Clinical trials
Heart Failure, Systolic clinical trials
Below are recruiting heart failure, systolic clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06253104Recruiting
Tracking muscle changes in acute heart failure
This study measures how thigh muscles change in people hospitalized with severe heart failure. It aims to understand muscle loss during this condition and how it relates to recovery.
Boston, MassachusettsAges 18–100 - NCT07185100Recruiting
Finding early heart failure in at-risk adults across Germany
This study uses heart MRI scans to find unrecognized heart failure in people who have risk factors like diabetes, kidney disease, high blood pressure, or obesity but haven't been diagnosed with heart failure yet. If you join, you will help researchers learn how common hidden heart failure is and take an important step for your own heart health.
BerlinAges 40–69 - NCT07057323Enrolling by invitation
Coronary sinus reducer for heart failure with preserved pumping function
This trial tests a device placed in a heart vein to improve symptoms in people whose heart pumps normally but still causes shortness of breath and fatigue. The device may help relieve pressure in the heart and improve daily life.
Rochester, MinnesotaAges 18 years+ - NCT07050706Enrolling by invitation
Heart failure and protein levels in the blood
This trial checks if a protein called PRMT5 in the blood is linked to heart function in people with heart failure. It compares healthy volunteers and those with heart failure to see if this protein can help understand the condition better.
Shenzhen, GuangdongAges 18 years+ - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT04962711Recruiting
Risk-guided plan to prevent heart failure after cancer treatment
This trial tests whether a personalized, risk-based heart care plan can help prevent heart failure in people who had certain cancer treatments. It focuses on monitoring and guiding treatment, using heart ultrasound results and other health factors.
Melbourne, VictoriaAges 40–85 - NCT07008365RecruitingPhase 3
Measuring belly pressure and ultrasound to guide fluid removal in heart failure
This trial tests whether using belly pressure and bedside ultrasound can help doctors better manage fluid removal (decongestion) in people hospitalized with heart failure. The goal is to see if this approach leads to better outcomes.
ZaragozaAges 18–100 - NCT06965504Recruiting
Heart failure medications with an Impella heart pump for cardiogenic shock
This study tests whether a special heart pump (Impella 5.5) can help patients with severe heart failure (cardiogenic shock) safely start and increase their heart failure medications. The goal is to see if this approach can help the heart recover and improve outcomes.
Tampa, FloridaAges 18–80 - NCT06969560Recruiting
Wearable monitor for heart failure in kids
This study tests a wearable patch (like a smart bandage) that tracks your heart health at home. It's for children and teens with heart failure to help doctors monitor them without frequent hospital visits.
Edmonton, AlbertaAges 8–18 - NCT06805253Recruiting
Heart recovery after surgery for leaky aortic valve
This trial studies how well the heart's main pumping chamber (left ventricle) recovers after surgery to fix a leaky aortic valve. It is for people who also have a leaky mitral valve and an enlarged left ventricle, and who are having their first planned valve surgery.
MoscowAges 18 years+ - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06783335Recruiting
Cordella sensor for chronic heart failure
This trial studies a small sensor placed in the lung artery to help manage chronic heart failure. It compares patients who get the sensor to those who receive standard care, to see if the sensor improves outcomes.
Naperville, IllinoisAges 18 years+ - NCT06736574RecruitingPhase 3
Study of omecamtiv mecarbil for chronic heart failure with very weak heart pump
This study tests an investigational medicine (omecamtiv mecarbil) for people with chronic heart failure and very low pumping strength. It looks at whether the drug can help prevent heart failure events or the need for stronger treatments.
Alexander City, AlabamaAges 18–85 - NCT06595290Recruiting
Faster medication increase for heart failure with weak pumping
This trial tests a new, faster way to increase heart failure medications during a hospital stay, aiming to get patients on the right doses sooner. It is for people with weak heart pumping (ejection fraction 40% or less) who are currently in the hospital for heart failure and are on low doses of standard medications.
Long Xuyen, An GiangAges 18–75 - NCT06671015Recruiting
Comparing breathing support methods after a breathing tube is removed in people with heart failure
This study compares two types of breathing support—a high-flow nasal cannula and noninvasive ventilation—to see which one better prevents the need for re-inserting a breathing tube in people with systolic heart failure who are at high risk for breathing problems after the tube is removed.
New Haven, ConnecticutAges 18 years+ - NCT06576752Recruiting
Home heart failure management after hospital discharge
This trial tests a program to manage heart failure at home after you leave the hospital. It aims to safely adjust your medications to optimal doses while you recover at home.
Lørenskog, AkershusAges 18 years+ - NCT06552637Recruiting
Diaphragm stimulation for heart failure
This trial tests a device that stimulates your diaphragm (the muscle that helps you breathe) while you have heart failure. It may help improve your breathing and heart function. The study is for people with moderate heart failure symptoms whose heart pumps less blood than normal.
Indianapolis, IndianaAges 18 years+ - NCT05029570Recruiting
Heart rate control for permanent atrial fibrillation and heart failure
This trial studies whether a strategy to regularize (control) heart rate can improve outcomes in people who have permanent atrial fibrillation and heart failure. It focuses on people with recent heart-failure hospitalization and checks several heart, kidney, and health-condition limits to keep the study safe.
Madrid, MadridAges 18 years+ - NCT04950218Recruiting
Study risks of heart problems in people with psoriasis
This study asks adults with psoriasis about factors that may be linked to heart problems. It aims to better understand who is at higher risk, which could help guide future prevention and care.
Hellerup, CopenhagneAges 18 years+ - NCT06270498RecruitingPhase 4
Oral iron for heart failure: exercise and quality of life study
This study tests whether an oral iron supplement (a pill called sucrosomial iron) can help people with heart failure who have low iron feel better, have more energy, and walk farther. Participants will take the iron pill or a placebo (a pill without the active ingredient) for a period and will do exercise tests and answer questionnaires to see how they improve.
Pisa, TuscanyAges 18 years+ - NCT04438213RecruitingPhase 2
Ertugliflozin for chronic heart failure with added urine testing
This Phase 2 trial studies whether the medication ertugliflozin can help people with chronic heart failure. You would be asked to follow a set treatment plan and complete repeated urine (and other) testing to see how your body responds.
New Haven, ConnecticutAges 18 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for heart failure, systolic?
- Yes. Clin2 currently lists 181 recruiting heart failure, systolic studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure, systolic trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure, systolic trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.