Clinical trials · New York
Depression clinical trials in New York
We’re tracking 110 recruiting depression studies with a site in New York — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in New York
- NCT04621877Recruiting
Lay-led therapy for depression and anxiety at senior centers
This trial tests a structured, coach-led program called behavioral activation delivered in senior centers. It aims to improve symptoms of depression and generalized anxiety by teaching practical, step-by-step activity planning.
Brooklyn, New YorkAges 60 years+ - NCT07680153RecruitingPhase 4
Brain stimulation for bipolar depression
This study tests a non-invasive brain stimulation technique to see if it can improve mood in people with bipolar disorder who are currently experiencing depression. It aims to understand how the brain's mood circuits work.
New York, New YorkAges 18–70 - NCT05779761Recruiting
Brief coping exercises for high distress and worry
This study tests brief coping interventions to help people who feel very worried, stuck in negative thoughts, or overly self-critical. You would likely complete short activities using your smartphone and internet while the study checks how your distress changes over time.
New York, New YorkAges 18–65 - NCT07493317RecruitingPhase 2
Tocilizumab for depression with inflammation
This trial tests a medication called tocilizumab, which targets inflammation, to see if it can improve symptoms of major depression in people with signs of inflammation. You may be eligible if you have depression with a high monocyte count and significant loss of interest or pleasure.
New York, New YorkAges 18–70 - NCT07478393Recruiting
Emotion regulation therapy for worry and self-criticism
This trial tests a therapy that helps people manage emotions like worry and self-criticism. It takes place online, so you can join from home in New York.
New York, New YorkAges 18–65 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT07225088Recruiting
Mental health support for Latino cancer patients
This study tests a mental health intervention called DESCANSO to help Latino people with cancer who feel depressed, have trouble sleeping, or are very tired. You may join if you are a Latino adult with stage I-III solid tumor cancer, speak Spanish, and are currently or recently finished treatment.
Rockville Centre, New YorkAges 21–100 - NCT07218250Recruiting
One-time counseling for depression, anxiety, and distress in cancer
This study tests if a single counseling session can help reduce depression, anxiety, and distress in people with cancer. You may participate if you have been diagnosed with cancer and are waiting for ongoing counseling support.
Uniondale, New YorkAges 18 years+ - NCT07188467Recruiting
Stress and well-being support for international students
This study tests a self-help program called 'SH+' designed to reduce stress and improve well-being in international students at The New School. If you are an international student feeling at least mildly distressed, this program may help you develop coping skills.
Brooklyn, New YorkAges 18 years+ - NCT07143357Recruiting
Recovering together: support for cardiac arrest survivors and caregivers
This study tests a mind-body program to help cardiac arrest survivors and their caregivers cope with emotional distress after the event. It combines in-person and video sessions to improve well-being together.
New York, New YorkAges 18 years+ - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07076342RecruitingPhase 4
Glutamate receptors and cognitive behavioral therapy for insomnia
This study tests how a brain receptor called mGluR5 affects sleep and depression treatment. You may qualify if you have major depression with insomnia and are not currently on antidepressants.
Stony Brook, New YorkAges 18 years+ - NCT07048574Recruiting
Mood and behavior in children with cystic fibrosis
This study looks at mood and behavior in children with cystic fibrosis (CF) under 12. By following children over time, researchers hope to better understand and help with depression, anxiety, and behavior challenges that may come up.
Buffalo, New YorkAges 1.5 years–11 years - NCT06981598Recruiting
Preventing mental health issues with unit-based support
This trial studies how having behavioral health technicians (mental health support people) work directly in military units can help prevent psychological problems. It is for service members who are currently seeing one of these technicians, or for the technicians themselves who are embedded in a unit.
New York, New YorkAges 18 years+ - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Orangeburg, New YorkAges 14–20 - NCT06899165RecruitingPhase 2
Psilocybin therapy for inherited trauma
This trial tests whether psilocybin (a psychedelic substance) combined with therapy can help adult children of genocide survivors who experience symptoms of trauma, depression, or anxiety. The goal is to see if this approach can reduce the emotional impact of intergenerational trauma.
New York, New YorkAges 18 years+ - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70 - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
New York, New YorkAges 18–68 - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Rochester, New YorkAges 18–70 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
New York, New YorkAges 18–50 - NCT06689878Recruiting
Mobile therapy for anxiety and depression after stroke
This study tests if a mobile cognitive behavioral therapy app can help reduce anxiety and depression in people who have had a stroke. If you are between 40 and 79 and have ongoing feelings of worry or low mood after your stroke, this therapy might be a convenient option.
New York, New YorkAges 40–79 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
New York, New YorkAges 18–85 - NCT06455527Recruiting
Heart-guided brain stimulation for depression
This trial tests whether a non-invasive brain stimulation technique called tDCS, guided by your heart rate, can help improve depression symptoms. If you have mild to moderate depression and are not on medication, you may be eligible.
New York, New YorkAges 18–65 - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
Syracuse, New YorkAges 18 years+
Depression trials by city in New York
Where these studies are running in New York
Institutions with a site for the recruiting depression studies listed above.
- Icahn School of Medicine at Mount Sinai / Mount Sinai Hospital · 2 studies
- Memorial Sloan Kettering Cancer Center · 2 studies
- Memorial Sloan Kettering Nassau · 2 studies
- Memorial Sloan Kettering Westchester · 2 studies
- Mount Sinai Health System · 2 studies
- Stony Brook University: Dept of Psychiatry · 2 studies
- Teachers College, Columbia University · 2 studies
- Weill Cornell Medicine · 2 studies
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in New York?
- Yes. We're currently tracking 110 recruiting depression studies with a site in New York, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in New York?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in New York to take part?
- Not necessarily. These studies have a site in New York, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in New York regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.