Clinical trials
Heart Failure, Systolic clinical trials
Below are recruiting heart failure, systolic clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04405583Recruiting
Follow-up study for a heart device in heart failure patients
This study follows people with chronic heart failure to see how well an implanted device (called the Occlutech AFR) works and whether it is safe over time. It may help doctors better understand who benefits and how to manage treatment safely.
BesançonAges 18 years+ - NCT06332391Recruiting
Paced heart rate increase for heart conditioning
This trial tests whether a special pacing pattern can strengthen your heart's pumping ability. You may qualify if you have heart failure with a low ejection fraction and already have a pacemaker or defibrillator with an atrial lead.
Iowa City, IowaAges 18–120 - NCT07572955Recruiting
Understanding Fluid Changes in Hospitalized Heart Failure
This study observes patients admitted to the hospital with heart failure that has suddenly worsened. Researchers will use daily ultrasound scans of your lungs to track fluid buildup and understand how the heart failure progresses during your hospital stay.
Rochester, MinnesotaAges 18 years+ - NCT07492524Recruiting
Village doctor telehealth program for heart failure with atrial fibrillation
This trial tests a program where village doctors use telehealth to support patients who have both atrial fibrillation (an irregular heartbeat) and heart failure (when the heart doesn't pump well). It aims to improve their health and quality of life.
Yancheng, DongtaiAges 65–80 - NCT07372040RecruitingPhase 2
Adding a Water Pill for Heart Failure in the Hospital
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
TantaAges 18 years+ - NCT07047547Recruiting
Vericiguat study for kidney disease and heart failure patients
This trial tests how a medication called vericiguat works in people with both chronic kidney disease and heart failure. It aims to see if the drug helps manage these conditions together.
Guangzhou, GuangdongAges 18–80 - NCT06285760Recruiting
Acetazolamide for fluid removal in acute heart failure
This study tests whether adding acetazolamide (a different type of water pill) to your current treatment helps remove extra fluid from your body more effectively when you are in the hospital for heart failure.
MadridAges Any age - NCT05411614Recruiting
Testing two heart procedures for atrial fibrillation in heart failure
This study compares two different ablation procedures (treatments that target heart rhythm triggers) for people with atrial fibrillation and reduced heart pumping. It aims to see which approach works best and is safest for improving your heart rhythm when you also have heart failure.
ChertseyAges 18 years+ - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT07349797Recruiting
Transdermal GFR system to check kidney function in heart failure
This trial tests a sensor placed on the skin to measure kidney function in adults with heart failure. It may help understand how well the kidneys are working without repeated blood draws.
New York, New YorkAges 18 years+ - NCT07337577Recruiting
Heart failure study using AI messages to improve treatment
This study tests whether messages from a large language model (a type of AI) can help doctors prescribe the right medicines for heart failure. It may help people with heart failure get the best guideline-recommended treatments.
Boston, MassachusettsAges 18–85 - NCT07029906Recruiting
Testing if beta-blocker side effects are due to expectations
This study tests whether some side effects from beta-blockers are caused by your expectations (the nocebo effect) rather than the drug itself. If you have heart failure and stopped a beta-blocker due to symptoms, this study may help understand your experience and potentially find better ways to manage it.
LondonAges 18 years+ - NCT06105580Recruiting
Pacing methods for heart failure with wide QRS
This trial compares two ways to pace the heart in people with heart failure and a wide QRS (a sign the heart's electrical signals are slowed). The goal is to see which method better reduces the risks of death, heart failure hospitalization, or needing a heart transplant.
BarcelonaAges 18 years+ - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT06243653Recruiting
Heart microvessel function test for heart failure recovery
This trial looks at how tiny blood vessels in the heart affect improvement in heart pumping strength for people with heart failure. It tests whether a special procedure during heart catheterization can predict recovery.
SeoulAges 19 years+ - NCT03398369Recruiting
Imaging study to guide heart failure device treatment
This study uses advanced heart imaging to better understand heart function in people who may benefit from a cardiac resynchronization therapy (CRT) device. It aims to find ways to improve how doctors choose treatment and tailor care.
Charlottesville, VirginiaAges 20–90 - NCT06336746Recruiting
Heart function during steep head-down position in robotic surgery
This study looks at how your heart performs during robotic surgery when you are placed in a steep head-down position. It may help doctors better understand how to keep you safe during the procedure.
Karlstad, Värmland CountyAges 18 years+ - NCT05427370Recruiting
Compare bypass or stent treatment in weak heart patients
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
Los Angeles, CaliforniaAges 18 years+ - NCT05230732Recruiting
Test a nerve-stimulation approach for heart inflammation
This trial studies a nerve-stimulation treatment to affect inflammation and blood vessel function in people with systolic heart failure. If you qualify, it may help improve how your heart and blood vessels work.
Oklahoma City, OklahomaAges 18–85 - NCT06630923RecruitingPhase 3
Preventing kidney worsening with IV albumin in heart failure
This trial tests if giving a medicine called albumin through a vein can help prevent kidney function from getting worse in people hospitalized with worsening heart failure and liver problems. It may be an option if other treatments haven't worked.
Alexandroupoli, EvrosAges 18–95 - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Alexander City, AlabamaAges 50–99 - NCT07560436RecruitingPhase 2
Stents for Heart Failure With Normal Pumping
This trial tests whether placing stents in coronary arteries helps patients with heart failure who still have a strong-pumping heart. The study aims to see if improving blood flow to the heart reduces symptoms and improves quality of life.
LondonAges 18 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT05582044Recruiting
Exercise using leg suction for heart failure with preserved function
This study tests whether a specific lower-body exercise method using negative pressure (leg suction) can improve symptoms and heart-related function in people with heart failure with preserved ejection fraction (HFpEF). You may also be offered screening if you are a healthy person, to compare results.
Kelowna, British ColumbiaAges 40 years+
Hear when a new Heart Failure, Systolic trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for heart failure, systolic?
- Yes. Clin2 currently lists 181 recruiting heart failure, systolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, systolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, systolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.