Coronary Heart Disease clinical trials

Chronic total occlusion procedure registry

This study collects data from patients who are having a procedure to open a completely blocked coronary artery. It may help improve future treatments for this condition.

Berberine after stent placement to reduce blood-platelet effects

This trial studies whether berberine changes how strongly your platelets “stick together” after a coronary stent. It may help reduce risk related to clotting while you continue standard heart medicines (aspirin and clopidogrel).

Switching from cigarettes to heat-not-burn to protect heart arteries

This study looks at whether switching from regular cigarettes to a tobacco heating product slows buildup of plaque in the heart arteries. You’d be guided through smoking change and monitored using heart scans, to see if artery plaque stays the same or improves.

Heart failure risk after bypass surgery

This study looks at how to predict major heart problems in people with heart failure who are scheduled for bypass surgery (CABG). It aims to improve risk assessment before the procedure.

Colchicine and vitamin B1 for ischemic heart failure

This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.

Testing heart muscle health with PET/MR scan

This study uses a special imaging test (PET/MR) to check if damaged heart muscle is still alive and can recover. It is for people with severe blocked arteries and weak heart pumping function who are planning bypass surgery or stem cell treatment.

Stent treatment study for blocked heart arteries

This study tests a coronary stent approach for people with significantly blocked heart arteries. It may help by improving blood flow, and it compares treatment in a structured way while monitoring safety and outcomes.

Blood sample study for better health screening

This study collects blood samples and health information over time to improve early detection of diseases. It may help researchers find ways to prevent serious conditions.

Compare two stomach-protecting medicines to prevent bleeding

This trial compares a potassium-competitive acid blocker to a proton pump inhibitor to help prevent stomach or intestinal bleeding in people at high risk who take blood-thinning medicines. It may help reduce dangerous GI bleeding while you stay on heart/stroke medicines.

Comparing blood pressure drugs after heart stent placement

This trial compares two different combinations of blood pressure medicines to see which works better for people who have had a heart stent placed. It may help find the best treatment plan for controlling blood pressure after the procedure.

AI-Guided Heart Artery Pressure Test vs Standard Test

This study compares a new artificial intelligence (AI) method to measure blood flow in your heart arteries (called Medipixel FFR) with the standard invasive method. If you are scheduled for a heart angiogram or stenting and have a moderate blockage (40-90% narrowing) that doctors are unsure about, this AI tool may help decide the best treatment for you.

CTO treatment vs medicines after heart scan

This trial studies whether opening a blocked coronary artery (a CTO) helps people more than staying on the best available heart medicines after an initial 3-month treatment period. It uses heart imaging to confirm there is reduced blood flow in the area supplied by the blockage.

Comparing bypass surgery vs stenting for minority heart patients

This trial compares two common heart procedures—bypass surgery and stenting—for people with multiple blocked arteries. It focuses on minority groups to find out which treatment works best for them. You will be asked to fill out quality-of-life questionnaires for up to 10 years.

Shock wave vs drill for hard calcium in heart arteries

This study tests a new way to break up hard calcium deposits in heart arteries using shock waves (lithotripsy), with or without a special drill (rotational atherectomy), before placing a stent. It may help people with severely calcified blockages that are hard to treat with standard methods.

Balloon treatment for blocked heart arteries

This trial tests how the way a drug-coated balloon is used during a heart procedure affects outcomes for people with stable heart disease or unstable angina. It may help doctors find the best technique to keep arteries open.

Heart mapping test for stable coronary artery disease treatment

This trial tests whether a non-invasive heart mapping technique can guide treatment for stable coronary artery disease, potentially avoiding more expensive or invasive tests. You may join if you have stable angina and a blockage of 50-90% in a major heart artery.

Study on why doctors don't use heart imaging during stent placement

This study looks at reasons doctors may or may not use a special camera inside the heart arteries (called OCT or IVUS) during a procedure to open blocked arteries. It may help understand how to improve care for people with complex blockages.

Study of heart pain from small artery heart disease

This trial studies people who have chest pain (angina) due to problems with the heart’s small arteries, not a big blockage. It aims to test whether treatment approaches can help these patients by better understanding the cause of their heart-related symptoms.

Best practices for heart failure with leaky mitral valve

This trial compares two treatment approaches for people with heart failure and a leaky mitral valve (mitral regurgitation). It aims to find which strategy leads to better outcomes. You may be eligible if your heart function is reduced and you have symptoms despite standard treatments.

Tests for stable chest pain using heart scans and pressure measurements

This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.

Testing an online decision aid for heart and kidney disease

This study is testing an online tool called 'My Heart and CKD' that helps people with both chronic kidney disease and heart disease make decisions about their care. The goal is to see if it is easy to use and helpful for patients and their doctors.

Effect of High-Intensity Interval Training Versus Home-Based Rehabilitation Program On Patients Underwent Coronary Artery Bypass Graft Surgery

Heart treatment study for women with blocked arteries

This trial is comparing two common heart procedures—bypass surgery (CABG) and stents (PCI)—to see which works better for women with blockages in multiple heart arteries. It aims to find the best treatment for women, who are often underrepresented in heart research.

Balloon treatment test for narrowed stents in heart arteries

This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.