Clinical trials
Epilepsy clinical trials
Below are recruiting epilepsy clinical trials, each written for real people, not researchers. We’re tracking 328 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01858285Recruiting
Genetics study for children with epilepsy
This study looks for genetic (inherited DNA) causes of epilepsy in children. It may help your family better understand what could be driving seizures, even if the cause isn’t known yet.
Boston, MassachusettsAges Any age - NCT04419272RecruitingPhase 4
Methylphenidate for thinking problems in adults with focal seizures
This trial studies whether methylphenidate (a stimulant medicine) can improve thinking and memory problems related to epilepsy. You may be kept on your usual seizure medicines, and your thinking will be tested over about 16 weeks.
Miami, FloridaAges 18 years+ - NCT03094312Recruiting
Check how a seizure-brain procedure affects thinking after surgery
This study looks at whether a special brain-recording procedure for difficult-to-control seizures changes a person’s memory, thinking, or other brain skills afterward. It may help doctors understand risks and plan care for people undergoing the procedure.
BronAges 18–65 - NCT03738072Recruiting
Test of brain electrical stimulation to plan epilepsy surgery
This study looks at how using a mild electrical stimulation in the brain may help doctors plan surgery for people with drug-resistant focal (partial) epilepsy. It happens during a hospital procedure to map the seizure areas (SEEG), so it may help improve where surgery targets.
ToulouseAges 12–65 - NCT03868293Recruiting
Low-intensity ultrasound for drug-resistant temporal lobe seizures
This pilot study tests whether low-intensity focused ultrasound can reduce seizures in adults whose temporal lobe epilepsy hasn’t improved with at least two anti-seizure medicines. You may be asked to track seizure timing and undergo brain imaging before and during the study.
Boston, MassachusettsAges 18 years+ - NCT02890641Recruiting
Study of brain signals and genes in hard-to-treat epilepsy
This study looks at genetic factors and brain electrical activity in children whose seizures are difficult to control with standard medicines. It also involves exams like MRI and possibly procedures under anesthesia, to better understand seizure causes and help future care.
ParisAges 3 months–25 years - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT02639325Recruiting
Seizure treatment study for people with brain tumors
This study looks at how a brain tumor-related seizure condition is handled in children and adults. It may be a good option if your seizures started soon after your brain tumor was found or is in the same brain area as your seizure symptoms.
Bethesda, MarylandAges 8–99 - NCT02107989Recruiting
MRI and brain scans before epilepsy surgery
This study collects noninvasive brain scan data (mainly MRI, sometimes MEG) from people being evaluated for focal epilepsy surgery, and from healthy volunteers. It aims to build reference “normal” brain images and improve how doctors plan and interpret epilepsy surgery evaluations.
Bethesda, MarylandAges 8–120 - NCT02151175Enrolling by invitation
Focused ultrasound to treat medication-resistant temporal lobe seizures
This trial tests a low-intensity focused ultrasound treatment aimed at reducing seizures caused by problems in one side of the hippocampus (a brain area involved in memory and seizures). It’s for people whose seizures have not responded to several seizure medicines and who have been offered a specific type of surgery.
Los Angeles, CaliforniaAges 18–60 - NCT00859794Enrolling by invitation
Study brain and movement functions in people with difficult epilepsy
This study looks at how the brain and body coordination work in people with epilepsy whose seizures do not fully respond to seizure medicines. Some participants may be people who are being evaluated for a possible epilepsy surgery because tests suggest they could benefit.
Great Neck, New YorkAges 5 years+ - NCT05459090Recruiting
Study of how brain “brakes” work in drug-resistant temporal epilepsy
This study looks at how the brain’s natural “braking” system works in people with drug-resistant temporal lobe epilepsy. It may help researchers better understand the condition in order to improve future treatments.
Pozzilli, IserniaAges Any age - NCT05600738Recruiting
Deep brain stimulation to treat epilepsy
This trial studies how adding or using deep brain stimulation devices affects people with epilepsy. It may help researchers understand which outcomes improve when these implanted devices are used.
Houston, TexasAges 18 years+ - NCT05534672RecruitingPhase 3
Rapamycin for drug-resistant seizures in tuberous sclerosis
This trial tests whether rapamycin (compared with a placebo) can reduce seizures caused by tuberous sclerosis complex (TSC) that have not been controlled by usual medicines. If you qualify, you may be helping doctors find a safer and more effective option for seizure control.
LodzAges 3 months–50 years - NCT06065852Recruiting
National registry for rare kidney diseases
This study creates a registry to collect health information from people with rare kidney diseases. It aims to improve understanding and future treatments by tracking patient experiences.
Bristol, South WestAges Any age - NCT05863910Recruiting
Real-world study of medical cannabis use in children
This study looks at how medical cannabis is used for children and teens in everyday life, by collecting information through online questionnaires. It may help doctors and families better understand which uses are common and how people experience them.
Winnipeg, ManitobaAges 3–17 - NCT07865546Recruiting
Advanced brain scans for epilepsy surgery planning
This study uses a very powerful MRI scanner to get detailed images of the brain. It aims to help doctors better understand and plan surgery for people with epilepsy that doesn't improve with medication.
Pisa, ItalyAges 6–65 - NCT04677751Recruiting
Testing acupuncture effects in people with an implanted seizure device
This study looks at how adding acupuncture may change seizure activity in people who already have an implanted RNS seizure monitor and stimulator. You might benefit by learning whether acupuncture helps with seizure patterns without changing your usual treatments.
Houston, TexasAges 15–60 - NCT06383689Recruiting
Improving comfort during epilepsy monitoring
This study tests if changing how we give placebo pills during long hospital monitoring can make the experience better and less stressful for people with epilepsy. The goal is to improve care for those who need this test before epilepsy surgery.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT07828496Recruiting
Brain training with neurofeedback for children after brain injury
This study helps children and teens improve thinking and memory after a brain injury or epilepsy using a brain-computer interface that gives feedback as they do mental exercises. It is a training program that may help strengthen brain function.
SingaporeAges 7–21 - NCT07822178Enrolling by invitation
How the brain understands faces during epilepsy monitoring
This study looks at how the brain understands faces by recording brain activity while you look at pictures. It uses the electrodes already placed in your brain during epilepsy monitoring, so no extra procedures are needed.
Los Angeles, CaliforniaAges 18 years+ - NCT07753681Recruiting
Chronic disease care in Zambia
This study helps improve care for people with long-term illnesses like diabetes or high blood pressure in Zambia. It aims to make sure you get regular check-ups and support.
Lusaka, Lusaka ProvinceAges Any age - NCT07750496RecruitingPhase 4
Stopping seizure medications in adults with epilepsy
This study looks at what happens when people with epilepsy stop their seizure medications. The goal is to see if it's safe to stop after being seizure-free for a while, and to help patients and doctors make better decisions.
Ann Arbor, MichiganAges 18 years+ - NCT07725601Recruiting
VNS dosing algorithm for epilepsy
This trial tests a new way to adjust the settings on a Vagus Nerve Stimulator (VNS) to better control seizures in people with epilepsy. It is for those who are already getting a VNS implanted to treat their seizures.
Augusta, GeorgiaAges 18–75
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Common questions
- Are there clinical trials for epilepsy?
- Yes. Clin2 currently lists 328 recruiting epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.