinical trials
Below are recruiting clinical high risk clinical trials, each written for real people, not researchers. We’re tracking 555 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06726642Recruiting
Blood test study for people with inherited cancer risk
This study looks for DNA fragments in blood of people with certain inherited cancer syndromes. It may help find cancer earlier or guide better monitoring. You would give blood samples every 4 months (if in the experimental group).
Vancouver, British ColumbiaAges Up to 90 years - NCT06735690RecruitingEarly Phase 1
Immune cells plus vaccine after stem cell transplant for leukemia
This trial is for people with high-risk acute lymphoblastic leukemia who are getting a stem cell transplant from a family donor. After transplant, you'd receive a treatment that combines specially designed immune cells (CAR T cells) that target your leukemia, plus a vaccine that helps those cells work better.
Duarte, CaliforniaAges 18 years+ - NCT06797635RecruitingPhase 2
Study of Patritumab Deruxtecan and Pembrolizumab for High-Risk Early Breast Cancer
This trial tests a combination of targeted therapies (patritumab deruxtecan plus pembrolizumab) along with other anticancer drugs for people with a high-risk type of early-stage breast cancer that is either triple-negative or has very low hormone receptors and is HER2-negative. The goal is to see if this approach can help prevent the cancer from coming back.
Santa Monica, CaliforniaAges 18 years+ - NCT06802146RecruitingEarly Phase 1
Early treatment for high-risk CCUS
This trial tests an early treatment for people with a condition called high-risk CCUS, where low blood counts and gene changes raise the risk of developing blood cancer. The goal is to see if intervening early can prevent or delay progression to leukemia or MDS.
Boston, MassachusettsAges 18 years+ - NCT06810791RecruitingPhase 3
Comparing Chemotherapy Combos for High-Risk AML
This trial compares three chemotherapy combinations (HVA vs IA/DA or VA) for people with newly diagnosed high-risk acute myeloid leukemia (AML). It aims to find which treatment works better.
Guangzhou, GuangdongAges 18 years+ - NCT06819566RecruitingPhase 2
Preventing bleeding from enlarged veins in the esophagus
This study tests whether tying off high-risk veins in the esophagus before starting a common liver cancer treatment can prevent bleeding. It is for people with liver cancer that has spread but who have never had cancer treatment before.
Seoul, Song-paAges 19–80 - NCT06848582Recruiting
NK cell therapy for high-risk pediatric soft tissue sarcoma
This trial tests whether giving immune cells called NK cells from donated umbilical cord blood can help children and teens with high-risk or returning soft tissue sarcoma. The goal is to see if it is safe and effective when other treatments have been tried.
Guangzhou, GuangdongAges Up to 18 years - NCT06897839RecruitingPhase 2/Phase 3
Testing zelpultide alfa for preterm babies at risk of lung disease
This trial tests a medicine called zelpultide alfa in very premature babies who are at high risk of developing bronchopulmonary dysplasia (BPD), a chronic lung disease. The goal is to see if it can help prevent or lessen lung problems compared to standard care alone.
Buenos AiresAges birth–4 days - NCT06910956Recruiting
Finding high-risk patients for lung cancer screening using chest X-rays
This trial uses artificial intelligence to analyze chest X-rays and identify people who may be at high risk for lung cancer and could benefit from a CT screening scan. It's designed for current or former smokers aged 50 to 77 who have had a recent chest X-ray and are not already being checked for lung cancer.
Boston, MassachusettsAges 50–77 - NCT06918431RecruitingPhase 2
Erwinia asparaginase with chemo for new ALL or LBL
This trial tests adding an asparaginase drug to standard chemotherapy for adults with newly diagnosed acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL). The goal is to see if this combination improves outcomes.
Phoenix, ArizonaAges 18–54 - NCT06923345RecruitingPhase 2
Modified long-course radiation and chemo with immunotherapy for rectal cancer
This trial tests a treatment plan involving radiation, chemotherapy, and an immunotherapy drug (a PD-1 inhibitor) for people with a specific type of high-risk rectal cancer. The goal is to see if this combination helps shrink the tumor before surgery.
Guangzhou, GuangdongAges 18–75 - NCT06928662RecruitingPhase 1/Phase 2
Chemo, radiation, and donor stem cell transplant for high-risk blood cancers
This trial tests a strong chemotherapy and radiation combo followed by a donor stem cell transplant for people with aggressive blood cancers (like AML or MDS) that haven't responded to earlier treatments or came back. It aims to help prevent the cancer from returning.
Seattle, WashingtonAges 18 years+ - NCT06932250Recruiting
Leg heating for weight and blood pressure in pregnancy
This trial tests if applying heat to the legs can improve blood vessel function in pregnant women with overweight or obesity. It may help manage blood pressure and reduce risks of pregnancy complications.
Dallas, TexasAges 18–45 - NCT06932757RecruitingPhase 2
Quisinostat after treatment for high-risk uveal melanoma
This trial tests whether taking quisinostat pills after standard treatment can lower the chance of uveal melanoma coming back in people whose original tumor had high-risk features. It is for patients who have finished their eye treatment (surgery or radiation) within the past 6 months and have no signs that the cancer has spread.
Miami, FloridaAges 19 years+ - NCT06959316Recruiting
T1D Pregnancy & Me
This study tests how well continuous glucose monitors (CGMs) help manage type 1 diabetes during pregnancy. If you are pregnant, have type 1 diabetes, and regularly use a CGM, this trial may help you track your blood sugar and improve your baby's health.
Birmingham, AlabamaAges 18 years+ - NCT06967038RecruitingPhase 1/Phase 2
Natural killer cell therapy for high-risk lymphoma with Sjogren's syndrome
This trial tests a new type of immune cell therapy using natural killer cells to treat people who have both high-risk lymphoma and primary Sjogren's syndrome. The goal is to see if these cells can safely and effectively fight the lymphoma while managing the autoimmune condition.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06977711RecruitingPhase 1
Testing a new drug combo for high-risk DLBCL
This trial is testing a new combination of drugs for people with a high-risk type of lymphoma called DLBCL who have not been treated before. It adds loncastuximab and roflumilast to the standard R-CHOP therapy to see if it works better at fighting the cancer.
San Antonio, TexasAges 18 years+ - NCT06990321RecruitingPhase 3
Cytarabine and venetoclax for older adults with AML
This trial tests a combination of two chemotherapy drugs, medium-dose cytarabine and venetoclax, as a follow-up treatment (consolidation) to keep leukemia from coming back. It is for older adults with intermediate or high-risk acute myeloid leukemia who have already achieved remission after their first round of therapy.
Changchun, JilinAges 60–75 - NCT06994416Recruiting
New fluorescent needle for finding breast lesions
This trial tests a special needle that glows to help surgeons find and remove high-risk breast lesions. If you've already had a breast lesion found by ductoscopy and a duct excision, you might be able to join.
Shenyang, LiaoningAges 18–75 - NCT06994676RecruitingPhase 1
Study of CBX-250 for advanced myeloid leukemias
This study tests an experimental drug, CBX-250, for people with certain advanced blood cancers (like AML) that have not responded to standard treatments or have returned. The drug works only for people who have a specific genetic marker (HLA-A*02:01). The goal is to see if it is safe and how well it works.
Duarte, CaliforniaAges 12 years+ - NCT07009418Recruiting
CT scan vs. usual care after heart stent or balloon treatment
This trial tests whether a CT scan of the heart arteries is a safe and effective alternative to standard follow-up tests in people who have had a stent or drug-coated balloon placed in a high-risk coronary artery. It may help reduce the need for additional invasive procedures.
Bucheon-siAges 19 years+ - NCT07019363RecruitingPhase 3
CDK4/6 inhibitor plus hormone therapy for high-risk breast cancer
This trial tests whether adding a CDK4/6 inhibitor (a type of targeted pill) to standard hormone therapy after surgery can lower the risk of breast cancer coming back in women with high-risk, hormone-receptor-positive, HER2-positive early breast cancer.
ShanghaiAges 18–70 - NCT07019623Recruiting
U-CaVIT device vs standard care for preventing heavy bleeding after c-section
This study tests a new device called U-CaVIT to prevent heavy bleeding after a planned cesarean delivery in women at high risk. It compares the U-CaVIT device to standard care to see which works better.
ZurichAges 18 years+ - NCT07036731Recruiting
Urine test study for second bladder surgery
This trial compares the need for a second surgery for people with early-stage bladder cancer. It uses a simple urine test to see if the test can help decide whether a second operation is necessary, which could save some patients from an extra procedure.
Nanjing, JiangsuAges 18–80
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Common questions
- Are there clinical trials for clinical high risk?
- Yes. Clin2 currently lists 555 recruiting clinical high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clinical high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clinical high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.