Clinical trials
Heart Failure NYHA Class II clinical trials
Below are recruiting heart failure nyha class ii clinical trials, each written for real people, not researchers. We’re tracking 159 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Little Rock, ArkansasAges 50 years+ - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Tucson, ArizonaAges 18–85 - NCT07204834Enrolling by invitation
Physical activity program for heart failure
This study tests a home-based physical activity program for people with heart failure. The program is designed to be safe and easy to follow, using a smartphone app to guide you, and may help you feel stronger and more active.
GranadaAges 18 years+ - NCT07192341Recruiting
Heart failure drug for people with artificial heart valves
This trial tests a drug called sacubitril/valsartan to see if it helps people who have both a prosthetic heart valve and heart failure with a weak heart pump. The goal is to improve heart function and symptoms.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT06734065Recruiting
Heart failure monitoring with a non-invasive lung fluid sensor
This trial tests a new device that measures fluid in your lungs without needles or surgery. It may help your doctor manage heart failure better, especially if you've been in the hospital recently or have symptoms like shortness of breath.
FlenAges 18 years+ - NCT06831825RecruitingPhase 1
Gene therapy for heart failure recovery trial
This trial tests a gene therapy injected into the heart to help it recover after a previous heart attack. It may be an option for people with stable heart failure who are not eligible for standard procedures like stents or bypass surgery.
Houston, TexasAges 18–79 - NCT07164911Recruiting
Heart failure rehab: who benefits most?
This study looks at what helps people with heart failure get the most out of a cardiac rehab program. It aims to find out which patients improve the most after completing phase II cardiac rehab.
CorbieAges 40–75 - NCT03180320Recruiting
Exercise program for chronic heart failure with confidence building
This trial studies whether a specific gentle exercise routine (Baduanjin, “eight-silken-movement”) plus skills to build self-confidence can help people with chronic heart failure. It’s meant for people who are stable and can do prescribed exercise testing and sessions.
Guangzhou, GuangdongAges 18 years+ - NCT07069738Recruiting
New pacemaker vs standard cardiac therapy for heart failure
This study tests a newer type of pacemaker that paces the heart's left bundle branch area, compared to the usual cardiac resynchronization therapy. It is for people with heart failure who need a combined pacemaker-defibrillator (CRT-D) and have a specific heart rhythm pattern (left bundle branch block) with reduced pumping strength.
Huntsville, AlabamaAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Birmingham, AlabamaAges 18–99 - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT07023536Recruiting
Heart rehab program from home for chronic heart failure
This trial tests a cardiac telerehabilitation program for people with chronic heart failure. It is designed to see if doing rehab at home using digital tools helps improve health and quality of life.
SalernoAges 18 years+ - NCT06989580Recruiting
Heart failure monitoring with a wireless implant
This trial is testing a special monitor (BIOMONITOR) that tracks your heart function and sends data wirelessly to your doctor. It aims to help manage heart failure by catching early signs of trouble so you can get treatment sooner.
GenkAges 18 years+ - NCT06961929Recruiting
Heat and Heart Failure Study
This study looks at how heat affects the body in people with stable heart failure compared to healthy volunteers. It may help researchers understand how to better manage heart failure in daily life.
Dallas, TexasAges 45 years+ - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06455878Recruiting
Mobile app for weight loss in heart failure patients
This trial tests a mobile app that helps you track your diet to manage your weight. It is designed for people with heart failure who are overweight and have recently been in the hospital for their condition.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06885164Recruiting
Remote heart monitoring for heart failure patients
This trial tests whether remote monitoring of heart function can help manage heart failure. It may be an option if you have symptoms like shortness of breath or fatigue (NYHA class II or higher) and are between 18 and 90 years old.
Aalborg, DenmarkAges 18–90 - NCT06661876Recruiting
Heart radiation therapy for heart failure
This trial tests if a low dose of radiation to the heart can help people with advanced heart failure feel better and improve heart function. It is for patients whose heart failure is stable but severe, and who are already on the best medications.
LeuvenAges 18 years+ - NCT06517186Recruiting
Heart failure study with preserved pumping function
This study looks at how the heart muscle works in people with a type of heart failure where the heart pumps normally but doesn't fill properly. It aims to understand the cause better, which could lead to new treatments.
Chicago, IllinoisAges 30 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT06424288RecruitingPhase 3
Testing vicadrostat plus empagliflozin for heart failure
This study tests whether adding a new study drug called vicadrostat to the standard heart failure medicine empagliflozin helps people with heart failure. It may be a good option if you have heart failure with preserved pumping function and are not already on a medicine called an MRA.
Mobile, AlabamaAges 18 years+ - NCT06306573Enrolling by invitation
CardioMEMS heart pressure monitor study in Medicare patients
This study looks at how well the CardioMEMS heart pressure monitor works for people with heart failure who are on Medicare. It gathers real-world information to see if the sensor helps improve health outcomes.
Atlanta, GeorgiaAges 18 years+ - NCT06258447Recruiting
CardiAMP bone marrow cell therapy for heart failure
This trial tests a new treatment using your own bone marrow cells to help your heart pump better. It's for people with heart failure after a heart attack whose heart function is moderately reduced.
Clearwater, FloridaAges 21–90
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Common questions
- Are there clinical trials for heart failure nyha class ii?
- Yes. Clin2 currently lists 159 recruiting heart failure nyha class ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.