Clinical trials · Texas
Heart Failure With Preserved Ejection Fraction clinical trials in Texas
We’re tracking 17 recruiting heart failure with preserved ejection fraction studies with a site in Texas — including Early Phase 1, Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Texas
- NCT07547540RecruitingPhase 1
Study of an investigational drug for heart failure
This study tests an experimental drug called LY3971297 to see if it can help people with chronic heart failure. It aims to find out if the drug is safe and if it improves heart function.
Houston, TexasAges 18–65 - NCT05838287RecruitingPhase 4
Pioglitazone for heart failure with preserved pumping in type 2 diabetes
This trial tests whether pioglitazone (a diabetes medicine) helps people who have type 2 diabetes and a specific type of heart failure where the heart pumps normally. It may improve heart failure symptoms and function in carefully selected patients.
San Antonio, TexasAges 30–70 - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Dallas, TexasAges 50–99 - NCT07219511RecruitingPhase 1
Safety study of VS-041 for heart failure with preserved pumping strength
This trial tests an investigational drug called VS-041 to see if it's safe and helps people with a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may be an option if you are 50 or older and have stable heart failure symptoms.
Tomball, TexasAges 50 years+ - NCT06560762RecruitingPhase 1
Study of a new drug for heart failure with preserved pumping ability
This trial tests an investigational drug for people with a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug can improve symptoms and quality of life.
Dallas, TexasAges 18 years+ - NCT06979362RecruitingPhase 2
Study of CDR132L for heart failure with preserved pumping function
This trial tests if CDR132L can improve heart structure and function in people with a type of heart failure where the heart pumps normally but is stiff and thickened. It may help if you have heart failure with preserved ejection fraction and a thickened heart muscle.
Amarillo, TexasAges 40–84 - NCT06678841Recruiting
Pacing therapy for heart failure with preserved pumping ability
This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
Dallas, TexasAges 40 years+ - NCT05057806RecruitingEarly Phase 1
Testing how ketones may affect heart benefits in type 2 diabetes
This early study looks at people with type 2 diabetes and certain types of heart failure to see whether changes in “ketones” relate to heart benefits. It may help researchers understand who could benefit most from treatment-related metabolism changes.
San Antonio, TexasAges 18–80 - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Austin, TexasAges 18 years+ - NCT05723679Recruiting
Breathing-targeted program to improve function in HFpEF
This trial studies a breathing-focused treatment to help people with HFpEF (a type of heart failure) feel and function better. It may help improve daily activity by addressing breathing limits that commonly come with this condition.
Dallas, TexasAges 55–90 - NCT06061549RecruitingPhase 1
Gene therapy for stiff heart failure (preserved EF)
This trial tests a one-time gene therapy for people with heart failure who still have normal pumping strength (preserved ejection fraction). It aims to improve how heart cells handle calcium, which may help the heart relax better and ease symptoms.
Dallas, TexasAges 50 years+ - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Weslaco, TexasAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Austin, TexasAges 18 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Houston, TexasAges 40–85 - NCT07223242RecruitingPhase 2/Phase 3
Tailored exercise training for heart failure with preserved pumping strength
This trial tests a personalized exercise program to help people with a type of heart failure called HFpEF. You may qualify if your heart still pumps well but you have trouble being active, and you are willing to use a phone app and exercise regularly.
Dallas, TexasAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Conroe, TexasAges 18–99 - NCT06930495Enrolling by invitation
Weight loss and heart failure with normal pumping strength
This study tests whether weight loss treatments can improve muscle and blood vessel function in people with a specific type of heart failure (HFpEF) who also have obesity. It may help if you have heart failure with a normal ejection fraction and a high BMI.
Dallas, TexasAges 18 years+
Heart Failure With Preserved Ejection Fraction trials by city in Texas
Where these studies are running in Texas
Institutions with a site for the recruiting heart failure with preserved ejection fraction studies listed above.
- University of Texas Southwestern Medical Center · 8 studies
- Austin Heart · 2 studies
- East Texas Cardiology PA · 2 studies
- Houston Methodist Hospital · 2 studies
- Texas Cardiac Arrhythmia Research Foundation · 2 studies
- University of Texas Health Science Center at San Antonio · 2 studies
- Amarillo Medical Specialists LLP
- Amarillo, TX
What taking part in a heart failure with preserved ejection fraction study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart Failure With Preserved Ejection Fraction trials in other states
Common questions
- Are there heart failure with preserved ejection fraction clinical trials in Texas?
- Yes. We're currently tracking 17 recruiting heart failure with preserved ejection fraction studies with a site in Texas, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart failure with preserved ejection fraction study in Texas?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Texas to take part?
- Not necessarily. These studies have a site in Texas, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart failure with preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart failure with preserved ejection fraction studies open in Texas regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.