Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06535529RecruitingPhase 3
Comparing Two Water Pills for Worsening Heart Failure
This study compares two medicines—acetazolamide and dapagliflozin—to see which works better at removing extra fluid in people hospitalized for worsening heart failure. It may help decide the best treatment for fluid overload.
CairoAges 18 years+ - NCT07689760Enrolling by invitation
AI to Predict Hospital Readmission in Heart Failure
This study uses artificial intelligence (AI) to predict when people with heart failure might need to go back to the hospital. It's designed for patients who are already in a telemonitoring program and use an iPhone to track their health.
EnschedeAges 18 years+ - NCT07278583Recruiting
Heart failure telemonitoring program evaluation
This trial looks at how well a telemonitoring program works for people with heart failure. It checks if the eligibility rules used by the French health authority make sense.
Clermont-FerrandAges 18 years+ - NCT06024746RecruitingPhase 3
Finerenone plus SGLT2i for hospitalized heart failure
This trial tests whether adding two heart medicines together (finerenone and an SGLT2 inhibitor) helps people who are in the hospital for heart failure recover better. It may be an option for you if you are currently hospitalized and your heart stress markers are high.
Fairhope, AlabamaAges 18 years+ - NCT07499661Recruiting
Study of blood clots in the lungs with heart failure
This study looks at whether a blood clot in the lungs (pulmonary embolism) is a hidden cause in patients who are hospitalized for acute heart failure. It involves additional imaging tests to find a clot if present, which could change your treatment.
AgenAges 18 years+ - NCT04196842Recruiting
Heart failure precision medicine study using heart tests and blood tests
This study looks at how “personalized” (precision) treatment planning for heart failure may work, using results from heart imaging (echocardiogram) or a blood test called B-type natriuretic peptide. You may join if you have heart failure and can follow frequent study check-ins.
Sacramento, CaliforniaAges 21 years+ - NCT04707261RecruitingPhase 4
Testing how dapagliflozin affects anemia in heart failure
This trial studies whether dapagliflozin (a heart-failure medicine) can improve anemia in people with heart failure. It may help explain why some patients feel better and how anemia changes when this medicine is used.
Xiangtan, HunanAges 18–100 - NCT05562167RecruitingPhase 2
Inorganic nitrate plus exercise for heart failure performance
This Phase 2 study tests whether taking inorganic nitrate can improve exercise ability and heart-function symptoms in people with heart failure with reduced pumping. It also checks whether the treatment is safe when combined with an exercise program.
St Louis, MissouriAges 19–79 - NCT05955456Recruiting
Check ways to spot early heart failure
This study looks for people who may be developing heart failure early, using heart imaging and related checks. If you fit the risk pattern, the results may help find heart failure sooner in similar people.
Manchester, Greater ManchesterAges 50 years+ - NCT06061627Recruiting
LOT-CRT vs standard CRT for heart failure with NICD
This study compares a newer pacing therapy (LOT-CRT) to standard cardiac resynchronization therapy (BiVP) for people with heart failure who have a specific type of electrical delay in the heart (NICD). The goal is to see if the newer method works better.
Nanjing, JiangsuAges 18–80 - NCT06207383Recruiting
Comparing heart treatments for atrial fibrillation and heart failure
This study compares two treatments for people with atrial fibrillation and heart failure: one is a procedure to fix the irregular heartbeat (AF ablation), and the other involves a different type of pacing for the heart. It aims to find which approach helps you feel better and stay out of the hospital.
GrazAges 60 years+ - NCT06427343RecruitingPhase 4
IV iron: low dose vs high dose for heart failure with low iron
This study compares two different doses of IV iron (low vs high) to see which works better for people with heart failure and low iron levels. It may help you feel less tired and breathe easier.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06578078RecruitingPhase 3
Best heart failure care for older patients with kidney disease
This study tests the best way to manage heart failure in older adults who also have kidney problems and high potassium levels. It compares different treatment strategies to see which one is safest and most effective.
Alcorcón, MadridAges 70 years+ - NCT06578793Recruiting
Catheter plus vein ablation for atrial fibrillation with heart failure
This trial tests whether adding a vein ablation to standard catheter ablation helps people with persistent atrial fibrillation and heart failure. It aims to find the best treatment to improve heart function and reduce symptoms.
Changsha, HunanAges 18–80 - NCT06991257RecruitingPhase 2
Study of PF-07328948 for adults with heart failure
This trial tests a new medicine, PF-07328948, for adults with heart failure to see if it can improve symptoms and daily life. It is for people who have had heart failure for at least 3 months and can walk without too much difficulty.
Beverly Hills, CaliforniaAges 18–79 - NCT07029906Recruiting
Testing if beta-blocker side effects are due to expectations
This study tests whether some side effects from beta-blockers are caused by your expectations (the nocebo effect) rather than the drug itself. If you have heart failure and stopped a beta-blocker due to symptoms, this study may help understand your experience and potentially find better ways to manage it.
LondonAges 18 years+ - NCT07259512RecruitingPhase 4
Ramipril once or twice a day for kidney and heart health
This trial tests whether taking ramipril once or twice daily better protects kidney function in people with both chronic kidney disease (stages 3-5, not on dialysis) and heart failure with low pumping strength. It aims to find the best dosing schedule to help both organs.
Kartasura, Central JavaAges 18 years+ - NCT02537769Recruiting
Surgery to fix a leaky tricuspid valve in LVAD patients
This study looks at whether fixing a mildly leaky tricuspid valve during LVAD surgery improves outcomes for people with advanced heart failure. It’s mainly aimed at patients who are already scheduled to receive an implantable LVAD.
Seattle, WashingtonAges 18 years+ - NCT03215849Enrolling by invitation
Tested pacing device for heart failure with preserved pumping
This trial studies a heart pacing approach in people with heart failure symptoms despite preserved heart pumping. It aims to see whether changing heart timing can improve how you feel and how your heart works during exercise.
CardiffAges Any age - NCT07439159Recruiting
Heart ultrasound to predict outcomes in hospitalized heart failure
This study uses a heart ultrasound (echocardiogram) to predict outcomes in people hospitalized for sudden heart failure. If you are receiving IV fluid-removing medication, the results may help your doctors understand your condition better.
IstanbulAges 18 years+ - NCT07563153Recruiting
Pacemaker Pacing Strategies for Heart Failure Patients
This study tests whether optimized pacemaker settings can improve heart function and symptoms in heart failure patients who need a pacemaker for a slow heartbeat. The goal is to find the best way to program the pacemaker to help your heart work better.
Seoul, SeoulAges 19 years+ - NCT07372651Enrolling by invitation
AI screening for heart failure in pacemaker patients
This trial uses artificial intelligence to screen pacemaker patients for early signs of heart failure. It is designed for people who have a standard pacemaker, do not already have heart failure, and have a high amount of right ventricular pacing.
LeedsAges 18 years+ - NCT07064525Enrolling by invitationPhase 2
Testing a new drug for high blood pressure
This trial tests a new medicine called SPC1001 Low to see if it can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). If you are between 19 and 75 years old and have mild to moderate high blood pressure, this study might be an option.
SeoulAges 19–75 - NCT06935370RecruitingPhase 3
Testing vicadrostat with empagliflozin for heart failure with weak pump
This trial tests a new drug called vicadrostat combined with another drug, empagliflozin, for people with heart failure and a weak heart pump. It aims to see if this combination helps improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 984 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.