Clinical trials
Heart Failure, Systolic clinical trials
Below are recruiting heart failure, systolic clinical trials, each written for real people, not researchers. We’re tracking 185 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05292716Recruiting
MitraClip for advanced heart failure with leaky mitral valve
This trial studies whether the MitraClip procedure can improve outcomes for people with advanced heart failure caused by significant leakage of the mitral valve. It focuses on people who still have severe symptoms and poor quality of life despite the best available heart medications.
Brescia, LombardyAges 18–90 - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT05568069Recruiting
Study of defibrillator implants for non-ischemic weak heart
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
High Wycombe, BuckinghamshireAges 18 years+ - NCT05573997Recruiting
Testing new ultrasound measures of heart muscle function in heart failure
This study looks at whether a special kind of heart ultrasound can better measure how well the heart muscle works in people admitted with heart failure. It may help doctors understand heart function using clearer ultrasound “biomarkers” soon after hospital admission.
Thessaloniki, Central MacedoniaAges 18 years+ - NCT05632432Recruiting
Heart tissue grafts to help the heart after surgery
This trial tests whether transplanting tiny heart “micrografts” from the left heart chamber area can improve heart function after cardiac surgery. It is meant for people with weakened heart pumping and heart failure symptoms despite medicine.
Helsinki, UusimaaAges 18–75 - NCT05647213RecruitingPhase 1
Skin biopsy study of stem-cell therapy for congenital heart disease
This early study takes a small skin sample to make a personalized type of heart stem cells in the future. It is testing whether this approach is safe and feasible for people with complex single-chamber congenital heart disease and advanced heart failure.
Rochester, MinnesotaAges 18–40 - NCT05933083Recruiting
In-person vs telehealth heart rehab comparison study
This study compares whether heart rehabilitation done in person or by telehealth (video/phone) works as well for people with certain heart conditions. It may help you and others choose the safest and most effective way to receive cardiac rehab.
San Francisco, CaliforniaAges 18 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06253104Recruiting
Tracking muscle changes in acute heart failure
This study measures how thigh muscles change in people hospitalized with severe heart failure. It aims to understand muscle loss during this condition and how it relates to recovery.
Boston, MassachusettsAges 18–100 - NCT06270498RecruitingPhase 4
Oral iron for heart failure: exercise and quality of life study
This study tests whether an oral iron supplement (a pill called sucrosomial iron) can help people with heart failure who have low iron feel better, have more energy, and walk farther. Participants will take the iron pill or a placebo (a pill without the active ingredient) for a period and will do exercise tests and answer questionnaires to see how they improve.
Pisa, TuscanyAges 18 years+ - NCT06286423RecruitingPhase 4
Colchicine for acute heart failure with low pumping strength
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
Charlottesville, VirginiaAges 18 years+ - NCT06324682Recruiting
Comparing heart pacemaker types for better treatment
This trial looks at different ways to pace the heart (like left, right, or both sides) to see which works best for people who need a pacemaker. If you have a heart condition requiring a pacemaker, this study may help find the safest and most effective option for you.
Ferrara, FEAges 18 years+ - NCT06062966RecruitingPhase 1
Study of anakinra for advanced heart failure on inotrope therapy
This study tests whether a drug called anakinra can improve how your heart responds to inotrope therapy (medicines that help your heart pump). It is for people with advanced heart failure who are already on a steady dose of these medicines and have signs of inflammation. The goal is to see if blocking inflammation helps your heart work better.
Richmond, VirginiaAges 21 years+ - NCT06331208Recruiting
Mechanisms of Lung Blood Vessel Problems in Heart Failure
This study looks at how heart failure affects blood vessels in the lungs. If you have heart failure with reduced pumping ability and need a heart catheterization, you may be able to join.
PragueAges 18 years+ - NCT06348498RecruitingPhase 1
Jia Shen tablets for chronic heart failure study
This trial tests a Chinese herbal tablet, Jia Shen, to see how the body processes it and if it helps people with chronic heart failure. It is for adults with weak heart pumping and stable medication use.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06576752Recruiting
Home heart failure management after hospital discharge
This trial tests a program to manage heart failure at home after you leave the hospital. It aims to safely adjust your medications to optimal doses while you recover at home.
Lørenskog, AkershusAges 18 years+ - NCT05519046Recruiting
Test a heart pacing treatment for Chagas-related heart failure
This study looks at a heart treatment called cardiac contractility modulation in people with Chagas heart disease who have moderate symptoms and weak heart pumping. It aims to see whether this therapy improves heart function and related outcomes in the right patients.
São Paulo, São PauloAges 18–75 - NCT06671015Recruiting
Comparing breathing support methods after a breathing tube is removed in people with heart failure
This study compares two types of breathing support—a high-flow nasal cannula and noninvasive ventilation—to see which one better prevents the need for re-inserting a breathing tube in people with systolic heart failure who are at high risk for breathing problems after the tube is removed.
New Haven, ConnecticutAges 18 years+ - NCT06675448Recruiting
Best practices for heart failure with leaky mitral valve
This trial compares two treatment approaches for people with heart failure and a leaky mitral valve (mitral regurgitation). It aims to find which strategy leads to better outcomes. You may be eligible if your heart function is reduced and you have symptoms despite standard treatments.
Falls Church, VirginiaAges 18–99 - NCT07687186RecruitingPhase 3
Qishen Yiqi pills for chronic heart failure
This trial tests whether Qishen Yiqi Dripping Pills, a Chinese herbal medicine, can help people with chronic heart failure caused by coronary heart disease. It is for adults who have been on stable heart failure treatment for at least two weeks.
Bozhou, AnhuiAges 18–80 - NCT06783335Recruiting
Cordella sensor for chronic heart failure
This trial studies a small sensor placed in the lung artery to help manage chronic heart failure. It compares patients who get the sensor to those who receive standard care, to see if the sensor improves outcomes.
Naperville, IllinoisAges 18 years+ - NCT06805253Recruiting
Heart recovery after surgery for leaky aortic valve
This trial studies how well the heart's main pumping chamber (left ventricle) recovers after surgery to fix a leaky aortic valve. It is for people who also have a leaky mitral valve and an enlarged left ventricle, and who are having their first planned valve surgery.
MoscowAges 18 years+
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Common questions
- Are there clinical trials for heart failure, systolic?
- Yes. Clin2 currently lists 185 recruiting heart failure, systolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, systolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, systolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.