Clinical trials
Drug Resistance clinical trials
Below are recruiting drug resistance clinical trials, each written for real people, not researchers. We’re tracking 118 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06794606Recruiting
Study for drug-resistant focal epilepsy
This trial looks at ways to diagnose and treat focal epilepsy that isn't controlled by medications. It includes patients with or without a visible brain lesion on imaging.
MilanAges 18 years+ - NCT06792799RecruitingEarly Phase 1
CAR-NK cells for B-cell autoimmune diseases
This early phase trial tests a new treatment made from immune cells (CAR-NK cells) that target and destroy overactive B cells. It may help people with lupus, certain kidney diseases, or nephrotic syndrome that hasn't responded to standard therapies.
Hangzhou, ZhejiangAges 3 years+ - NCT06432907Recruiting
Brain signal study during movement in epilepsy patients
This study records brain signals from electrodes already placed in your brain for medical reasons. It looks at how your brain controls movement, which could help develop future devices for people with paralysis.
MoscowAges 18–70 - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT06738771Recruiting
Antibiotic treatment for tough Pseudomonas infections
This study tests a specific antibiotic plan for adults with a hard-to-treat Pseudomonas infection that needs IV medicine. It aims to find the best way to treat these serious infections.
AmiensAges 18 years+ - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06553898RecruitingPhase 1
CAR-T cell therapy for hard-to-treat kidney disease
This trial tests a new CAR-T cell treatment for children and adults with steroid-resistant nephrotic syndrome (SRNS), a kidney condition that doesn't get better with standard medicines. The goal is to see if this therapy can help improve kidney function when other treatments have failed.
Hangzhou, ZhejiangAges 2 years+ - NCT06309251Recruiting
Ketogenic diet for children with epilepsy or other conditions
This trial studies how well a ketogenic diet works for children with hard-to-treat epilepsy or certain other diseases. It aims to see if the diet improves quality of life.
Milan, MIAges Up to 18 years - NCT06545214Recruiting
Breathing and arousal in drug-resistant epilepsy
This study looks at breathing problems during seizures in people with drug-resistant focal epilepsy. It aims to understand why some people stop breathing or have low oxygen during seizures, which could help prevent sudden death in epilepsy.
Bron, RhoneAges 18–55 - NCT06422923RecruitingPhase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes
This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.
Little Rock, ArkansasAges 18–75 - NCT06209645Recruiting
Personalized brain stimulation for stubborn nerve pain relief
This study tests a non-invasive, personalized brain stimulation technique to reduce nerve pain that has not responded to standard treatments. It may be a good option if you have had nerve pain for over a year and have already tried other pain medications without enough relief.
BronAges 18–80 - NCT05671718Recruiting
Nurse vs doctor treatment for drug-resistant tuberculosis
This trial compares a nurse-led plan versus a physician-led plan for treating new drug-resistant TB patients using an outpatient clinic approach. It may help by showing which care style works best and is safest for patients starting treatment close to home.
Pietermaritzburg, KwaZulu-NatalAges 18 years+ - NCT06059157Recruiting
Brain mapping with advanced MRI for epilepsy surgery
This trial uses special MRI scans to create a detailed map of the brain areas causing seizures, helping doctors plan SEEG surgery. It's for people with hard-to-control epilepsy who are already scheduled for SEEG.
BrusselsAges 3 years+ - NCT06022055Recruiting
studying brain tissue from epilepsy surgery
This study collects brain tissue from people with epilepsy that is not controlled by medication, during their planned surgery. Researchers will study the tissue to better understand epilepsy and improve treatments.
ParisAges 18 years+ - NCT05633056Recruiting
Testing TB medicines for people with drug-resistant TB and HIV
This trial studies a treatment plan for people who have both drug-resistant tuberculosis (TB) and HIV. It focuses on starting a specific TB medication (bedaquiline) and, if needed, HIV treatment soon after enrollment to see what approach works best.
Durban, KwaZulu-NatalAges 18 years+ - NCT05488340RecruitingPhase 2
Study drug for hard-to-treat bladder infection in women
This Phase 2 trial tests LBP-EC01 to treat a bladder infection (UTI) caused by drug-resistant E. coli. It may help by targeting the specific bacteria that make UTIs harder to cure with common antibiotics.
Fresno, CaliforniaAges 18–75 - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Birmingham, AlabamaAges 18–75 - NCT04451278Recruiting
Brain scan study to predict outcomes after epilepsy surgery in kids
This trial uses resting-state brain MRI (a scan while you’re not doing a task) to help predict how well children with hard-to-treat epilepsy may do after surgery. If you qualify, you would help researchers see whether the scan can forecast prognosis.
Paris, PARISAges 6–18 - NCT03268824Recruiting
Brain imaging study in drug-resistant focal epilepsy
This study uses MRI brain scans to see how “epileptic discharges” may affect brain connections in the developing brain. It also scans comparison participants without drug-resistant focal epilepsy to help researchers understand what is different.
ParisAges 1.5 years–16 years - NCT04923828Recruiting
Study drug resistance in very sick children with infections
This trial enrolls children in the pediatric intensive care unit (PICU) who have a severe infection. It aims to better understand germs and drug resistance so future treatments can be more effective.
Shanghai, Shanghai MunicipalityAges 1 month–16 years - NCT04798131Recruiting
Brain-scan training to reduce medication-resistant voices
This study uses brain scans (MRI) and real-time feedback to help train the brain to reduce frequent, distressing auditory hallucinations (hearing voices) in people with schizophrenia. If you qualify, you may try a structured neurofeedback program while researchers track changes in your symptoms.
LilleAges 18–60 - NCT03893916Recruiting
MEG vs EEG tests to find the epilepsy trigger before surgery
This study compares two brain tests—MEG and routine scalp EEG—to pinpoint where seizures start before surgery. It may help doctors choose the safest and most effective plan if you’re being considered for an epilepsy procedure.
BronAges 18–60 - NCT04065438Recruiting
Study of a blood-filter treatment for FSGS not responding to meds
This study looks at how well a specialized blood-filter device (the LIPOSORBER® LA-15) works for people with primary FSGS—especially when standard steroid and other medicines don’t work or can’t be tolerated. It may help reduce disease activity, particularly in people with kidney function that is still moderate or in those after kidney transplant.
Loma Linda, CaliforniaAges Up to 75 years - NCT03868293Recruiting
Low-intensity ultrasound for drug-resistant temporal lobe seizures
This pilot study tests whether low-intensity focused ultrasound can reduce seizures in adults whose temporal lobe epilepsy hasn’t improved with at least two anti-seizure medicines. You may be asked to track seizure timing and undergo brain imaging before and during the study.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for drug resistance?
- Yes. Clin2 currently lists 118 recruiting drug resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.