Clinical trials
Critical Illness clinical trials
Below are recruiting critical illness clinical trials, each written for real people, not researchers. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06341972Recruiting
Recovering after breathing support: a self-help program
This study tests a self-management program to help people who felt anxious after being on a breathing machine in the ICU. It aims to improve emotional recovery and quality of life.
Baltimore, MarylandAges 18 years+ - NCT06323226Recruiting
Sepsis long-term outcomes in critically ill children
This study looks at how sepsis (a severe infection that can affect the whole body) affects children after they leave the intensive care unit. It compares children who had sepsis to those with other critical illnesses to understand long-term health.
Chengdu, SichuanAges birth–16 years - NCT06285162Recruiting
Nerve health monitor during ICU dialysis
This trial uses a special monitor (called ANI) to check how well your nervous system is working while you are on continuous kidney dialysis in the ICU. It may help doctors better understand your body's response to fluid removal.
BronAges 18 years+ - NCT06269900RecruitingPhase 3
Dexamethasone for Severe Hospital-Acquired Pneumonia with Inflammation
This trial tests whether adding the anti-inflammatory drug dexamethasone to standard antibiotics improves recovery from severe hospital-acquired pneumonia in critically ill patients on a ventilator.
AmiensAges 18–85 - NCT06229990RecruitingPhase 4
Using furosemide stress test to stop kidney replacement therapy
This study tests whether a furosemide (a water pill) stress test can help doctors decide when to safely stop continuous kidney replacement therapy in ICU patients with severe acute kidney injury. It may allow you to come off the machine sooner if your kidneys respond well.
Chiang MaiAges 20 years+ - NCT06208332RecruitingPhase 2
Communication support for kids with severe neurological needs
This study tests a new communication program to help families and doctors talk about what matters most to your child with a severe neurological condition. It is for hospitalized children ages 6 months to 25 years old, who have had their condition for more than 6 months.
Seattle, WashingtonAges 6 months+ - NCT06189924Recruiting
Breath analysis in ventilated ICU patients
This study collects and analyzes the moisture you breathe out while on a ventilator in the ICU. It aims to learn more about your condition by examining your breath.
OlomoucAges 18 years+ - NCT06193980Recruiting
ICU recovery exercise test study
This trial looks at how well your heart and lungs work together after a long stay in the ICU on a breathing machine. It uses a simple exercise test to check your recovery after leaving the hospital.
Winnipeg, ManitobaAges 18 years+ - NCT06184945Recruiting
Behavioral and staffing strategies in the ICU
This study tests different ways of organizing care and supporting patients in the intensive care unit (ICU) to see if they can improve recovery and well-being. It focuses on adults who need a breathing tube and are in the ICU for at least a day.
Iowa City, IowaAges 19 years+ - NCT06179771Recruiting
Filter during dialysis or ECMO for severe illness
This study tests a special filter (HA380 column) used during dialysis or ECMO to remove harmful substances from the blood. It is for critically ill patients with severe infection, injury, or breathing problems who also need kidney or lung support.
Leicester, LeicestershireAges 18–65 - NCT06150326Recruiting
Medical honey for wound treatment in intensive care
This trial tests whether medical honey can help heal wounds like bedsores, cuts, or surgical openings in intensive care patients. If you have a fresh wound that meets the size requirements, you may be able to join.
AngersAges 18 years+ - NCT06117345Enrolling by invitation
PICU Journal for Parents and Caregivers
This study tests a journal to help parents and caregivers stay involved while their child is in the pediatric intensive care unit (PICU). It aims to see if the journal improves communication and engagement.
Nashville, TennesseeAges 18 years+ - NCT05906472Recruiting
Feeding through a tube after tracheostomy in the ICU
This study tests a specific way of continuing tube feeding for people who need a tracheostomy after being on a breathing tube in the ICU. The goal is to see if this feeding approach is safe and beneficial for recovery.
Danbury, ConnecticutAges 18 years+ - NCT02804438Recruiting
Pupil measurement checks in neurocritical care patients
This study collects normal (baseline) results from a handheld eye pupil camera (a pupillometer) used during routine neuro–intensive care checks. It may help clinicians better interpret these eye measurements in future patients.
Dallas, TexasAges Any age - NCT06014801RecruitingPhase 2/Phase 3
Comparing low vs. medium continuous dialysis for kidney injury in the ICU
This study compares two intensities (low vs. medium) of continuous dialysis for people with sudden kidney failure in the ICU. It aims to find which level of treatment works best for critically ill patients.
Sendai, MiyagiAges 18 years+ - NCT02539407Recruiting
Study drug levels in critically ill children
This trial measures how anti-infective medicines move through a child’s body while they are in the hospital or during follow-up. The goal is to better understand dosing and drug exposure in critically ill children.
ParisAges 1 day–18 years - NCT04166877RecruitingPhase 4
Magnesium drip to reduce pain in ICU trauma patients
This trial tests whether a magnesium infusion can better control pain in adults who have serious injuries and need intensive care. It compares magnesium as part of pain treatment to standard pain care to see if pain improves and stays controlled.
Sacramento, CaliforniaAges 18 years+ - NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT05673408Recruiting
Check how well a blood pressure cuff reads in critically ill patients
This study tests whether a noninvasive blood pressure (NIBP) cuff gives accurate readings in people being cared for in intensive care or the operating room. It will compare the cuff’s numbers to blood pressure measured through an arterial line in different patient groups.
Jacksonville, FloridaAges Any age - NCT05616130Recruiting
Study of abnormal blood immune activation after trauma or elective hip surgery
This study looks at how the body’s blood-related immune system “switches on” in unusual ways after a major injury or elective hip repair. The researchers hope this helps them understand who is at risk for complications and why, by measuring changes in your blood around the time of surgery or hospital treatment.
Gainesville, FloridaAges 18–100 - NCT05551325Recruiting
Resetting sleep timing for ICU patients to support recovery
This study tests a “sleep chronobundle,” a set of sleep and light-timing steps, to improve daily sleep-wake timing in people in the ICU on breathing or blood-pressure support. It also checks whether the body’s sleep rhythms are more aligned during critical illness and over time.
New Haven, ConnecticutAges 18 years+ - NCT05513456Recruiting
ICU doctors and trainees answer a fast online case survey
This study asks intensive care doctors (including trainees) to respond to short ICU case scenarios in a randomized survey. It aims to see whether people’s answers differ by gender and ethnicity, which could help improve fairness and education in ICU decision-making.
StockholmAges Any age - NCT05541029Recruiting
Music listening for children on breathing machines
This study tests whether listening to music can help children who are in the Pediatric Intensive Care Unit (PICU) and need a breathing machine. It looks at the “how it works” side—whether music changes things in the body or brain during intensive care.
Pittsburgh, PennsylvaniaAges 2 months–17 years - NCT05453695RecruitingPhase 1
IV DNase for ICU sepsis with organ stress
This Phase 1 study tests whether an IV medicine called DNase I can safely help people with sepsis who are having worsening organ function. It’s designed to see if the treatment is tolerated and could improve outcomes for ICU patients with early sepsis.
Hamilton, OntarioAges 18–100
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Common questions
- Are there clinical trials for critical illness?
- Yes. Clin2 currently lists 333 recruiting critical illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critical illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critical illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.