Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 328 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06105645Recruiting
Brain wave study for hard-to-treat epilepsy surgery
This study looks at special brain wave patterns called "fast-ripples" to help doctors better plan surgery for epilepsy that doesn't get better with medicine. It may improve how surgeons decide where to operate.
AmiensAges 18–65 - NCT06334952Recruiting
Personalized brain stimulation for hard-to-treat epilepsy
This study tests a personalized, non-invasive brain stimulation method called tDCS for people with drug-resistant epilepsy that starts in one part of the brain. It aims to reduce seizures in those who cannot have surgery or have not been helped by surgery.
BordeauxAges 9 years+ - NCT06205160Recruiting
Flexible brain electrodes for epilepsy surgery
This trial is testing new flexible brain electrodes during epilepsy surgery. These electrodes may help doctors map brain activity better than standard rigid ones. If you are having surgery for epilepsy caused by a brain lesion, you might be able to join.
UtrechtAges 18 years+ - NCT06202196Recruiting
Epilepsy education program for uncontrolled seizures
This study tests a program that teaches people with hard-to-control epilepsy how to better manage their condition. If you have seizures that continue despite treatment, or have been seizure-free for over a year but could use more support, this program may help you learn skills to improve your daily life.
MontpellierAges 18–60 - NCT05524493Recruiting
Brain scans for migraine, visual snow, or epilepsy symptoms
This study uses a very strong MRI brain scanner to better understand conditions like migraine, visual snow, or epilepsy that don’t fully respond to treatment. You may be able to join if you meet specific diagnosis and safety requirements for the scanner.
ZurichAges 18–65 - NCT06097195Recruiting
EEG test to help diagnose epilepsy after a first seizure
This trial studies a new way of analyzing EEG results to help doctors decide if a first suspected seizure was caused by epilepsy. If you had a first seizure and your EEG did not show clear signs of epilepsy, this test might improve your diagnosis.
TruroAges 18 years+ - NCT06063850RecruitingPhase 1/Phase 2
Gene therapy for adults with hard-to-control epilepsy
This trial tests a one-time gene therapy (AMT-260) for adults whose seizures start in one area of the brain (the temporal lobe) and aren't controlled by medication. The goal is to see if it's safe and reduces seizure frequency.
Birmingham, AlabamaAges 18–75 - NCT06022055Recruiting
studying brain tissue from epilepsy surgery
This study collects brain tissue from people with epilepsy that is not controlled by medication, during their planned surgery. Researchers will study the tissue to better understand epilepsy and improve treatments.
ParisAges 18 years+ - NCT05992402Recruiting
Brain training program for epilepsy surgery readiness
This study tests a cognitive training program called ReBOOT for adults with epilepsy who are eligible for surgery. The program is done online and aims to improve brain function before surgery.
Cleveland, OhioAges 18–60 - NCT05944692Recruiting
Tripolar EEG test during seizure monitoring
This study checks whether a new type of EEG recording (a brain wave test) can detect seizure activity in people with epilepsy. You may join if you are already scheduled for routine and video EEG testing (and possibly inpatient monitoring) as part of your clinical care, including a brain MRI.
Phoenix, ArizonaAges 6 years+ - NCT05794295Recruiting
Sleep study in people with focal epilepsy
This trial studies how sleep patterns relate to thinking and memory in people with focal epilepsy. It may help researchers understand what sleep changes could support brain function in epilepsy.
Sacramento, CaliforniaAges 18–40 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Phoenix, ArizonaAges 12 years+ - NCT05608408Recruiting
Preserving Memory in People With Epilepsy Using Brain Stimulation
This study tests a type of brain stimulation in people with epilepsy to see if it can help preserve memory. Researchers will compare memory and brain effects over time to understand whether stimulation changes memory outcomes.
Rochester, MinnesotaAges 18–65 - NCT05518578RecruitingPhase 2
Drug trial for hard-to-control focal epilepsy with brain scar
This Phase 2 trial tests SPN-817 in adults whose seizures are still not well controlled despite trying multiple seizure medicines. It targets people with a specific type of brain finding called focal cortical dysplasia and looks at safety/tolerability and seizure outcomes over several weeks.
Jacksonville, FloridaAges 18–70 - NCT05485649Recruiting
Pregnant people with epilepsy followed at a Toronto clinic
This study follows pregnant people who have epilepsy who were seen at a specific Toronto epilepsy clinic over a set time period. It aims to learn about health outcomes during pregnancy, which may help improve care and planning for future patients.
Toronto, OntarioAges Any age - NCT05503290Recruiting
Music sessions for pregnant people with epilepsy
This trial tests whether a guided music program (called “The Lullaby Project”) can be helpful during pregnancy for people with epilepsy. It focuses on participating in online musical sessions while you’re pregnant.
Toronto, OntarioAges 18 years+ - NCT05335187Recruiting
Electrode test during epilepsy surgery planning
This study tests a new “hybrid” type of electrodes placed inside the brain to better map where seizures start in people with difficult (drug-resistant) focal epilepsy. It may help doctors plan safer and more effective surgery, though it involves an invasive brain monitoring procedure.
Bern, Canton of BernAges 18 years+ - NCT05283811Recruiting
Brain recording during epilepsy care, while doing a memory task
This study listens to brain activity in people with epilepsy who already need electrodes placed inside the brain. Researchers want to understand how different parts of the brain respond while you complete simple thinking and memory-related tasks, which may help improve future treatments.
Los Angeles, CaliforniaAges 10–64 - NCT05290610Recruiting
Brain stimulation mapping during epilepsy surgery planning
This study uses a special kind of brain recording with stimulation to better map seizure activity while you are already having monitoring for epilepsy surgery. It may help doctors understand how to plan safer, more effective treatment.
Minneapolis, MinnesotaAges 18 years+ - NCT05082181Recruiting
Phone group support for adults with epilepsy and depression
This study tests whether telephone-based group support helps adults with epilepsy who also have elevated depressive symptoms. Sessions are recorded, and you’ll join by phone in English or Spanish.
New York, New YorkAges 18–99 - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Birmingham, AlabamaAges 1 day–6 months - NCT04451278Recruiting
Brain scan study to predict outcomes after epilepsy surgery in kids
This trial uses resting-state brain MRI (a scan while you’re not doing a task) to help predict how well children with hard-to-treat epilepsy may do after surgery. If you qualify, you would help researchers see whether the scan can forecast prognosis.
Paris, PARISAges 6–18 - NCT03268824Recruiting
Brain imaging study in drug-resistant focal epilepsy
This study uses MRI brain scans to see how “epileptic discharges” may affect brain connections in the developing brain. It also scans comparison participants without drug-resistant focal epilepsy to help researchers understand what is different.
ParisAges 1.5 years–16 years - NCT04788628Enrolling by invitation
Sound stimulation study for sleep and memory in epilepsy
This trial studies whether carefully timed sound (“auditory stimulation”) can change sleep patterns and memory in people with epilepsy. It may help researchers understand how to improve thinking and memory by adjusting how the brain sleeps.
Boston, MassachusettsAges 12–65
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 328 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.