Clinical trials
Heart Failure With Reduced Ejection Fraction clinical trials
Below are recruiting heart failure with reduced ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 182 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06819618Recruiting
Predicting heart failure outcomes with machine learning
This trial uses machine learning to analyze data from a smartwatch to predict how heart failure progresses. It may help doctors better understand your condition and tailor treatments.
Goettigen, Lower SaxonyAges 18 years+ - NCT07416279Recruiting
Can tiny bubbles replace catheters for heart pressure checks?
This trial tests if tiny ultrasound contrast bubbles can measure heart pressure, possibly replacing the need for catheter tubes. If you're already getting a heart catheterization, you may be able to join.
LondonAges 21–81 - NCT07405944RecruitingPhase 4
Vericiguat for improving heart function in heart failure
This study tests a medicine called vericiguat (a pill) to see if it can improve the heart's shape and function in people with heart failure and a weakened pump. You would keep taking your usual heart medications plus the study drug.
IzolaAges 18 years+ - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT05942287Recruiting
Weight and weight loss study in heart failure with weak pumping
This study looks at how obesity and weight loss affect people living with heart failure where the heart pumping strength is reduced. It uses heart imaging (MRI) to measure the heart and may help clarify what weight changes do for symptoms and heart function.
Jersey, JerseyAges 18–85 - NCT07352891Recruiting
Digital remote management vs. usual care for heart failure
This trial tests whether using a remote monitoring platform to help manage medications improves outcomes in people with heart failure and reduced pumping function. It compares this approach to standard follow-up care.
BeijingAges 18 years+ - NCT06774014Recruiting
Heart failure and diabetes: cell study
This study looks at how cells talk to each other in people who have both diabetes and heart failure. It may help doctors understand these conditions better.
Leeds, West YorkshireAges 18 years+ - NCT06851949RecruitingPhase 2
Vsling device for ventricular repair in heart failure
This trial tests a new device called Vsling, which is placed inside the heart to help reshape the main pumping chamber (left ventricle) in people with heart failure. It may improve your heart's strength and reduce symptoms like shortness of breath.
Be’er Ya‘aqovAges 18 years+ - NCT07335510Recruiting
Baroreflex therapy for heart failure patients
This trial tests a device that stimulates a nerve in your neck to help your heart pump better. It is for people with heart failure and a weak heart pump who still have symptoms despite taking medications.
San Francisco, CaliforniaAges 18 years+ - NCT05828719Recruiting
Compare heart stent treatment vs medicines for weak heart function
This study looks at whether opening blocked heart arteries with a stent (a PCI procedure) works better than staying on heart medicines for people with weakened pumping function and certain types of heart failure. It may help patients by testing which approach best improves outcomes over time.
SeoulAges 19 years+ - NCT06826963Recruiting
Eccentric exercise for older adults with heart failure and muscle loss
This study tests whether a special type of exercise (eccentric, or lengthening, exercises) can help older adults with heart failure who also have muscle loss. It aims to see if the exercise is safe and improves strength and function.
Verona, VeronaAges 65–85 - NCT07283666Enrolling by invitation
Heart care quality program for AFib and heart failure
This trial aims to improve care for people with atrial fibrillation (a type of irregular heartbeat) or heart failure with reduced pumping strength. It focuses on making sure you get the right treatments based on your health history and recent visits to a heart doctor.
New York, New YorkAges 18–90 - NCT07275931Recruiting
Digital support program for heart failure patients
Researchers in Sweden are testing a digital support program to help patients with heart failure manage their condition at home. If you qualify, you'll use a smartphone or computer-based program that may offer tips, tracking, and help from a care team.
Linköping, Östergötland CountyAges 18 years+ - NCT07272902Recruiting
Atrial fibrillation treatment: Ablation vs. medication
This trial compares two ways to treat atrial fibrillation in people with heart failure where the heart's pumping strength is still normal. You'll either get a procedure called ablation to restore normal rhythm or medication to control your heart rate. The goal is to see which approach works better for people like you.
Halifax, Nova ScotiaAges 18 years+ - NCT07259512RecruitingPhase 4
Ramipril once or twice a day for kidney and heart health
This trial tests whether taking ramipril once or twice daily better protects kidney function in people with both chronic kidney disease (stages 3-5, not on dialysis) and heart failure with low pumping strength. It aims to find the best dosing schedule to help both organs.
Kartasura, Central JavaAges 18 years+ - NCT06758128Recruiting
Genes and immunity in worsening heart failure
This study looks at how your genes and immune system affect heart failure. Researchers want to understand why some people have flare-ups (exacerbations) and how the body responds.
San Giovanni Rotondo, FoggiaAges 18 years+ - NCT07253909Enrolling by invitation
Arm function in heart failure with ICD or CRT devices
This study looks at how well people with heart failure and certain heart devices (ICD or CRT) can use their arms and hands. It aims to understand if these devices affect upper body function.
Ankara, SamanpazarıAges 18 years+ - NCT07252310Enrolling by invitationPhase 4
Smartphone app to find best beta blocker dose for heart failure
This study uses a smartphone app to test how different beta blocker doses work best for you. It's for older adults with stable heart failure who want to fine-tune their treatment.
New York, New YorkAges 65 years+ - NCT07247032Recruiting
Heart failure management with remote monitoring
This trial tests whether remote monitoring of your implanted heart device can help your doctors better manage your heart failure. It is for people with certain types of pacemakers or defibrillators who are willing to share their device data remotely.
ParisAges 18–85 - NCT07243119Enrolling by invitationPhase 4
Heart failure study with adenosine scans to predict recovery
This trial tests whether high-dose adenosine during a heart scan can better predict how well your heart muscle might recover, compared to standard dosing. The information could help doctors personalize treatment for people newly diagnosed with heart failure and a low ejection fraction.
HerningAges 18–100 - NCT05583773RecruitingPhase 4
Herbal medicine for heart failure with lower pumping strength
This trial tests SHengXIaN-QuYu decoction (an herbal treatment) in people with symptomatic heart failure and reduced pumping function. It looks to see whether the herbal formula is safe and helpful for heart failure symptoms and heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Tucson, ArizonaAges 18–85 - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT07218627RecruitingPhase 1
Study of an investigational medicine for heart failure
This study tests an experimental medicine called NNC0537-1482 for people with heart failure. It aims to see if the medicine helps improve symptoms and heart function.
LondonAges 40–75
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Common questions
- Are there clinical trials for heart failure with reduced ejection fraction?
- Yes. Clin2 currently lists 182 recruiting heart failure with reduced ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure with reduced ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure with reduced ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Mildly Reduced Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Acute Heart Failure
- Chronic Heart Failure
- Congestive Heart Failure
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.