Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT06342492Recruiting
Comparing two pacing methods for lead failure in heart failure
This study compares two ways to fix a failed lead in a heart failure pacemaker: placing a new lead on the outside of the heart or using the heart's own electrical system. It follows people whose CRT lead stopped working and was replaced, to see which method works best.
Overland Park, KansasAges 18 years+ - NCT07636343Recruiting
Eccentric Training for Heart Failure Recovery
This trial tests a special type of strength training (eccentric exercise, where muscles lengthen under load) for people with heart failure who have reduced pumping ability. The goal is to improve your exercise capacity and heart function safely.
EdegemAges Any age - NCT07631156RecruitingPhase 4
Safely Reducing Heart Failure Medications After Recovery
This study tests whether patients whose heart function has fully recovered after surgery or a heart procedure can safely reduce or stop their heart failure medications. Researchers will carefully monitor whether gradually lowering these medicines is safe and maintains heart health.
Daegu, DaeguAges 19 years+ - NCT07626879Recruiting
Ring Blood Pressure Device Compared to Standard 24-Hour Monitoring
This study tests whether a new ring-shaped blood pressure device works as well as the standard 24-hour ambulatory blood pressure monitor in people with heart failure. If the ring device is accurate, it could offer a simpler, more convenient way to track blood pressure at home.
DaeguAges 19 years+ - NCT07595809Recruiting
Diet and exercise for heart failure with weak heart pumping
This study tests whether combining a healthy eating plan (DASH diet) with supervised exercise can help people with heart failure where the heart doesn't pump strongly enough. The goal is to see if these lifestyle changes improve heart function and symptoms.
Zabrze, Silesian VoivodeshipAges 30 years+ - NCT07601724Recruiting
How fluid buildup affects sleep apnea in heart failure
This study looks at how excess fluid in the body affects sleep apnea (pauses in breathing during sleep) in people hospitalized with heart failure. Researchers will measure sleep apnea before and after treatment to reduce the fluid, which may help doctors better manage both conditions together.
JerusalemAges 18 years+ - NCT06516562Recruiting
Heart failure study in Vietnam: following patients' health over time
This study follows people with heart failure in Vietnam to understand their health and treatment over time. It does not test a new drug—just collects information to improve care.
Ho Chi Minh CityAges 18 years+ - NCT07581587Recruiting
Breathing Exercises and Brain Function in Heart Failure
This study tests whether special breathing exercises—done alone or while doing a mental task—can improve memory and thinking skills in people with heart failure. Researchers want to see if training your breathing muscles helps your brain work better.
Istanbul, FatihAges 40 years+ - NCT07569640RecruitingPhase 3
Heart failure combination pill study
This study tests a single pill that combines several heart failure medicines to see if it helps people with a weakened heart pump feel better and stay out of the hospital. It is being done in Sri Lanka and may offer a simpler way to take multiple medications.
Kandy, Central ProvinceAges 18 years+ - NCT06249932RecruitingPhase 4
Empagliflozin for heart failure and end-stage kidney disease
This trial tests whether empagliflozin, a medication for heart failure, can help people who also have end-stage kidney disease and are on dialysis. It aims to see if the drug improves heart function in this group.
Hsinchu, TaiwanAges 20 years+ - NCT07547540RecruitingPhase 1
Study of an investigational drug for heart failure
This study tests an experimental drug called LY3971297 to see if it can help people with chronic heart failure. It aims to find out if the drug is safe and if it improves heart function.
Detroit, MichiganAges 18–65 - NCT07543562RecruitingPhase 3
Selenium supplement for heart failure patients
This study tests whether taking selenium (a mineral supplement) helps heart failure patients feel better and live longer. Researchers will follow patients over time to see if selenium reduces symptoms and hospital visits.
OsloAges 18 years+ - NCT07539766Recruiting
Obesity Surgery Study to Prevent Heart Problems
This study follows people with obesity who are having weight-loss surgery to see if the surgery can help prevent a specific type of heart problem (HFpEF) that sometimes develops in people carrying excess weight. Researchers will track your heart health and metabolism before and after surgery.
Heerlen, LimburgAges 35 years+ - NCT07518030Recruiting
Telemedicine support for heart failure medication adjustment
This study tests whether remote check-ins via phone or video can help safely increase heart failure medications to target doses. You'll use a device to share weight, blood pressure, and heart rate with your doctor, who will adjust your medicines based on how you're doing.
PiacenzaAges 18 years+ - NCT07513883RecruitingPhase 4
Reducing Heart Failure Medications When Your Heart Recovers
This study tests whether patients whose heart failure has improved can safely reduce some of their medications. If your heart function has recovered significantly and stayed stable, this trial explores whether you can gradually lower doses of heart failure drugs while staying healthy.
GenkAges 18 years+ - NCT07492498Recruiting
Village doctor telehealth to prevent heart failure in af
This study tests whether regular support from village doctors using telehealth (remote check-ins) can help prevent heart failure in people with atrial fibrillation, a common heart rhythm problem. The goal is to catch early signs and keep your heart healthier.
Yancheng, DongtaiAges 65–80 - NCT07492524Recruiting
Village doctor telehealth program for heart failure with atrial fibrillation
This trial tests a program where village doctors use telehealth to support patients who have both atrial fibrillation (an irregular heartbeat) and heart failure (when the heart doesn't pump well). It aims to improve their health and quality of life.
Yancheng, DongtaiAges 65–80 - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT07467668Recruiting
Iron infusion for heart failure patients with low iron
This trial tests whether giving intravenous iron to adults hospitalized with heart failure and low iron levels helps improve their health. You may be eligible if you have heart failure with reduced pumping function and low iron stores.
Pleasanton, CaliforniaAges 18 years+ - NCT07460531Recruiting
Physical activity and heart health in chronic heart failure
This study looks at how physical activity affects heart outcomes in people with chronic heart failure. If you have a pedometer or activity tracker, you may be able to join.
Munich, BavariaAges 18 years+ - NCT07447908Recruiting
Understanding worsening heart failure after leaving the hospital
This study monitors heart failure patients after a hospital stay or urgent clinic visit to better understand the signs of worsening heart failure. It may help researchers find ways to predict and prevent future exacerbations.
Newmarket, OntarioAges 18 years+ - NCT07442448Enrolling by invitationPhase 4
Study of Finerenone for heart and kidney health in diabetes
This trial tests a medication called Finerenone to see if it can improve heart structure and function in people with both diabetic kidney disease and heart failure. If you have type 2 diabetes, kidney problems, and heart failure with preserved pumping function, this study may explore a new treatment option for you.
TaipeiAges 18 years+ - NCT07430553Recruiting
Comparing pacemakers for better heart function in heart failure
This trial compares three types of advanced pacemakers (cardiac resynchronization therapy devices) to see which works best for improving heart function and reducing abnormal heart rhythms in people with heart failure.
London, Greater LondonAges 18 years+
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Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 182 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.