Clinical trials
Glioblastoma Multiforme (GBM) clinical trials
Below are recruiting glioblastoma multiforme (gbm) clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05052957RecruitingPhase 2
Stem cell rescue for glioblastoma
This trial tests whether using your own blood stem cells to support high-dose chemotherapy can help treat newly diagnosed glioblastoma, an aggressive brain cancer. It aims to improve outcomes for patients whose tumors have a specific genetic marker (unmethylated MGMT) and who have had surgery.
Cleveland, OhioAges 18 years+ - NCT04115761RecruitingPhase 2
ADCv01 added to standard care for newly diagnosed glioblastoma
This Phase 2 study tests ADCV01, given “on top of” other standard treatment, for newly diagnosed glioblastoma (grade 4 brain tumor). The goal is to see whether it helps patients live longer and safely manage tumor growth.
Taichung, Non-USAges 20–75 - NCT03213002RecruitingPhase 1/Phase 2
CAPTEM pills after brain radiation for newly diagnosed glioblastoma
This trial studies whether taking two chemotherapy pills (capecitabine and temozolomide) after the initial 6-week radiation-and-chemo phase can help people with newly diagnosed glioblastoma. It aims to test safety and early effectiveness right before the usual maintenance temozolomide phase.
New York, New YorkAges 18–74 - NCT06613841RecruitingEarly Phase 1
Brain tumor imaging study for glioblastoma patients
This study uses special PET scans (fluciclovine and FDG) and advanced MRI to create a detailed metabolic profile of glioblastoma. It may help doctors better understand your tumor before surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03005132Recruiting
Study for people with newly diagnosed brain cancer (GBM)
This trial looks at people with glioblastoma (GBM), a fast-growing brain tumor, to better understand it and how treatments might work. You may be able to join if you’re in a good general health range and have not had prior cancer chemotherapy.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07391215RecruitingPhase 1/Phase 2
Paxalisib for newly diagnosed glioblastoma after standard treatment
This trial tests a drug called paxalisib in people with a newly diagnosed aggressive brain tumor (glioblastoma) who have just finished standard radiation and chemotherapy. The goal is to see if adding paxalisib can help prevent the tumor from coming back by targeting a specific pathway in the cancer cells.
SuttonAges 16 years+ - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT03672721RecruitingPhase 1/Phase 2
Carboplatin with radiation for returning glioblastoma
This Phase 1/2 study tests a combination of carboplatin chemotherapy with radiation for glioblastoma that has come back. It aims to shrink or control the tumor after standard treatment has already been used.
Sherbrooke, QuebecAges 18 years+ - NCT06616727Enrolling by invitationPhase 1
CAR-T cell therapy for recurrent glioblastoma
This trial tests a new CAR-T cell treatment (SNC-109) for people with glioblastoma that has come back after initial treatment. The therapy uses your own immune cells, modified in a lab, to try to attack the tumor.
BeijingAges 18 years+ - NCT03596086RecruitingPhase 1/Phase 2
Study drug plus radiation and chemo for recurrent brain cancer
This Phase 1/2 study tests whether combining an HSV-tk “gene switch” treatment, valacyclovir tablets, focused radiation (SBRT), and chemotherapy can help people with recurrent glioblastoma or anaplastic astrocytoma. It may help shrink tumors or slow growth after standard treatments have already been tried.
Houston, TexasAges 18 years+ - NCT04765098RecruitingPhase 2
Tamoxifen or Etoposide for recurring brain tumor after prior treatment
This trial tests whether tamoxifen works as well as etoposide in people whose glioblastoma has come back after standard chemotherapy and radiation with temozolomide. It aims to find a better medication option for controlling the tumor after the first return.
Edmonton, AlbertaAges 18–65 - NCT05366179RecruitingPhase 1
Personalized CAR-T therapy for recurring brain tumor
This Phase 1 study tests a personalized immune-cell treatment (CAR-T) made from your own cells to attack a marker called B7-H3 on recurring glioblastoma. It may help shrink or control the tumor, but the main goal is to check safety and how the treatment works.
Chapel Hill, North CarolinaAges 18 years+ - NCT05281731Recruiting
Ultrasound-guided “sonobiopsy” for new brain tumor diagnosis
This trial tests a new way to take a tiny tissue sample from a suspected glioblastoma using ultrasound, to improve noninvasive detection. You may be able to get this targeted sample while you’re already planning surgery for tumor removal.
St Louis, MissouriAges 18 years+ - NCT05086497Recruiting
Personal TTFields device guided by imaging for brain tumor
This trial tests whether using a personalized TTFields device—placed based on imaging—can help treat adults with glioblastoma (GBM) after surgery and radiation. It’s designed for specific GBM genetic types and may help deliver therapy more precisely.
Philadelphia, PennsylvaniaAges 22 years+ - NCT04765514RecruitingPhase 2
Chemo with radiation versus chemo alone for older brain tumor patients
This trial compares two standard treatments for newly diagnosed glioblastoma (a serious brain cancer) in older and frail patients: chemo plus radiation versus chemo alone. It may help determine which approach works best and is safest for people in your age and health group.
Calgary, AlbertaAges 65 years+ - NCT01269853RecruitingPhase 1/Phase 2
Bevacizumab directly into brain arteries for recurrent brain tumors
This early-stage trial tests whether giving a targeted cancer medicine (bevacizumab) directly into brain arteries can help shrink or control certain recurrent (coming back) brain tumors. It may be an option if standard treatments are no longer working.
New York, New YorkAges 18 years+ - NCT05565326Recruiting
Testing MR-guided radiation checks for glioblastoma
This study tests how best to measure and track glioblastoma treatment while using MRI (a body scanner) to guide radiation. It may help improve how doctors assess the radiation response during therapy.
Zurich, Canton of ZurichAges 18 years+ - NCT05083754RecruitingPhase 1
New glioblastoma trial testing immune drug plus radiation
This Phase 1 study tests whether adding an immune therapy called retifanlimab to radiation (and a chemotherapy medicine called temozolomide, in some parts of the study) is safe and helpful for newly diagnosed glioblastoma patients after surgery with carmustine wafers. It aims to see how well this combination controls the cancer and what side effects are expected.
Baltimore, MarylandAges 18–100 - NCT04977375RecruitingPhase 1/Phase 2
Anti–PD-1 treatment plus focused radiation for recurrent glioblastoma
This trial tests a cancer-immunotherapy medicine (an anti–PD-1 antibody, similar to pembrolizumab) combined with precisely targeted radiation to treat glioblastoma that has come back or progressed. It may help your immune system recognize and attack the tumor while the radiation targets the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT05116137Enrolling by invitation
Exercise therapy to build muscle after glioblastoma
This trial studies whether a resistance (strength-building) exercise program can help survivors of glioblastoma keep or increase their muscle mass. If you are able to safely exercise, it may support recovery and overall strength after treatment.
Halifax, Nova ScotiaAges 18 years+ - NCT06810544RecruitingPhase 1/Phase 2
Study of TNG456 for tumors with MTAP loss
This trial tests a new drug called TNG456, alone or with another drug (abemaciclib), for people whose tumors have lost the MTAP gene. It aims to see if the combination can shrink tumors or slow their growth.
Scottsdale, ArizonaAges 18 years+ - NCT06717295Recruiting
Blood test to find cancer early and track treatment
This study uses a blood test that looks at your platelets and immune cells to find common cancers early, and for certain cancers, to monitor how well treatment is working.
RosarioAges 40–75 - NCT05956821RecruitingPhase 1/Phase 2
Study drug for young people with recurring brain glioma
This Phase 1/2 trial tests a study treatment for children and young adults under 22 whose brain glioma has come back or isn’t responding to prior treatment. It’s designed to see whether the treatment is safe and effective for shrinking tumors in this situation.
Miami, FloridaAges 1–21 - NCT03603405RecruitingPhase 1/Phase 2
Test vaccine and radiation with chemotherapy for new brain tumor
This trial studies a gene-based treatment (HSV-tk) given with radiation and chemotherapy for people newly diagnosed with glioblastoma or anaplastic astrocytoma. It may help the new brain tumor respond better to standard treatments, though risks and benefits are still being tested.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for glioblastoma multiforme (gbm)?
- Yes. Clin2 currently lists 50 recruiting glioblastoma multiforme (gbm) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioblastoma multiforme (gbm) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioblastoma multiforme (gbm) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.