Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06278844Recruiting
Pacing method to improve exercise in heart failure
This study tests a new way to pace the heart in people with heart failure who need a pacemaker. It aims to see if this pacing method helps them exercise more easily.
Edegem, AntwerpAges 18 years+ - NCT06286423RecruitingPhase 4
Colchicine for acute heart failure with low pumping strength
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
Charlottesville, VirginiaAges 18 years+ - NCT06299436Recruiting
Heart muscle function testing in right heart failure
This trial studies how the right side of the heart works in people with heart failure. It uses special monitoring to understand muscle function and may help doctors find better ways to treat right heart failure.
Baltimore, MarylandAges 18–90 - NCT07695090RecruitingPhase 2
Lumacaftor for improved brain blood flow in heart failure
This trial tests if lumacaftor, a medication used in cystic fibrosis, can improve blood flow to the brain in people with stable heart failure. It might help if you have heart failure with reduced pumping function and low brain blood flow.
Toronto, OntarioAges 18 years+ - NCT06331208Recruiting
Mechanisms of Lung Blood Vessel Problems in Heart Failure
This study looks at how heart failure affects blood vessels in the lungs. If you have heart failure with reduced pumping ability and need a heart catheterization, you may be able to join.
PragueAges 18 years+ - NCT06342492Recruiting
Comparing two pacing methods for lead failure in heart failure
This study compares two ways to fix a failed lead in a heart failure pacemaker: placing a new lead on the outside of the heart or using the heart's own electrical system. It follows people whose CRT lead stopped working and was replaced, to see which method works best.
Overland Park, KansasAges 18 years+ - NCT06344910Recruiting
Study on messaging heart failure doctors in Amsterdam
This trial tests if sending reminders to doctors can improve care for people with heart failure with reduced pumping function. It aims to help patients get the best treatments.
AmsterdamAges 18 years+ - NCT06359938Recruiting
RSA pacing study for heart failure patients after bypass surgery
This trial tests a special pacing method called RSA pacing that may help the heart work better after bypass surgery. It is for people with heart failure and a weakened heart muscle who are scheduled for bypass surgery.
CardiffAges 22 years+ - NCT06384963Recruiting
Pacing after bypass for heart failure patients
This trial tests a special pacing therapy that uses your natural breathing rhythm to improve heart function after coronary artery bypass surgery. It may help people with weak heart muscles recover better after surgery.
Adelaide, South AustraliaAges 22 years+ - NCT06409585Recruiting
Heart muscle disease imaging study for scarring
This study uses advanced imaging (PET/MR or PET/CT) to look at scarring (fibrosis) in the heart muscle. It is for people with various heart muscle diseases, including heart failure with preserved pumping, thickened heart muscle, high blood pressure-related heart damage, heart inflammation, and others.
Edinburgh, ScotlandAges 30–90 - NCT06423599RecruitingPhase 2/Phase 3
Weight Loss for Obesity and Heart Failure
This study tests whether weight loss from a medication can improve how you feel, move, and how well your heart works. It's for people who have both obesity and heart failure with reduced pumping strength.
CopenhagenAges 18 years+ - NCT06455878Recruiting
Mobile app for weight loss in heart failure patients
This trial tests a mobile app that helps you track your diet to manage your weight. It is designed for people with heart failure who are overweight and have recently been in the hospital for their condition.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06479876Recruiting
Home-based heart rehab for heart failure
This study tests a home-based cardiac rehabilitation program for people with heart failure. It aims to help you become more active and manage your condition safely at home.
Nashville, TennesseeAges 18 years+ - NCT06516562Recruiting
Heart failure study in Vietnam: following patients' health over time
This study follows people with heart failure in Vietnam to understand their health and treatment over time. It does not test a new drug—just collects information to improve care.
Ho Chi Minh CityAges 18 years+ - NCT06518694RecruitingPhase 3
Can you stop beta-blockers after heart failure recovery?
This trial tests whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers. It aims to see if staying on the medication is still needed or if stopping is just as safe.
Paris, IDFAges 18 years+ - NCT06595290Recruiting
Faster medication increase for heart failure with weak pumping
This trial tests a new, faster way to increase heart failure medications during a hospital stay, aiming to get patients on the right doses sooner. It is for people with weak heart pumping (ejection fraction 40% or less) who are currently in the hospital for heart failure and are on low doses of standard medications.
Long Xuyen, An GiangAges 18–75 - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT06689111Recruiting
Heart resynchronization method study for patients with LBBB and heart failure
This study compares two ways to resynchronize the heart's pumping in people with heart failure and a specific heart block (LBBB). It uses special ultrasound imaging to see which method works better for improving heart function.
Pátrai, GreeceAges 18–90 - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Orange, CaliforniaAges 18 years+ - NCT06008197RecruitingPhase 3
A study of finerenone for hospitalized heart failure patients
This trial tests a medication called finerenone to see if it helps people hospitalized for heart failure live longer and have fewer heart-related problems. It may be an option for those with a certain type of heart failure where the heart's pumping strength is mildly reduced or normal.
Birmingham, AlabamaAges 18 years+ - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Houma, LouisianaAges 18–85 - NCT07688863Enrolling by invitation
Comparing breathing muscle training methods for heart failure
This trial compares two different types of breathing muscle training to see which works better for people with heart failure and weak breathing muscles. You may join if you have heart failure with reduced pumping ability and are stable overall.
Viña del Mar, ValparaisoAges 18 years+ - NCT07447908Recruiting
Understanding worsening heart failure after leaving the hospital
This study monitors heart failure patients after a hospital stay or urgent clinic visit to better understand the signs of worsening heart failure. It may help researchers find ways to predict and prevent future exacerbations.
Newmarket, OntarioAges 18 years+ - NCT06726109Recruiting
FOCUS study on acute heart failure
This trial is studying patients admitted to the hospital for acute heart failure. It will collect information to better understand and treat people with low heart pumping strength (ejection fraction less than 40%) and fluid retention.
Genk, BelgiumAges Any age
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Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 182 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.