Clinical trials
Critically Ill clinical trials
Below are recruiting critically ill clinical trials, each written for real people, not researchers. We’re tracking 352 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06258551Recruiting
Tracking hard-to-treat bacteria in ICU and transplant patients
This study will track how certain hard-to-treat bacteria spread and cause infections in people who are in the intensive care unit (ICU) or have had a stem cell transplant. The goal is to better understand and prevent these infections in vulnerable patients.
Houston, TexasAges 18 years+ - NCT06259565RecruitingPhase 3
Breathing mask sedation trial for agitated adults
This trial tests whether adding a sedative called dexmedetomidine to non-invasive ventilation (a breathing mask) helps adults who are agitated or uncomfortable while on the mask. It aims to improve comfort and avoid the need for a breathing tube.
Surrey, British ColumbiaAges 18 years+ - NCT07522580Recruiting
Heart Fluid Response Monitoring in Critically Ill Children
This study tests a simple, non-invasive device that measures how well a child's heart responds when doctors give extra fluids during intensive care. It helps doctors decide if more fluids will actually help the child feel better.
Le Plessis-Robinson, FranceAges birth–8 years - NCT07642076RecruitingPhase 4
L-carnitine supplement for critically ill liver disease patients
This study tests whether adding L-carnitine (a naturally occurring compound) to standard care helps people with serious liver disease who are in the intensive care unit. L-carnitine may help the body use energy better and reduce complications from liver failure.
MenoufiaAges 18 years+ - NCT06285162Recruiting
Nerve health monitor during ICU dialysis
This trial uses a special monitor (called ANI) to check how well your nervous system is working while you are on continuous kidney dialysis in the ICU. It may help doctors better understand your body's response to fluid removal.
BronAges 18 years+ - NCT07077174Recruiting
Permissive lung-protective ventilation for critically ill patients on a breathing machine
This trial tests whether a more lenient approach to lung-protective ventilation can improve outcomes for patients who need a breathing machine (ventilator) in the intensive care unit. It aims to find a balance that is safer for the lungs while still being effective.
AlmeloAges 18 years+ - NCT06934876Recruiting
Comparing two CO2 detectors during breathing tube placement in critically ill adults
This study compares two ways of checking that a breathing tube is placed correctly in seriously ill adults: one uses a device that shows a waveform on a screen, and the other uses a color-changing test. It may help doctors choose the best method for patients in the emergency room or ICU.
Chicago, IllinoisAges 18 years+ - NCT07118384Recruiting
Comparing two antibiotics for drug-resistant infections
This trial tests two different antibiotic combinations (ampicillin/sulbactam and cefoperazone/sulbactam) to see which works better against a type of bacteria (Acinetobacter baumannii) that is resistant to many other drugs. It is for critically ill patients with signs of sepsis.
CairoAges 21 years+ - NCT07722260Recruiting
Cough assistance for breathing tube weaning
This study tests whether special cough-aid techniques help adults on breathing tubes get off the ventilator faster. It may be an option for patients who need extra help coughing while they recover.
DamanhūrAges 18 years+ - NCT07519512Recruiting
Early Switch to Assisted Breathing in ICU Patients
This study tests whether moving ICU patients from fully machine-controlled breathing to partially assisted breathing earlier helps them get off ventilators successfully. The goal is to see if this approach reduces the time patients need mechanical ventilation.
Nanjing, JiangsuAges 18 years+ - NCT07409727RecruitingPhase 4
Acetylcysteine inhalation to prevent pneumonia in ventilated patients
This trial tests if breathing in a medication called acetylcysteine can help prevent lung infections in patients who are on a breathing machine. If you or a loved one is on a ventilator, this treatment might reduce the chance of getting ventilator-associated pneumonia.
CairoAges 18–64 - NCT07339397Recruiting
Joint stiffness in ICU patients on breathing machines
This trial studies how common joint stiffness becomes in ICU patients who are on a breathing machine and cannot move for at least 7 days. It may help doctors better prevent and treat this problem.
Elâzığ, ElaziğAges 18 years+ - NCT07329530Recruiting
Muscle and metabolism study in ICU survivors
This study looks at muscle and metabolism changes in people who have been in the ICU for at least 7 days after major abdominal surgery. It aims to understand how recovery affects the body.
LiègeAges 18 years+ - NCT06961227Recruiting
Comparing two breathing machine settings in the ICU
This trial compares two different ways a breathing machine can help you breathe. It uses a special imaging technique to see which method works better for patients in the intensive care unit.
SanliurfaAges 18 years+ - NCT06669494Enrolling by invitation
Study on ICU muscle weakness detection and monitoring
This study aims to find better ways to detect and track muscle weakness that can happen during an ICU stay. If you or your loved one is in the ICU, this research could help improve early diagnosis and care.
Seoul, SeoulAges 18 years+ - NCT07254299Recruiting
Hypnosis for ICU recovery and wellbeing
This study tests whether hypnosis sessions during an ICU stay can improve mental and physical recovery after a serious illness. It aims to reduce long-term problems like anxiety, depression, and memory issues.
GenevaAges 18 years+ - NCT06920173RecruitingPhase 2
Low-dose vasopressors for shock in the ICU
This study tests whether giving low-dose blood pressure medicines through a standard IV (instead of a larger central line) is safe and effective for patients with shock in the intensive care unit.
Kingston, OntarioAges 18 years+ - NCT07468006Recruiting
Comparing carbon dioxide measurements in critically ill children
This trial tests if a sticker on the skin can accurately measure carbon dioxide levels in the blood, reducing the need for needle sticks in children in the intensive care unit.
BrnoAges 1–18 - NCT06840756RecruitingPhase 4
Does donor-patient sex matching improve blood transfusion outcomes?
This trial tests whether giving ICU patients blood from a donor of the same sex (male-to-male or female-to-female) leads to better recovery compared to mismatched transfusions. The goal is to see if matching donor and patient sex makes a difference in how well patients do.
Hamilton, OntarioAges 18 years+ - NCT07188350Recruiting
Electrical muscle stimulation for patients on a breathing machine
This trial tests whether low-level electrical pulses to the leg muscles can help prevent weakness in patients who need a breathing tube (ventilator) for more than 48 hours. It aims to see if this treatment helps patients recover faster.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07205952Recruiting
Detecting breathing difficulty in ventilated patients
This study looks at whether a computer system can automatically detect when a patient on a breathing machine (ventilator) is having trouble breathing. It may help doctors respond faster to the patient's needs.
Buenos Aires, Buenos AiresAges Any age - NCT06584604Recruiting
Calibrating esophageal balloon for breathing machine patients
This trial is testing how to calibrate an esophageal balloon (a thin tube that measures pressure in your chest) for people on a breathing machine. If you are already sedated and have this tube in place, participating may help doctors get more accurate readings to improve your breathing support.
Leiden, South HollandAges 18 years+ - NCT06575530RecruitingPhase 4
Remimazolam for sedation after non-cardiac surgery
This trial tests a sedative called remimazolam besylate in patients who need a breathing tube and light sedation after non-cardiac surgery. The goal is to see if it works well and is safe.
Beijing, Beijing MunicipalityAges 18–64 - NCT06547892RecruitingPhase 2
Vasopressin to prevent kidney injury in the ICU
This trial tests if a drug called vasopressin can help prevent acute kidney injury in patients at high risk. It's for adults in the ICU who have a predicted risk score of 5 or higher based on their lab and health data.
São Paulo, São PauloAges 18 years+
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Common questions
- Are there clinical trials for critically ill?
- Yes. Clin2 currently lists 352 recruiting critically ill studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.