Clinical trials
Heart Failure, Systolic clinical trials
Below are recruiting heart failure, systolic clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05677100Recruiting
Aortix device for acute heart failure
This trial is testing a small pump placed in the aorta to help the kidneys remove extra fluid when standard IV diuretics aren't working well enough for severe heart failure. It may help you if you're hospitalized and still very congested (swollen, fluid buildup) despite strong water pills.
Phoenix, ArizonaAges 21 years+ - NCT05647213RecruitingPhase 1
Skin biopsy study of stem-cell therapy for congenital heart disease
This early study takes a small skin sample to make a personalized type of heart stem cells in the future. It is testing whether this approach is safe and feasible for people with complex single-chamber congenital heart disease and advanced heart failure.
Rochester, MinnesotaAges 18–40 - NCT05568069Recruiting
Study of defibrillator implants for non-ischemic weak heart
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
High Wycombe, BuckinghamshireAges 18 years+ - NCT05585125RecruitingPhase 4
Testing an informed approach for older adults with HFpEF
This study looks at an “informed” approach to help manage HFpEF (a type of heart failure) in people age 65 and older. It checks whether a structured plan and monitoring are practical and safe for you over time.
New York, New YorkAges 65 years+ - NCT05519046Recruiting
Test a heart pacing treatment for Chagas-related heart failure
This study looks at a heart treatment called cardiac contractility modulation in people with Chagas heart disease who have moderate symptoms and weak heart pumping. It aims to see whether this therapy improves heart function and related outcomes in the right patients.
São Paulo, São PauloAges 18–75 - NCT05276219RecruitingPhase 4
Vasodilators or diuretics for acute heart failure
This trial compares two treatments for sudden heart failure symptoms like severe shortness of breath. It aims to see whether opening blood vessels or using a water pill works better to relieve congestion and improve breathing.
Copenhagen, CopenhagenAges 18 years+ - NCT02973633RecruitingEarly Phase 1
Heart failure MRI brain-wave images after heart trouble
This early-phase study uses a special MRI scan to look at the heart in people with heart failure (and related heart changes). It aims to see whether these MRI results can better characterize heart disease and help doctors understand what’s going on.
Charlestown, MassachusettsAges 18–85 - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT04396899RecruitingPhase 1/Phase 2
Stem cell heart patch for advanced heart failure
This early-phase study tests a lab-made heart tissue (“engineered myocardium”) placed surgically to help the heart work better in people with advanced heart failure. It mainly checks safety first, and also looks for signs the patch can improve heart function in selected patients.
Göttingen, Lower SaxonyAges 18–80 - NCT03984591Enrolling by invitationPhase 4
Compare spironolactone vs eplerenone for heart failure patients
This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.
CopenhagenAges Any age - NCT07704424Recruiting
Testing a heart pump for severe right heart failure
This trial is evaluating a new temporary heart pump called CorVad for people who develop severe right heart failure shortly after heart surgery, a heart attack, or a heart transplant. The pump is designed to help the right side of the heart pump blood when medications are not enough.
Hefei, AnhuiAges 18 years+ - NCT07695090RecruitingPhase 2
Lumacaftor for improved brain blood flow in heart failure
This trial tests if lumacaftor, a medication used in cystic fibrosis, can improve blood flow to the brain in people with stable heart failure. It might help if you have heart failure with reduced pumping function and low brain blood flow.
Toronto, OntarioAges 18 years+ - NCT07692256RecruitingPhase 2
Empagliflozin for heart failure in children
This trial tests if empagliflozin, a diabetes medicine that also helps the heart, can improve symptoms in children with heart failure. It may help kids with severe symptoms or high levels of a heart stress marker called BNP.
Cairo, Cairo GovernorateAges 1 month–18 years - NCT05802849RecruitingPhase 4
Oral acetazolamide for worsening heart failure
This trial tests whether taking acetazolamide by mouth can help prevent or improve worsening (decompensation) of heart failure after you needed IV water pills (diuretics). It’s mainly for adults with a recent heart-failure flare and specific heart/lab signs, while carefully excluding certain low blood pressure, kidney issues, and electrolyte or acid–base problems.
SamaraAges 18 years+ - NCT07572032RecruitingPhase 4
Delayed heart failure medications after fixing the cause
This study tests whether starting two heart failure medications later, after a procedure to fix the heart's problem, is safe and helpful. It aims to see if waiting a bit can still improve heart function and quality of life.
Daegu, DaeguAges 18 years+ - NCT06783166RecruitingPhase 2/Phase 3
Comparing two medications for acute heart failure with fluid buildup
This trial tests if dapagliflozin or acetazolamide works better for people hospitalized with heart failure who have extra fluid in their body (congestion). The study will compare how well each medication helps remove fluid when used with standard IV diuretics.
Al MansurahAges 18 years+ - NCT07402239Recruiting
Heart failure therapy and monitoring device study
This trial tests a device that treats and monitors heart failure. It may help people with chronic heart failure and reduced heart function who still have symptoms despite standard treatments.
Fuzhou, FujianAges 18 years+ - NCT07397650RecruitingPhase 4
Early finerenone for heart failure in hospital
This trial tests if starting finerenone early helps patients hospitalized with heart failure who have symptoms like shortness of breath or swelling. It aims to see if the drug is safe and effective when given soon after admission.
Handa, Aichi-kenAges 18 years+ - NCT07325942Recruiting
Low vs high volume high-intensity interval training for heart failure
This study compares two different types of high-intensity interval exercise programs (one shorter, one longer) in people with chronic heart failure. It aims to see which program improves heart health and daily function more.
Cairo, Giza GovernorateAges 18 years+ - NCT07243769Recruiting
Comparing exercise types for heart rehab
This trial compares core, aerobic, and combined exercise in patients doing phase II cardiac rehab. It aims to find which type works best for heart recovery.
TaipeiAges 18 years+ - NCT07108231Recruiting
Breathing muscle training for hospitalized heart failure patients
This trial tests whether training the muscles you use to breathe can help people recover while in the hospital for heart failure. If you are stable enough, you may be able to join.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT02638142Recruiting
Testing IV diuretic treatment for sudden worsening heart failure
This trial studies how an IV (into-the-vein) “water pill” (furosemide/loop diuretic) works in people whose heart failure has suddenly gotten worse. It may help doctors find the best way to reduce fluid-related symptoms like breathing trouble and swelling.
Chioggia, VeneziaAges 18 years+ - NCT06364644Recruiting
Reducing heart failure risk in low-income adults with diabetes
This study looks at how low income and diabetes together raise the risk of heart failure. It offers a program to help you manage your health and reduce that risk.
Baltimore, MarylandAges 30–70 - NCT05392764RecruitingPhase 3
SGLT2 medicine for high-risk people after sudden worsening heart failure
This Phase 3 trial tests whether starting an SGLT2 inhibitor early in the hospital can improve outcomes for people at high risk after acute (sudden) heart failure. If you qualify, you would be randomized to receive the study medicine or standard care, started within 12 hours of admission.
Anjo, Aichi-kenAges 20 years+
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Common questions
- Are there clinical trials for heart failure, systolic?
- Yes. Clin2 currently lists 180 recruiting heart failure, systolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, systolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, systolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.