Clinical trials
Critically Ill clinical trials
Below are recruiting critically ill clinical trials, each written for real people, not researchers. We’re tracking 336 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06460363Recruiting
Electrical brain stimulation for delirium in ICU patients
This trial tests whether a gentle electrical current applied to the scalp can help treat delirium (sudden confusion) in intensive care patients. It aims to improve recovery in people who have had confusion for more than 24 hours.
KuopioAges 18 years+ - NCT02299921Recruiting
Alcohol and drug effects on immunity in ICU breathing patients
This study looks at how alcohol and other drugs can affect the body’s immune system in people who are very sick in the ICU due to breathing problems. It may help doctors better understand immune changes during critical illness and respiratory failure.
Aurora, ColoradoAges 18–90 - NCT06570187RecruitingPhase 4
Dexmedetomidine for kidney protection in sepsis
This trial tests if dexmedetomidine, a sedative, can help protect the kidneys of critically ill patients with sepsis who develop acute kidney injury (a sudden drop in kidney function). It is for adults in the ICU who need a breathing tube or mask within 48 hours of kidney injury.
CairoAges 18–90 - NCT07722897Recruiting
Monitoring brain activity during emergency intubation
This study tests whether monitoring brain activity (using a sensor on the forehead) during emergency intubation helps prevent unstable blood pressure or heart rate. It is for adults who need a breathing tube placed quickly in the emergency room.
AntalyaAges 18 years+ - NCT07718971Enrolling by invitation
Whole-genome sequencing for unexplained medical conditions
This study uses whole-genome sequencing (a complete read of your DNA) to try to find a genetic cause for unexplained medical conditions. If you have a puzzling illness without a clear diagnosis, this test might give you answers.
Seattle, WashingtonAges 18–50 - NCT07722260Recruiting
Cough assistance for breathing tube weaning
This study tests whether special cough-aid techniques help adults on breathing tubes get off the ventilator faster. It may be an option for patients who need extra help coughing while they recover.
DamanhūrAges 18 years+ - NCT07716787Recruiting
Brain monitoring during breathing therapy in critically ill patients
This study looks at how a breathing machine setting (called PEEP) affects blood flow in the brain. If you or your loved one is in the ICU with a serious brain injury and is on a breathing machine, this trial could help doctors understand how to make breathing therapy safer for the brain.
Dongying, ShandongAges 18 years+ - NCT07710482Recruiting
Blood thinner for children getting a central line
This trial tests whether giving a blood thinner before placing a central line (a special IV) helps prevent clots in critically ill children. It could lower the risk of problems from the line.
Shibīn al Kawm, Menoufia GovernorateAges 1 month–18 years - NCT07707622Enrolling by invitation
Sepsis treatment study for ICU patients
This trial studies treatments for sepsis, a serious infection complication, in ICU patients. It aims to find better ways to care for critically ill patients with sepsis.
BeijingAges 18 years+ - NCT07694206Recruiting
Digital and blood tests for delirium in the ICU
This trial studies whether digital tools and blood tests can help detect delirium (sudden confusion) in ICU patients. If you or your loved one is in the ICU, this research could lead to better monitoring and care.
La Jolla, CaliforniaAges 65 years+ - NCT07656259Recruiting
Comparing breathing support methods in the heart ICU
This study compares different ways to support breathing in patients who need a ventilator in the cardiac intensive care unit. It aims to find the best approach for people with certain heart conditions, like cardiogenic shock or heart failure.
Rochester, MinnesotaAges 18 years+ - NCT03892174Recruiting
Removing inflammatory signals during heart surgery for endocarditis
This study tests whether removing certain inflammation signals (cytokines) can help people with severe heart infection (infective endocarditis) who are having heart surgery soon. It may help reduce harmful inflammation around the time of surgery, but it also has several medication and health-condition requirements.
BernAges 18 years+ - NCT07653321Enrolling by invitation
Kidney injury in critically ill patients
This study looks at acute kidney injury in patients who are very sick in the intensive care unit (ICU). It may help doctors better understand and manage kidney problems in these patients.
BeijingAges 18 years+ - NCT07643597Recruiting
Managing fluid removal in critically ill patients with acute kidney injury
This study looks at how to safely remove excess fluid from patients in the ICU who have sudden kidney failure and are on a special blood-filtering machine (CRRT). Researchers want to understand which patients have trouble tolerating fluid removal and how to prevent complications.
SalvadorAges 18 years+ - NCT07643467RecruitingPhase 4
Fluorescent dye test for kidney function in ICU patients
This trial tests a new fluorescent dye that may help doctors quickly check how well your kidneys are working while you are in the intensive care unit. It could provide a faster, less invasive way to monitor kidney health.
Lexington, KentuckyAges 18–65 - NCT07639359RecruitingPhase 2
Ketamine for depression in intensive care patients
This study tests whether low-dose ketamine infusions can reduce depressive symptoms in patients staying in the intensive care unit for at least 6 days. Ketamine is a medication that may work differently than standard antidepressants and could provide faster relief.
Jacksonville, FloridaAges 18–99 - NCT07642076RecruitingPhase 4
L-carnitine supplement for critically ill liver disease patients
This study tests whether adding L-carnitine (a naturally occurring compound) to standard care helps people with serious liver disease who are in the intensive care unit. L-carnitine may help the body use energy better and reduce complications from liver failure.
Shibīn al KawmAges 18 years+ - NCT07632716Recruiting
Blood marker to predict ICU patient outcomes
This study measures a specific blood protein (carbohydrate-deficient transferrin) when patients arrive at the hospital to see if it can predict how well they'll do in the intensive care unit. Understanding this marker might help doctors better plan care for critically ill patients.
ViennaAges 18 years+ - NCT06697470Recruiting
Ultrasound and fluid monitoring in the ICU
This study uses ultrasound and electrical impedance (skin electrodes) to track fluid balance in the muscles and tissues of ICU patients. It aims to see if these tools can help doctors better manage fluids during your stay.
Boussu, HainautAges 18 years+ - NCT06702813Recruiting
High-frequency vibration breathing treatment for ICU patients
This trial tests a device called MetaNeb that delivers high-frequency vibrations to help clear mucus and open collapsed air sacs in the lungs. It is designed for patients in the ICU who are awake, alert, and have trouble breathing or need extra oxygen.
Shanghai, Shanghai MunicipalityAges 1.5 years–80 years - NCT06021288Recruiting
Standard vs. lower dose dialysis for kidney failure in intensive care
This trial compares the usual dose of continuous dialysis with a lower dose to see if a lower dose is just as safe and effective for critically ill patients with sudden kidney failure.
MünsterAges 18 years+ - NCT07609095Recruiting
Testing pulse checks to assess blood circulation during emergency care
This study examines whether checking a patient's pulse at the wrist or other sites can help doctors quickly assess blood circulation problems during emergencies. The goal is to see if simple pulse checks match what more complex monitoring devices show, helping guide faster treatment decisions.
Stockholm, Stockholm CountyAges 18 years+ - NCT07611721Recruiting
Testing a glucose monitor in critically ill surgery patients
This study tests whether a wearable glucose monitor (Dexcom G7) works well in patients in intensive care after major abdominal surgery or organ transplant who need insulin therapy. The monitor measures blood sugar continuously to help doctors manage insulin doses more safely.
PragueAges 18 years+ - NCT07606495Recruiting
Better Sleep Care for Critically Ill Patients in ICU
This study tests whether personalized nighttime nursing care can improve sleep quality and health outcomes for conscious patients in the intensive care unit. Researchers believe better sleep may help patients recover faster and have better long-term health.
La Roche-sur-YonAges 18 years+
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Common questions
- Are there clinical trials for critically ill?
- Yes. Clin2 currently lists 336 recruiting critically ill studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.