Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 898 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06856837RecruitingPhase 2
Fruquintinib and Tislelizumab for advanced colorectal cancer
This trial tests a combination of two drugs, fruquintinib and tislelizumab, for people with a specific type of advanced colorectal cancer that has not spread to the liver. It is for those whose cancer is stable in certain DNA repair systems (MSS/pMMR) and who have already tried other treatments.
LinzAges 18 years+ - NCT06903858RecruitingPhase 2
Toripalimab plus celecoxib for dMMR/MSI-H colorectal cancer
This trial tests whether combining toripalimab (an immunotherapy) with celecoxib (an anti-inflammatory drug) can shrink locally advanced colorectal tumors that have specific genetic features (dMMR or MSI-H). It aims to help people who haven't had any prior treatment for their colorectal cancer.
Guangzhou, GuangdongAges 18 years+ - NCT06914245Recruiting
Personalized help for bowel symptoms after rectal cancer treatment
This trial studies how to improve bowel symptoms in people treated for rectal cancer. It tests personalized care plans and looks at different factors that may contribute to bowel problems after surgery or a watch-and-wait approach.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06940388RecruitingPhase 2
Immunotherapy plus standard treatment for rectal cancer
This trial is testing whether adding the immunotherapy drug tislelizumab to standard total neoadjuvant treatment (chemotherapy and radiation before surgery) can improve outcomes for people with locally advanced rectal cancer. The goal is to see if the combination helps shrink the tumor more than standard treatment alone.
MainzAges 18 years+ - NCT06949098RecruitingPhase 2
Local tumor removal plus chemo-radiation for early low rectal cancer
This trial tests whether removing just the tumor locally, followed by chemotherapy and radiation, is effective for early-stage (T1-2 N0) rectal cancers located low or very low in the rectum. It may help you keep your anal opening and avoid major surgery that requires a permanent colostomy bag.
Shijiazhuang, HebeiAges 18–75 - NCT06958419RecruitingPhase 2/Phase 3
Short radiation plus targeted drugs for advanced colon cancer
This trial tests a combination of short-course radiation, chemotherapy, targeted therapy (bevacizumab), and an immunotherapy drug (PD-1 inhibitor) for people with advanced colorectal cancer that has spread and is not curable with surgery. It aims to see if this approach can help shrink tumors and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06958432RecruitingPhase 2/Phase 3
Short-course radiation plus chemo and immunotherapy for rectal cancer
This trial tests a treatment plan that uses a short course of radiation to the lymph nodes-sparing area, followed by chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of mid or low rectal cancer (pMMR/MSS). The goal is to see if this approach can shrink the tumor and improve outcomes without needing extensive surgery.
Guangzhou, GuangdongAges 18–75 - NCT07024225Recruiting
A look back at colon and rectal cancers
This study reviews medical records of people with colon or rectal cancer to better understand the disease. It helps researchers learn more without any new treatments or procedures.
Sohag, Sohag GovernmentAges 18–80 - NCT07068763RecruitingPhase 2
Short radiation plus drugs for early rectal cancer
This trial tests a combination of short-course radiation, chemotherapy (capecitabine), and two immunotherapy drugs (PD-1 and CTLA-4 inhibitors) for people with early-stage rectal cancer who want to avoid surgery and keep their anus. The goal is to see if this treatment can shrink the tumor enough to avoid major surgery.
Hangzhou, ZhejiangAges 18–80 - NCT07070622RecruitingPhase 3
Organ preservation for low rectal cancer after chemo
This trial tests whether chemotherapy alone can help avoid surgery for low rectal cancer. It is for people with tumors close to the anus that haven't spread far, and who haven't had prior cancer treatment.
Chengdu, SichuanAges 18–80 - NCT07087561Recruiting
Nutrition and health education after colorectal cancer surgery
This trial tests whether a short-term nutritional supplement combined with health education can improve recovery after surgery for colorectal cancer. It is for people with stage IIa, IIb, or IIIa colon or rectal cancer who have completed surgery and are able to engage in follow-up.
Xi'an, ShaanxiAges 18 years+ - NCT07095439RecruitingPhase 2
Sandwich treatment for stage 2 and 3 rectal cancer
This trial tests a new way of giving radiation and chemotherapy before surgery for rectal cancer that hasn't spread. It aims to see if this 'sandwich' approach is safe and works better than standard treatment.
CairoAges 18–70 - NCT07108127RecruitingPhase 2
Targeted drugs plus chemo for HER2-positive rectal cancer
This trial tests whether a combination of two targeted drugs (trastuzumab and pertuzumab biosimilars) plus chemotherapy can shrink advanced HER2-positive rectal cancer before surgery. It aims to improve response and potentially reduce the need for more aggressive treatments.
BeijingAges 18 years+ - NCT07112937Recruiting
Effect of rectal cancer treatment on tumor cells in blood
This study looks at how different treatments for rectal cancer affect tumor cells that travel in your blood. It is an observational study, meaning you will not receive any new treatment, but your blood will be tested to help doctors learn more.
OstravaAges 18 years+ - NCT07113275RecruitingPhase 3
Short versus long radiation schedule for advanced rectal cancer
This study compares two different schedules of radiation (a short course versus a longer course) followed by standard chemotherapy and immunotherapy for advanced rectal cancer. It aims to see which approach works best to shrink the tumor before surgery.
Wuhan, HubeiAges 18–75 - NCT07177742Recruiting
Study of protein in blood to predict liver spread of colon cancer
This study looks at whether a substance in your blood (called PRDX1, found in tiny particles called exosomes) can help predict if colon cancer will spread to the liver after surgery. It may help doctors understand who needs more monitoring or treatment.
Shanghai, Shanghai MunicipalityAges 1.6 years–6.7 years - NCT07188025RecruitingPhase 3
Cancer DNA test to guide chemo after rectal cancer surgery
This trial tests whether checking for tumor DNA in your blood after surgery can help decide if you need additional chemotherapy. If the test finds cancer DNA, you may get chemo to lower the risk of the cancer coming back.
's-HertogenboschAges 18 years+ - NCT07194616Recruiting
Rectal cancer blood test study before surgery
This trial is studying a blood test (CTC) for people with rectal cancer that hasn't spread to other parts of the body. It aims to see how the test relates to treatment outcomes after surgery.
OlomoucAges 18 years+ - NCT07209787RecruitingPhase 4
Reinforced vs. standard connection for rectal cancer surgery
This trial tests whether a special reinforcement patch (made from pig tissue) can reduce the risk of leaks when the rectum is reconnected after rectal cancer surgery. It compares the reinforced connection to the standard method.
Beijing, Beijing MunicipalityAges Up to 85 years - NCT07239466RecruitingPhase 2
Ketone supplement with radiation and chemo for rectal cancer
This study tests a combination of a special diet supplement (beta-hydroxybutyrate), short radiation therapy, immunotherapy, and chemotherapy before surgery for locally advanced rectal cancer. The goal is to see if this approach helps shrink the tumor and improve treatment outcomes.
Wuhan, HubeiAges 18–75 - NCT07260526Recruiting
Chemo and radiation for low rectal cancer, aiming to avoid surgery
This trial tests whether people with early- to intermediate-stage low rectal cancer can avoid surgery if their tumor responds well to a full course of chemotherapy and radiation. It starts with brief chemotherapy, then adjusts treatment based on how much the tumor shrinks.
Chengdu, SichuanAges 18–80 - NCT07279077RecruitingPhase 2
Low-dose radiation with chemo and immunotherapy for high-risk colon cancer
This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT07337876RecruitingPhase 2
Avoiding surgery for rectal cancer with precise radiation
This trial tests a new way to give high-dose radiation to rectal cancer tumors while avoiding the bladder and bowels. The goal is to cure the cancer without removing the rectum, so you may keep normal bowel function.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07079631RecruitingPhase 1/Phase 2
Testing BNT314 with pumitamig and chemo for advanced colorectal cancer
This trial tests a new combination of drugs (BNT314 and pumitamig) plus chemotherapy for people with advanced colorectal cancer that has not responded to prior treatments. The goal is to see if this combination is safe and helps shrink or control the cancer.
New Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 898 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.