Clinical trials
Coronary artery disease clinical trials
Narrowing of the arteries that supply blood to the heart. We’re tracking 712 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06708000Enrolling by invitationPhase 3
Personalized testing for new chest pain
This trial compares a personalized evaluation approach to standard care for people with new chest pain who might have heart disease. It aims to see if tailoring tests can improve diagnosis and outcomes.
HerningAges 30–75 - NCT06710210Recruiting
Combining two heart treatments for long blocked arteries
This study tests a new way to treat long, narrow blockages in the heart's arteries. It combines a temporary scaffold with a drug-coated balloon, which may help the artery heal without a permanent metal stent. This could be an option for people who need their artery opened but may benefit from a less permanent approach.
Geneva, Canton of GenevaAges 18 years+ - NCT05437965Recruiting
Registry study for repeat coronary blockages after stents
This study follows adults who have fast, unexplained re-narrowing of a coronary stent, to better understand what causes it and how to monitor it. You may help by allowing the study team to collect medical information over time.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06207318Recruiting
Acceptance and commitment therapy before and after bypass surgery
This study tests if Acceptance and Commitment Therapy (ACT), a type of counseling that helps you handle difficult emotions and thoughts, can improve recovery after coronary artery bypass graft (CABG) surgery. It is for people who are scheduled for bypass surgery and can attend video or phone sessions.
Iowa City, IowaAges 18–80 - NCT06681740Recruiting
Breathing muscle training for heart disease patients
This study tests whether a special breathing exercise program can help people who have had a heart attack and a procedure to open blocked heart arteries. The exercises strengthen the muscles you use to breathe, which may improve your recovery and quality of life.
MálagaAges 18–80 - NCT06686121RecruitingPhase 3
Walking recovery after leg artery treatment
This study tests whether a home-based exercise program or a special beetroot drink can help people walk better after having a procedure to improve blood flow in their legs. It aims to find ways to boost mobility and quality of life.
Tucson, ArizonaAges 18 years+ - NCT06657833Recruiting
Drug Balloon vs Stent for Calcified Nodules After Shockwave
This trial tests whether a drug-coated balloon (a tiny balloon that releases medicine) works as well as a drug-coated stent (a mesh tube) for treating hard calcium deposits in heart arteries. Patients first receive a special shockwave treatment to break up the calcium.
LeidenAges 18 years+ - NCT06631157Recruiting
Essential Pro study for routine hospital patients
This trial is studying the Essential Pro device or treatment in patients who are already using it as part of their normal hospital care. The goal is to see how well it works in everyday practice.
Lai Chi KokAges 18 years+ - NCT06625801Recruiting
IVUS-guided heart procedure registry for minority patients
This study is collecting information from heart procedures that use IVUS (a special ultrasound inside the blood vessels) to treat complex blockages. It aims to learn how well these procedures work in patients who identify as a racial or ethnic minority.
Phoenix, ArizonaAges 18 years+ - NCT06603363Recruiting
Statin effects on heart artery plaques seen on CT scans
This trial studies how short-term statin therapy changes plaque buildup in heart arteries. It uses CT scans to see if statins can make plaques more stable and reduce heart risks.
Budapest, BudapestAges 45–75 - NCT06600178RecruitingPhase 1
Heart medication for women with chest pain and small vessel disease
This trial tests a diabetes medication called SGLT2 inhibitors to see if it can improve blood flow to the heart and reduce chest pain in women who have small vessel heart disease (microvascular dysfunction) but not blocked large arteries. Participants will take the medication and be monitored for symptom relief and heart function improvements.
Charlottesville, VirginiaAges 18 years+ - NCT06579807Recruiting
Cardiac rehab for coronary artery disease
This study tests if a cardiac rehabilitation program helps people with coronary artery disease. You can join if you are between 40 and 70, have heart disease (or are a healthy volunteer), and do not have other health issues like heart failure or smoking.
Rio de Janeiro, Rio de JaneiroAges 40–70 - NCT06572267RecruitingPhase 2
Meplazumab for coronary artery disease
This trial tests if meplazumab can help people with chronic coronary syndrome who have stable angina. It focuses on patients with certain fatty deposits around their heart arteries that show up on a special CT scan.
Xi'an, ShannxiAges 18 years+ - NCT06578234RecruitingPhase 4
Comparing Adenosine Doses for Heart MRI
This study will compare different doses of adenosine during a heart MRI to find the best dose for measuring blood flow to the heart muscle. It is for people with known or possible coronary artery disease or heart failure, as well as healthy volunteers.
LundAges 40 years+ - NCT05367297Recruiting
Registry study of heart plaque in South Asian adults
This study tracks coronary plaque (fatty deposits in heart arteries) in South Asian adults and compares them with people of other backgrounds. You may be asked to have a special heart CT scan and basic measurements to help researchers understand differences in heart disease risk.
Dallas, TexasAges 18 years+ - NCT06074549Recruiting
DynamX bioadaptor heart artery trial
This trial studies a new type of device called the DynamX Bioadaptor, which is placed inside a blocked heart artery to help it heal and flex naturally. It is designed for people who need a stent (a tiny tube to open a blocked artery) and may offer a more adaptive option than traditional stents.
PöltenAges 18 years+ - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT06551662Recruiting
Balloon vs. stent for split artery blockages
This trial compares two ways to open a blocked artery that splits into two branches (a bifurcation): using a balloon coated with medicine (drug-coated balloon, or DCB) versus a drug-eluting stent (DES). The goal is to see which approach works better for patients with this type of blockage.
MilanAges 18 years+ - NCT06542432Enrolling by invitation
Genetic risk test for heart disease prevention
This trial uses a polygenic risk score to see if knowing your genetic risk for coronary artery disease can help prevent a first heart attack. If you have an intermediate 10-year risk and no prior heart events, you may be eligible.
Rochester, MinnesotaAges 40–70 - NCT06535568Recruiting
Comparing one vs two blood thinners after heart artery balloon treatment
This trial tests whether taking just one blood thinner (clopidogrel) is as safe and effective as taking two (clopidogrel plus aspirin) for older adults or people at high bleeding risk who have had a drug-coated balloon procedure to open blocked heart arteries.
Milan, MIAges Any age - NCT06507449Enrolling by invitation
Treating Heavily Calcified Heart Blockages to Improve Microcirculation
This study is testing a technique to treat heavily calcified (hard) blockages in heart arteries. The goal is to see if a special way of preparing the blockage before placing a stent helps improve blood flow to the tiny blood vessels in the heart muscle.
KatowiceAges 18 years+ - NCT06489119Recruiting
Studying plaque types in coronary artery disease with advanced imaging
This trial uses advanced imaging (OCT) and single-cell analysis to study different types of plaque in people with coronary artery disease. It aims to understand how these plaque types differ at a cellular level, which could lead to better treatments.
Harbin, HeilongjiangAges 18–85 - NCT06216847Recruiting
Heart artery disease study: comparing imaging and function tests
This study looks at people with coronary artery disease (narrowed or blocked heart arteries) to see how different imaging and function tests can help predict outcomes. If you've had a heart procedure or test showing blockages, you might be eligible.
Shenyang, LiaoningAges 18 years+ - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Gilbert, ArizonaAges 18–80
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Common questions
- Are there clinical trials for coronary artery disease?
- Yes. Clin2 currently lists 712 recruiting coronary artery disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.