Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 867 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06557733RecruitingPhase 2
Investigating TPST-1495 for Familial Adenomatous Polyposis
This trial tests a new drug, TPST-1495, to reduce the number of benign polyps in the small intestine for people with a condition called familial adenomatous polyposis (FAP). If you join, you will likely not know if you receive the drug or a placebo, to see if the drug is helpful.
Phoenix, ArizonaAges 18 years+ - NCT05963191Recruiting
Test camera bowel scan for early Lynch syndrome lesions
This study tests a special CAD-EYE system to help detect abnormal (potentially cancer-related) growths during colonoscopy in people with Lynch syndrome. It may improve how reliably clinicians find lesions early, when treatment can be easier.
ParisAges 18–90 - NCT06542757Recruiting
Focused radiation to main prostate tumor using MRI guidance
This trial tests a stronger, more focused radiation dose to the main tumor inside the prostate using MRI guidance. It aims to improve control of intermediate-risk prostate cancer while possibly reducing side effects.
New York, New YorkAges 18 years+ - NCT06317727Recruiting
Pulsed field ablation for removing colon polyps
This study tests a new way to remove colon polyps using short bursts of energy (pulsed field ablation) instead of standard methods. It may help people with polyps in the lower part of the colon that are not too large or complex.
LondonAges 18 years+ - NCT06236633Recruiting
Blocking an artery before rectal cancer surgery
This trial tests a technique called ischemic preconditioning, where doctors temporarily block a main artery in your gut before rectal cancer surgery to see if it helps reduce complications. If you are scheduled for this type of surgery and meet the health criteria, the study may offer more information about safer recovery.
MontpellierAges 18–90 - NCT04792684Recruiting
Collecting colon samples from adults with colon findings
This study collects body samples to help evaluate tests for people with suspected or newly diagnosed colorectal conditions, often around the time of colonoscopy or surgery. Depending on the arm, you may be asked to have a colonoscopy soon or to provide samples before planned surgery.
Chula Vista, CaliforniaAges 45–84 - NCT06063928Recruiting
Cancer support study for Hispanic patients
This study explores how community support affects Hispanic people with colon or rectal cancer. You provide a tumor sample and answer questions to help researchers learn how to better support patients like you.
Los Angeles, CaliforniaAges 18 years+ - NCT06015607Recruiting
Testing a new tool for colon polyp removal
This trial tests a new device to help doctors remove larger, non-cancerous polyps from the colon during a colonoscopy. It may make the procedure easier and more effective for eligible patients.
Cleveland, OhioAges 21 years+ - NCT05977621Recruiting
Ultrasound imaging to guide radiation needle placement
This trial tests a guidance technique that uses ultrasound images matched to MRI (a real-time “map”) to help track the needle position during treatment for cervical or uterine cancer. It may help make radiation treatments more precise for people who are getting curative-intent radiation with brachytherapy.
Durham, North CarolinaAges 18–90 - NCT05884723Recruiting
Ketogenic diet before liver surgery for fatty liver
This trial tests whether a ketogenic (very low-carb) diet before liver surgery can reduce fat in the liver. It is aimed at people with colorectal liver metastases who already have fatty liver seen on scans or biopsy.
London, OntarioAges 18 years+ - NCT05652361Recruiting
AI guidance system for robotic rectal cancer surgery
This trial tests a machine-learning (AI) system that may help guide surgeons during robotic rectal cancer operations. It’s meant to support safer, more accurate surgery while comparing outcomes to standard surgical guidance.
Dresden, SaxonyAges 18 years+ - NCT05404230Recruiting
Preventing nerve damage from oxaliplatin in the hands and feet
This study looks at ways to prevent numbness or nerve pain in the hands and feet that can happen from oxaliplatin treatment. It includes people with colon or rectal cancer who will be getting standard chemotherapy with capecitabine plus oxaliplatin.
AalborgAges 18 years+ - NCT05254327RecruitingPhase 2
Radiation plus or minus BMX-001 for advanced rectal cancer
This Phase 2 study tests two different ways of giving radiation before surgery for locally advanced rectal cancer, with or without an added study drug called BMX-001. It aims to see whether the shorter/longer radiation plans and BMX-001 improve cancer control and are safe.
Lexington, KentuckyAges 18 years+ - NCT05195710RecruitingPhase 1
Pre-surgery Y-90 treatment to grow future liver volume
This trial tests a radiation treatment called Y-90 given before liver surgery for colorectal cancer that has spread to the liver. The goal is to help the liver grow enough for safer, curative surgery, either right away or as part of a two-step operation.
Houston, TexasAges 18 years+ - NCT04925154Recruiting
Study of decision-making for rectal cancer treatment
This study asks people newly diagnosed with rectal cancer about how they choose between treatment benefits and quality of life. It uses questionnaires to understand what tradeoffs matter to patients so care discussions can be improved.
Montreal, QuebecAges 18 years+ - NCT04815694Recruiting
MRI-guided radiotherapy for rectal cancer
This trial tests whether using MRI scans to guide radiotherapy can improve treatment for people with a certain type of rectal cancer. It focuses on patients whose tumors have not spread to other parts of the body and who have specific tumor features seen on MRI.
Roma, RomaAges 18 years+ - NCT04666727Recruiting
Diet and gut microbiome study during screening colonoscopy
This study looks at how a person’s diet (vegetarian vs. omnivorous) affects the germs in the gut and related stool and tissue samples. You may be able to join if you’re getting a screening colonoscopy and meet lifestyle and medication requirements.
Houston, TexasAges 45 years+ - NCT04165772RecruitingPhase 2
Dostarlimab for locally advanced mismatch-repair deficient solid tumors
This Phase 2 trial studies dostarlimab (an immune therapy that targets PD-1) given before surgery or other initial treatment. It aims to shrink certain locally advanced cancers that have mismatch repair deficiency, potentially making treatment easier and improving outcomes.
Hartford, ConnecticutAges 18 years+ - NCT04575935RecruitingPhase 3
Minimally invasive surgery after chemotherapy for advanced ovarian cancer
This trial studies whether doing surgery using smaller incisions after chemotherapy works as well as a more traditional approach for certain people with stage IIIC–IV ovarian, fallopian tube, or primary peritoneal cancer. It may help reduce surgical trauma while aiming for effective tumor removal.
Miami, FloridaAges 18 years+ - NCT04945642Recruiting
Radiation combination therapy for intermediate to high-risk prostate cancer
This trial studies a combination of two radiation types—high-dose-rate brachytherapy and stereotactic body radiotherapy—to treat certain intermediate- to high-risk prostate cancers. It may help by aiming radiation closely at the prostate while also targeting the cancer from outside the body.
Los Angeles, CaliforniaAges 18 years+ - NCT04725903Recruiting
Proton beam radiation for high-risk prostate cancer
This trial tests proton radiation therapy for people with high-risk prostate cancer. It may help by delivering radiation in a more targeted way, with the goal of controlling the cancer while reducing exposure to nearby healthy tissue.
Atlanta, GeorgiaAges 18 years+ - NCT06330805RecruitingPhase 2
Comparing heart effects of two hormone therapies for prostate cancer
This trial compares two hormone therapies, relugolix and leuprolide, to see which one is better for your heart health in men with prostate cancer. It's for men with a specific type of prostate cancer that is not yet advanced.
Columbus, OhioAges 18 years+ - NCT02594202Recruiting
Collecting prostate cancer care details and prostate tissue samples
This trial enrolls adults who are being evaluated or treated for possible or confirmed prostate cancer and allows researchers to collect prostate tissue. It may help improve understanding of prostate cancer over the course of diagnosis and standard care.
Bethesda, MarylandAges 18 years+ - NCT07856017Recruiting
Smarter prostate biopsy using imaging and metabolic data
This study tests a new biopsy system that uses MRI images and metabolic information to guide doctors to the most suspicious areas of the prostate during the biopsy. This could make the biopsy more accurate and help diagnose prostate cancer better.
ShanghaiAges 55 years+
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 867 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.